Circadian rhythms of urinary excretion: the relationship between the amount excreted and the circadian changes.

Minors, D.S.; Waterhouse, Jim

doi:10.1113/jphysiol.1982.sp014218

Cited by 36 publications

(17 citation statements)

References 23 publications

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“…The urinary excretion of all major solutes (Na ϩ , K ϩ , Cl Ϫ , urea, PO 4 Ϫ , Ca 2ϩ , Mg 2ϩ ) also follows a circadian oscillating pattern. Although, renal excretion rhythms are apparently synchronized with circadian rhythms of activity/feeding, they have been shown to persist over long periods of time under experimental conditions in which external factors such as dietary intake, posture, or sleep were kept constant or were manipulated in a noncircadian manner (10)(11)(12)(13)(14)(15)(16). These results have indicated that in addition to the external circadian stimuli (hormones, food, food metabolites) these functional rhythms are also controlled by a self-sustained intrinsic renal clock.…”

mentioning

confidence: 99%

Molecular clock is involved in predictive circadian adjustment of renal function

Zuber

Centeno

Pradervand

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

245

237

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Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechanisms underlying circadian rhythms in the distal nephron segments, i.e., distal convoluted tubule (DCT) and connecting tubule (CNT) and the cortical collecting duct (CCD). Temporal expression analysis performed on microdissected mouse DCT/CNT or CCD revealed a marked circadian rhythmicity in the expression of a large number of genes crucially involved in various homeostatic functions of the kidney. This analysis also revealed that both DCT/CNT and CCD possess an intrinsic circadian timing system characterized by robust oscillations in the expression of circadian core clock genes (clock, bma11, npas2, per, cry, nr1d1) and clock-controlled Par bZip transcriptional factors dbp, hlf, and tef. The clock knockout mice or mice devoid of dbp/hlf/tef (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance (vasopressin V2 receptor, aquaporin-2, aquaporin-4, ␣ENaC). Functionally, the loss of clock leads to a complex phenotype characterized by partial diabetes insipidus, dysregulation of sodium excretion rhythms, and a significant decrease in blood pressure. Collectively, this study uncovers a major role of molecular clock in renal function.circadian rhythm ͉ homeostasis ͉ renal function R ecent evidence suggests that many if not all specific physiological functions are under the control of the circadian timing system. The mammalian circadian timing system is a hierarchically organized network of molecular oscillators driven by a central pacemaker located in the suprachiasmatic nucleus (SCN) of hypothalamus. This central pacemaker functions in a self-sustained fashion, but is reset each day by exposure to environmental synchronizers, mainly the light/dark cycle. The SCN masterclock drives the rest-activity cycle, which in turn imposes the feeding pattern [reviewed in (1, 2)]. The feeding time seems to be the dominant cue for circadian rhythms in the peripheral tissues (3, 4). Central and peripheral oscillators share a similar molecular core clock based on a set of self-autonomous transcriptional/ translational feedback loops. The key molecular components of these loops are the PAS domain transcriptional factors CLOCK, BMAL1, and NPAS2 and the feedback repressors PER1, PER2, CRY1, and CRY2. The orphan nuclear receptors NR1D1 and, probably, NR1D2 form an accessory feedback loop. The core oscillators confer circadian rhythmicity on a set of output genes underlying the tissue-specific functional rhythms. Current estimates indicate that up to 10% of the cellular transcriptome may follow a circadian expression pattern (5-7). Several recent studies have also demonstrated that the transcription of only a minority of these circadian genes is driven by systemic humoral or neurona...

