CircARID1A regulates mouse skeletal muscle regeneration by functioning as a sponge of miR‐6368

Liu, Jia; Li, Menglu; Kong, Linghao; Cao, MengWen; Zhang, MoLan; Wang, Yanhong; Song, Chengchuang; Fang, Xingtang; Chen, Hong; Zhang, Chunlei

doi:10.1096/fj.202001992r

Cited by 17 publications

(12 citation statements)

References 53 publications

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“…Currently, several molecular mechanisms underpinning circRNAs, such as miRNA sponge (ceRNA mechanism) [25,48], carrier for RNA-binding protein [24], and even circRNA-translated peptides [49], have been discovered in the proliferation and differentiation of MuSCs [50,51]. Among these, the ceRNA mechanism, e.g., circRNAs competitively bind miRNAs and consequently release the degradation of miRNA-targeted genes, has been ranked first.…”

Section: Discussionmentioning

confidence: 99%

Suppression of CircTCF4 on the Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells

Zheng¹,

Li²,

Zhou³

et al. 2022

Preprint

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The proliferation and differentiation of mammalian skeletal muscle satellite cells (MuSCs) are highly complicated. Apart from the regulatory signaling cascade driven by the protein-coding genes, non-coding RNAs like microRNAs (miRNA) and circular RNAs (circRNAs) play essential roles in this biological process. However, circRNA functions in MuSCs proliferation and differentiation remain largely to be elucidated. Here, we screened for an exonic circTCF4 based on our previous RNA-Seq data, specifically expressed during the development of the longest dorsal muscle in goats. Subsequently, the circular structure and whole sequence of circTCF4 were verified using Sanger sequencing. Besides, circTCF4 was spatiotemporally expressed in multiple tissues from goats but strikingly enriched in muscles. Furthermore, circTCF4 suppressed MuSCs proliferation and differentiation, independent of AGO2 binding. Finally, we conducted Poly(A) RNA-Seq using cells treated with small interfering RNA targeting circTCF4 and found that circTCF4 would affect multiple signaling pathways, including insulin signaling pathway and AMPK signaling pathway related to muscle differentiation. Our results provide additional solid evidence for circRNA regulating skeletal muscle formation.

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Section: Discussionmentioning

confidence: 99%

Suppression of CircTCF4 on the Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells

Zheng¹,

Li²,

Zhou³

et al. 2022

Preprint

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“…Circ-HIPK3 is involved in promoting C2C12 myoblast proliferation and differentiation through the MiR-7 and transcription factor 12 ( TCF12 ) axis [ 97 ]. Circ-ARID1A promotes skeletal muscle regeneration by targeting MiR-6368 [ 98 ] and affects skeletal muscle strength [ 99 ].…”

Section: Circrna Modulates Skeletal Muscle In Domestic Chickensmentioning

confidence: 99%

Regulation of Non-Coding RNA in the Growth and Development of Skeletal Muscle in Domestic Chickens

Shi

et al. 2022

Genes

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Chicken is the most widely consumed meat product worldwide and is a high-quality source of protein for humans. The skeletal muscle, which accounts for the majority of chicken products and contains the most valuable components, is tightly correlated to meat product yield and quality. In domestic chickens, skeletal muscle growth is regulated by a complex network of molecules that includes some non-coding RNAs (ncRNAs). As a regulator of muscle growth and development, ncRNAs play a significant function in the development of skeletal muscle in domestic chickens. Recent advances in sequencing technology have contributed to the identification and characterization of more ncRNAs (mainly microRNAs (miRNAs), long non-coding RNAs (LncRNAs), and circular RNAs (CircRNAs)) involved in the development of domestic chicken skeletal muscle, where they are widely involved in proliferation, differentiation, fusion, and apoptosis of myoblasts and satellite cells, and the specification of muscle fiber type. In this review, we summarize the ncRNAs involved in the skeletal muscle growth and development of domestic chickens and discuss the potential limitations and challenges. It will provide a theoretical foundation for future comprehensive studies on ncRNA participation in the regulation of skeletal muscle growth and development in domestic chickens.

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“…In addition, the up-regulation of oncogenic miRNAs causes the down-regulation of tumor suppressor gene expression. On the contrary, the down-regulation of oncogenic miRNAs causes the expression level of oncogenes to increase [ 10 ]. Pandolfi et al put forward the hypothesis of competitive endogenous RNA: noncoding RNA, pseudogenes, and mRNA can compete with miRNA to mutually regulate their genes, providing a new mechanism for gene regulation [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

CircINTS4 Facilitates Chemoresistance of TNBC by Competitively Binding miR-129-5p/POM121 Axis

Tang

Zhou

Yang

et al. 2022

Journal of Oncology

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Objectives. To detect the expression of circular RNA (circRNA) circINTS4 in triple-negative breast cancer (TNBC) and to analyze the relationship between the expression of circRNA circINTS4 and the clinicopathological characteristics and chemotherapy resistance of patients with TNBC. Methods. Bioinformatics was used to predict that circINTS4 and POM121 could bind to miR-129-5p, and dual luciferase reporter genes proved that circINTS4 could bind to miR-129-5p and miR-129-5p could bind to POM121. RNA immunoprecipitation (RIP) and RNA pull-down experiments confirmed that circINTS4 binds to miR-129-5p. The correlation among circINTS4, miR-129-5p, and POM121 was detected by qRT-PCR. Results. In ADR-resistant TNB cells, circINTS4 was significantly up-regulated, miR-129-5p was down-regulated, and POM121 protein expression was significantly up-regulated. Experimental results showed that circINTS4 knockdown inhibited proliferation, migration, invasion, and autophagy. Knocking down miR-129-5p or overexpression of POM121 reversed the inhibitory effect of sh-circints4 on the development of ADR-resistant TNBC cells. In addition, CIRCINTS4 regulates POM121 expression by sponge-adsorbed miR-129-5p. CIRCINTS4 knockdown prevents ADR-resistant tumor growth by regulating the miR-129-5p/POM121 axis in vivo. Conclusions. CircRNA circINTS4 may act as the ceRNA of miR-129-5p to regulate the expression of target gene POM121, thereby promoting the progress of TNBC molecular mechanism and providing scientific basis for circINTS4 as a new molecular target for clinical diagnosis and drug resistance therapy of TNBC.

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CircARID1A regulates mouse skeletal muscle regeneration by functioning as a sponge of miR‐6368

Cited by 17 publications

References 53 publications

Suppression of CircTCF4 on the Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells

Suppression of CircTCF4 on the Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells

Regulation of Non-Coding RNA in the Growth and Development of Skeletal Muscle in Domestic Chickens

CircINTS4 Facilitates Chemoresistance of TNBC by Competitively Binding miR-129-5p/POM121 Axis

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