Circadian rhythms and seizure susceptibility: Relation to 5-hydroxytryptamine and norepinephrine in brain

Schreiber, Robert A.; Schlesinger, Kurt

doi:10.1016/0031-9384(71)90247-2

Cited by 53 publications

(15 citation statements)

References 12 publications

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“…Lowered brain norepinephrine (NE) accompanies the seizure-like activity in the PTX + PX rat (Herrera et al, 1975;. Although no firm conclusions have been made concerning the relation of the lowered catecholamine levels to the occurrence of the PTX + PX convulsions , it has been shown that depressed or lowered NE facilitates convulsive activity afLer the application of epileptogenic stimuli Maynert et al, 1975;Schreiber and Schlesinger, 1971).…”

Section: Introductionmentioning

confidence: 98%

Changes in brain dopamine, norepinephrine and serotonin associated with convulsions induced by pinealectomy in the gerbil

Philo

Reíter

McGill

1979

J. Neural Transmission

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In three separate experiments, adult male gerbils 10 weeks of age were pinealectomized (PX), observed for convulsions, and sacrificed at various intervals after PX. Norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in selected brain parts were determined by fluorometric procedures. No changes in DA were observed. Serotonin levels were shown to be elevated in sham-operated and PX animals, possibly due to stress phenomena associated with anesthesia or surgical procedures. Norepinephrine was significantly depressed over control and sham-operated animals by 1 hour after surgery with a post-operative duration of at least 12 hours. Results in this study did not indicate whether the decreased NE was the cause or an effect of the PX-induced convulsive activity.

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Section: Introductionmentioning

confidence: 98%

Changes in brain dopamine, norepinephrine and serotonin associated with convulsions induced by pinealectomy in the gerbil

Philo

Reíter

McGill

1979

J. Neural Transmission

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“…(3) Direct intercranial injections of 5-HT and NE protect susceptible mice against audiogenic seizures (Schlesinger, Stavnes, and Boggan, 1969). (4) Seizure susceptibility and 5-HT levels in the brain exhibit opposite diurnal cycles (Schreiber and Schlesinger, 1971).…”

Section: Introductionmentioning

confidence: 99%

Catechol‐O‐methyl transferase and monoamine oxidase activities in brains of mice susceptible and resistant to audiogenic seizures

et al. 1975

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The activities of catechol-O-methyl transferase (COMT), monoamine oxidase (MAO), and a methanol forming enzyme were studied in whole brain homogenates and in livers obtained from DBA/2J, C57B1/6J, and F1 hybrid mice. DBA/2J mice are extremely susceptible to audiogenic seizures, whereas C57B1/6J mice are resistant to sound-induced convulsions. C57B1/6J mice were found to have significantly higher brain levels of COMT, while MAO activities were not different in animals of these genotypes. No methanol forming activity was detected in animals of either strain. No differences were found in hepatic activities of either COMT or MAO. Pyrogallol was shown to protect DBA/2J animals against audiogenic seizures.

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“…Then, circadian varia tions of the brain contents of serotonin, norepinephrine and dopamine were studied by several authors (Albrecht et al, 1956;Asano, 1971;Dixit andBuckley, 1967\Graziani andMontanaro, 1966;Hery et al, 1972;Margides et al, 1972;Quay, 1965Quay, , 1967Reis et al, 1968Reis et al, , 1969Scapagnini et al, 1971;Scheving et al, 1968;Schreiber and Schlesinger, 1971;Wirz-Justice, 1974;Wurtman and Axelrod, 1966;Wurtman et al, 1967).…”

Section: Introductionmentioning

confidence: 99%

Annual and Daily Changes in Brain Serotonin Content in Differentially Housed Mice

Valzelli¹,

Bernasconi²,

Cusumano³

1977

Neuropsychobiology

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The annual and daily variations of brain serotonin and 5-hydroxyindolacetic acid have been studied over a 6-year period in normally grouped and isolated mice. The results obtained indicate that differences exist between normally grouped and isolated animals, especially when referred to the annual changes to which brain serotonin and 5-hy-droxyindolacetic acid undergo. The results suggest that the outcome of the experiments on neurochemistry, neuropharmacology and behavior can change according to the month of the year and they can further be modified by differential housing of mice.

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Circadian rhythms and seizure susceptibility: Relation to 5-hydroxytryptamine and norepinephrine in brain

Cited by 53 publications

References 12 publications

Changes in brain dopamine, norepinephrine and serotonin associated with convulsions induced by pinealectomy in the gerbil

Changes in brain dopamine, norepinephrine and serotonin associated with convulsions induced by pinealectomy in the gerbil

Catechol‐O‐methyl transferase and monoamine oxidase activities in brains of mice susceptible and resistant to audiogenic seizures

Annual and Daily Changes in Brain Serotonin Content in Differentially Housed Mice

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