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mentioning

confidence: 99%

Molecular clock is involved in predictive circadian adjustment of renal function

Zuber

Centeno

Pradervand

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

245

237

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“…These subdivisions were based upon previous experiments (Simpson et al 1970;Mills et -al. 1977; Minors & Waterhouse, 1982) which indicated that the first group was affected mainly by exogenous influences, the last by endogenous factors and that sodium and chloride were intermediate in these respects.…”

Section: Resultsmentioning

confidence: 99%

“…A further difficulty arises in that the size of the direct effect of sleep might be expected to depend upon the variable under consideration (Minors& Waterhouse, 1982). This is clearly seen when human subjects live on non-24-h 'days' (Simpson, Lobban & Halberg, 1970;Mills, Minors & Waterhouse, 1977).…”

Section: Introductionmentioning

confidence: 99%

Does ‘anchor sleep’ entrain circadian rhythms? Evidence from constant routine studies.

Minors¹,

Waterhouse²

1983

The Journal of Physiology

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SUMMARY1. Experiments have been performed in an isolation unit to investigate the effects of abnormal sleep-waking schedules upon circadian rhythms of renal excretion and deep-body temperature.2. In confirmation of previous work, nychthemeral rhythms appeared to be 'anchored' to a 24 h period if 4 h sleep was taken regularly each day, even though another 4 h was taken irregularly.3. The endogenous components were investigated by assessing circadian rhythmicity under constant routine conditions, that is, when rhythmic influences in the environment and sleep-waking pattern had been minimized.4. Analysis of the constant routine data indicated the presence of a rhythmic component which had been stabilized to a period of 24 h by the 'anchor sleep'. In addition, a delayed component was also present.5. The starting time of the constant routines produced a direct effect upon the rhythms, which was presumed to result from removing the 'masking' effect that sleep normally exerts upon rhythms. There was some evidence that the relative importance of the masking effect and the delayed component depended upon the variable under consideration.6. The implications of these findings, in terms of the effects of anchor sleep, the presence of more than one internal clock and the usefulness of constant routines, are discussed.

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“…Each of the atrial natriuretic peptides (VSDL, LANP, and ANF) exhibits a circadian rhythm in the circulation of healthy diurnally active individuals, with their peak concentrations in the middle of the night [21,22], Promi nent circadian rhythms in urinary excretion rates for Na and Cl have been described and documented to result from both endogenous and exogenous mechanisms [23,24], However, circadian rhythms in serum Na and Cl are not as prominent, having been reported for some groups of healthy subjects, but not in others [25]. The present investigation was undertaken to determine (1) whether serum Na and Cl have a circadian rhythm and (2) whether one or more of these atrial peptides have a temporal (cir cadian) and/or functional (overall) relationship to serum Na and/or Cl.…”

Section: Introductionmentioning

confidence: 99%

Circadian Relationships between Circulating Atrial Natriuretic Peptides and Serum Sodium and Chloride in Healthy Humans

et al. 1996

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Long-acting natriuretic peptide (LANP), vessel dilator (VSDL), and atrial natriuretic factor (ANF) consisting of amino acids 1-30, 31-67, and 99-126 of the 126 amino acid ANF prohormone, respectively, circulate in humans and have potent natriuretic properties. To determine whether these peptides have a direct relationship to serum Na and/or Cl, we examined 21 24-hour profiles of these peptides and Na and Cl in 14 healthy humans. LANP, VSDL, ANF, and Cl had significant (p < 0.001) circadian rhythms with peak concentrations at 04.00 h. The circadian rhythm of serum Na was exactly opposite. Sodium correlated negatively with LANP (p = 0.021) and ANF (p = 0.007), while Cl correlated positively with LANP (p = 0.003) and VSDL (p = 0.001). These data suggest that the atrial peptides may be important for the maintenance of serum Na and Cl within their normal ranges and in the modulation of their daily circadian rhythms.

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Circadian rhythms of urinary excretion: the relationship between the amount excreted and the circadian changes.

Cited by 36 publications

References 23 publications

Molecular clock is involved in predictive circadian adjustment of renal function

Molecular clock is involved in predictive circadian adjustment of renal function

Does ‘anchor sleep’ entrain circadian rhythms? Evidence from constant routine studies.

Circadian Relationships between Circulating Atrial Natriuretic Peptides and Serum Sodium and Chloride in Healthy Humans

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