Circ-DLG 1 promotes the proliferation of esophageal squamous cell carcinoma [Erratum]

Circular RNAs (circRNAs) are a class of long non-coding RNAs (lncRNAs) which have a circular and closed loop structure. They are ubiquitous, stable, conserved and diverse RNA molecules with a range of activities such as translation and splicing regulation, which are able to interacting with RNA-binding proteins and specially miRNA sponge. The expression patterns of the circRNAs exhibited tissue specificity and also, step and stage specificity. Accumulating evidences approved the critical role of circular RNAs in many cancers such as ovarian cancer. Given that these molecules exert their effects through multiple cellular and molecular mechanisms (i.e., angiogenesis, apoptosis, growth, and metastasis) which are involved in cancer pathogenesis, circular RNAs, in particular, act by controlling cell proliferation in ovarian cancer, so that, it has been shown that the deregulation of these molecules is associated with initiation and progression of ovarian cancer. Therefore, they are attractive molecules which have introduced them as cancer biomarkers. Moreover, they could be used as new therapeutic candidates for developing novel treatment strategies. Here, for first time, we have provided a comprehensive review on the recent knowledge of circular RNAs and their pathological roles in the ovarian cancer.

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Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Shabaninejad

et al. 2019

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Circular RNA is a popular molecule in tumors of the digestive system (Review)

Wang

Zeng

et al. 2020

Int J Oncol

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Most tumors of the digestive system, including esophageal, gastric, liver and colorectal cancer, are malignant tumors that are associated with rates of high morbidity and mortality. The lack of effective methods for early diagnosis is an important cause of poor prognosis for these malignancies. Circular RNAs (circRNAs) belong to a family of endogenous, covalently closed non-coding RNAs that are characterized as having no 5' cap structures or 3' poly-A tails. Shortly following discovery, circRNAs were considered to be a product of mis-splicing and have no significant biological function. However, in recent years, accumulating evidence is demonstrating that they serve key roles in tumorigenesis and have the potential to serve as diagnostic markers. The present article summarizes the biogenesis and function of circRNAs and reviews their role in seven common types of tumor of the digestive system whilst exploring their potential as tumor markers and the significant roles they can serve in the digestive system, in addition to providing a referencing point for future studies of digestive system malignancies.

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Circ-DLG 1 promotes the proliferation of esophageal squamous cell carcinoma [Erratum]

Cited by 2 publications

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Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Circular RNA is a popular molecule in tumors of the digestive system (Review)

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