Circadian Rhythm of Serum Cortisol in Female Patients with Fibromyalgia Syndrome

Fatima, Ghizal; Das, Siddharth Kumar; Mahdi, Abbas Ali; Verma, Nar Singh; Khan, Faizan Haider; Tiwari, Arunesh Kumar; Jafer, Tabrez; Anjum, B

doi:10.1007/s12291-012-0258-z

Cited by 15 publications

(16 citation statements)

References 15 publications

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“…It should be pointed out that depending on when CRH is released and where in the brain, it may not necessarily activate the hypothalamic-pituitary-adrenal axis and lead to increased serum cortisol. This may be the reason why morning serum cortisol is not different between FMS patients and controls, but evening cortisol is actually increased in FMS patients (Fatima et al, 2013).…”

Section: Discussionmentioning

confidence: 94%

Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells

Tsilioni

Russell

Stewart

et al. 2016

Journal of Pharmacology and Experimental Therapeutics

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Fibromyalgia syndrome (FMS) is a chronic, idiopathic condition of widespread musculoskeletal pain affecting more women than men. Even though clinical studies have provided evidence of altered central pain pathways, the lack of definitive pathogenesis or reliable objective markers has hampered development of effective treatments. Here we report that the neuropeptides corticotropin-releasing hormone (CRH), substance P (SP), and SP-structurally-related hemokinin-1 (HK-1) were significantly (P 5 0.026, P , 0.0001, and P 5 0.002, respectively) elevated (0.82 6 0.57 ng/ml, 0.39 6 0.18 ng/ml, and 7.98 6 3.12 ng/ml, respectively) in the serum of patients with FMS compared with healthy controls (0.49 6 0.26 ng/ml, 0.12 6 0.1 ng/ml, and 5.71 6 1.08 ng/ml, respectively). Moreover, SP and HK-1 levels were positively correlated (Pearson r 5 0.45, P 5 0.002) in FMS. The serum concentrations of the inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF) were also significantly (P 5 0.029 and P 5 0.006, respectively) higher (2.97 6 2.35 pg/ml and 0.92 6 0.31 pg/ml, respectively) in the FMS group compared with healthy subjects (1.79 6 0.62 pg/ml and 0.69 6 0.16 pg/ml, respectively). In contrast, serum IL-31 and IL-33 levels were significantly lower (P 5 0.0001 and P 5 0.044, respectively) in the FMS patients (849.5 6 1005 pg/ml and 923.2 6 1284 pg/ml, respectively) in comparison with healthy controls (1281 6 806.4 pg/ml and 3149 6 4073 pg/ml, respectively). FMS serum levels of neurotensin were not different from controls. We had previously shown that CRH and SP stimulate IL-6 and TNF release from mast cells (MCs). Our current results indicate that neuropeptides could stimulate MCs to secrete inflammatory cytokines that contribute importantly to the symptoms of FMS. Treatment directed at preventing the secretion or antagonizing these elevated neuroimmune markers, both centrally and peripherally, may prove to be useful in the management of FMS.

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Section: Discussionmentioning

confidence: 94%

Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells

Tsilioni

Russell

Stewart

et al. 2016

Journal of Pharmacology and Experimental Therapeutics

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“…We collected blood at the same time of day for all participants to avoid the effects of daily variations in the level of NO and cortisol (Fatima et al, 2013;Kanabrocki et al, 2001). After blood collection, we allowed the tubes to stand at room temperature for 30 min until the blood clotted.…”

Section: Blood Collection and Preparation Of Blood Samplesmentioning

confidence: 99%

Nitric Oxide, Inflammation, Lipid Profile, and Cortisol in Normal- and Overweight Women With Fibromyalgia

Rus

Molina

Gassó

et al. 2015

Biological Research For Nursing

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“…Since the sleep pattern is disrupted in women with FMS, it may lead to some changes in the circadian rhythm and disrupt the serum cortisol secretion. The circadian oscillation of the cortisol is abnormal in women with FMS [10][11][12]. A study by Fatima et al [11] found the cortisol level in women with FMS to be significantly higher at night.…”

Section: Discussionmentioning

confidence: 97%

“…Chronic pain and stress-related deviations in hormonal secretion occur in patients with FMS. Hypothalamiccorticotrophin-releasing hormone (CRH) neurons are activated in the central nervous system depending on chronic stress [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

The association of carotid intima-media thickness with body mass index and cortisol level in fibromyalgia syndrome

Koca

Çimen

2019

The European Research Journal

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Objective: Patients with fibromyalgia syndrome (FMS) may have the risk for atherosclerotic disease because of chronic stress, disrupted neuroendocrine axis, high BMI and inflammation. This is study aimed to research the stress and the stress-related diseases in patients with FMS by measuring obesity, morning serum cortisol level, and carotid intima-media thickness (CIMT), which is the early indicator of the atherosclerosis. Methods: This is a case-control study. It is included 57 patients who were diagnosed with FMS according to 2010 American College of Rheumatology (ACR) Criteria and visited the outpatient clinic in February 2016. As a control group, 36 healthy females who visited the outpatient clinic in the same month were included. Carotid intima-media thickness and cortisol levels were analysed. Results: The present study included 93 females (between 15 and 79 years old) in total. The mean age of the 57 females with FMS and 37 healthy females was 44.5 ± 10.6 years and 47.9 ± 18.5 years, respectively (p = 0.260). The mean CIMT value of the FMS and control groups was 0.64 ± 0.17 mm and 0.59 ± 0.16 mm, respectively (p = 0.170). The morning blood cortisol level in the FMS and control groups was 7.8 ± 3.3 ng/dL and 8.7 ± 2.8 ng/dL, respectively (p = 0.460). The CIMT and morning blood cortisol level were not correlated in the FMS group. Conclusion: According to the present study, CIMT value and morning blood cortisol level were not found significantly different in FMS group, and also were not found correlated with each other.

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Circadian Rhythm of Serum Cortisol in Female Patients with Fibromyalgia Syndrome

Cited by 15 publications

References 15 publications

Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells

Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells

Nitric Oxide, Inflammation, Lipid Profile, and Cortisol in Normal- and Overweight Women With Fibromyalgia

The association of carotid intima-media thickness with body mass index and cortisol level in fibromyalgia syndrome

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