Circadian and age-related modulation of thermoreception and temperature regulation: mechanisms and functional implications

Someren, Eus J.W. Van; Raymann, Roy; Scherder, E.J.A.; Daanen, H.A.M.; Swaab, Dick F.

doi:10.1016/s1568-1637(02)00030-2

Cited by 173 publications

(118 citation statements)

References 379 publications

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“…La fragmentation de ces rythmes s'explique en partie par une augmentation des épisodes de sommeil pendant la journée et de fréquents réveils pendant la nuit [1,10]. À ces phénomènes, s'ajoutent des modifications dans les modalités de resynchronisation lors d'avances ou de retards de phase [11].…”

Section: Vieillissement Et Rythme D'activité Généraleunclassified

“…Avec l'âge, les profils de température interne chez l'homme, par nature en relation avec le rythme veille/sommeil, présentent une diminution de l'amplitude et s'accompagnent souvent d'une avance de phase du minimum matinal [10]. Chez le microcèbe, les perturbations du rythme et la baisse d'amplitude sont particulièrement marquées en raison de la modification de la phase de torpeur diurne présente chez cette espèce ( Figure 3).…”

Section: Vieillissement Température Interne Et Métabolismeunclassified

“…En outre, les différences saisonnières dans l'expression de la torpeur diurne, normalement observées chez les animaux adultes, disparaissent chez les animaux âgés. L'affaiblissement des rythmes de température interne est à mettre en parallèle avec les déficiences observées à différents niveaux du système de thermorégulation, associant baisse de thermogenèse et augmentation des pertes énergétiques au cours du vieillissement [10,14]. Si chez les primates, les apports caloriques, la composition corporelle et les mécanismes qui les régulent évoluent avec l'âge, peu d'approches rythmiques y ont été consacrées.…”

Section: Vieillissement Température Interne Et Métabolismeunclassified

“…Diverses procédures ont été suggérées pour rétablir l'amplitude du rythme de température interne et supprimer l'avance de phase, avec des effets bénéfiques sur le sommeil. Parmi elles, l'exercice physique ou un bain chaud le soir permettent une augmentation de la dissipation de chaleur et favorisent ainsi la chute de température interne nécessaire à l'endormissement chez l'homme [10]. De même, l'exposition à une lumière forte ou une prise de mélatonine le soir permet de restaurer des profils de température interne.…”

Section: Conclusion Et Perspectivesunclassified

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Vieillissement et rythmes biologiques chez les primates

Perret

Aujard

2006

Med Sci (Paris)

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Section: Vieillissement Et Rythme D'activité Généraleunclassified

Section: Vieillissement Température Interne Et Métabolismeunclassified

Section: Conclusion Et Perspectivesunclassified

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Vieillissement et rythmes biologiques chez les primates

Perret

Aujard

2006

Med Sci (Paris)

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“…This regulation is achieved by the integration of neuronal processes to sense temperature change, hormonal processes to signal multiple organs, metabolic processes in muscle, fat, and liver to adjust heat production, and glandular, pulmonary, and vascular processes to adjust heat loss (Aniansson et al 1986;Lauria et al 1999;Van Someren et al 2002;Passlick-Deetjen and Bedenbender-Stoll 2005). This intricate system is undoubtedly responsible for the great success of mammalian adaptability to various climates; however, such integration and complexity makes it challenging to identify the root cause of impaired thermoregulation.…”

Section: Introductionmentioning

confidence: 99%

Thermoregulation in mice exhibits genetic variability early in senescence

Gonzales

Rikke

2009

AGE

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Aging leads to a loss of thermoregulation that can be readily monitored in laboratory mice. However, it is unclear from previous studies-we provide a tabular summary of 15 articles-whether significant loss occurs by midlife (∼15 months of age). In this study, we examined 34 females from 22 LSXSS strains starting at 4 and 8 months of age (17 mice per age group). We used transponders inserted just under the loose skin of the pelt and calibrated against rectal body temperature to measure temperatures quickly without restraint. We found that the mean body temperatures measured 5 months later (9 and 13 months of age) had dropped significantly below normal in both groups: 0.6ºC lower in the younger cohort and 1.0ºC lower in the older cohort. These drops were not associated with weight loss or signs of pathology. Notably, the loss of thermoregulation between 8 and 13 months of age also exhibited genetic variation that was highly significant (P=0.004). Such variation is potentially a powerful tool for determining the cause of thermoregulatory loss with age and whether this loss predicts senescence changes later in life, including the force of mortality.

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Heat Exposure and Dementia-Related Mortality in China

Gao,

Lin,

Yin

et al. 2024

JAMA Netw Open

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ImportanceAlthough existing research has found daily heat to be associated with dementia-related outcomes, there is still a gap in understanding the differing associations of nighttime and daytime heat with dementia-related deaths.ObjectivesTo quantitatively assess the risk and burden of dementia-related deaths associated with short-term nighttime and daytime heat exposure and identify potential effect modifications.Design, Setting, and ParticipantsThis case-crossover study analyzed individual death records for dementia across all mainland China counties from January 1, 2013, to December 31, 2019, using a time-stratified case-crossover approach. Statistical analysis was conducted from January 1, 2013, to December 31, 2019.ExposuresTwo novel heat metrics: hot night excess (HNE) and hot day excess (HDE), representing nighttime and daytime heat intensity, respectively.Main Outcomes and MeasuresMain outcomes were the relative risk and burden of dementia-related deaths associated with HNE and HDE under different definitions. Analysis was conducted with conditional logistic regression integrated with the distributed lag nonlinear model.ResultsThe study involved 132 573 dementia-related deaths (mean [SD] age, 82.5 [22.5] years; 73 086 women [55.1%]). For a 95% threshold, the median hot night threshold was 24.5 °C (IQR, 20.1 °C-26.2 °C) with an HNE of 3.7 °C (IQR, 3.1 °C-4.3 °C), and the median hot day threshold was 33.3 °C (IQR, 29.9 °C-34.7 °C) with an HDE of 0.6 °C (IQR, 0.5 °C-0.8 °C). Both nighttime and daytime heat were associated with increased risk of dementia-related deaths. Hot nights’ associations with risk of dementia-related deaths persisted for 6 days, while hot days’ associations with risk of dementia-related deaths extended over 10 days. Extreme HDE had a higher relative risk of dementia-related deaths, with a greater burden associated with extreme HNE at more stringent thresholds. At a 97.5% threshold, the odds ratio for dementia-related deaths was 1.38 (95% CI, 1.22-1.55) for extreme HNE and 1.46 (95% CI, 1.27-1.68) for extreme HDE, with an attributable fraction of 1.45% (95% empirical confidence interval [95% eCI], 1.43%-1.47%) for extreme HNE and 1.10% (95% eCI, 1.08%-1.11%) for extreme HDE. Subgroup analyses suggested heightened susceptibility among females, individuals older than 75 years of age, and those with lower educational levels. Regional disparities were observed, with individuals in the south exhibiting greater sensitivity to nighttime heat and those in the north to daytime heat.Conclusions and RelevanceResults of this nationwide case-crossover study suggest that both nighttime and daytime heat are associated with increased risk of dementia-related deaths, with a greater burden associated with nighttime heat. These findings underscore the necessity of time-specific interventions to mitigate extreme heat risk.

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Circadian and age-related modulation of thermoreception and temperature regulation: mechanisms and functional implications

Cited by 173 publications

References 379 publications

Vieillissement et rythmes biologiques chez les primates

Vieillissement et rythmes biologiques chez les primates

Thermoregulation in mice exhibits genetic variability early in senescence

Heat Exposure and Dementia-Related Mortality in China

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