CircNCX1: the “Lord of the Ring” in the Heart — Insight into Its Sequence Characteristic, Expression, Molecular Mechanisms, and Clinical Application

Ding, Lin; Li, Mengyang; Yang, Fuqing; Jx, Wang

doi:10.1007/s12265-021-10176-y

Cited by 3 publications

(2 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one such study, Cdr1as overexpression was shown to promote mouse cardiac myocyte apoptosis and to exacerbate cardiac infarct size by targeting miR-7a [ 80 ]. circNCX1 suppression in mice’ hearts can reduce cardiac ischemia–reperfusion-induced cardiac injury by sponging miR-133a-3p, which would otherwise promote cardiomyocyte apoptosis [ 81 , 82 ]. In the rat myocardium, circ-TTC3, one of the abundantly expressed circRNAs, is significantly upregulated 5 weeks following MI [ 83 ].…”

Section: The Role Of Circrnas In Cvdsmentioning

confidence: 99%

Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Wang

Spanos

et al. 2023

Research

View full text Add to dashboard Cite

Cardiovascular disease is one of the leading causes of mortality worldwide. Recent studies have shown that circular RNAs (circRNAs) have emerged as important players in the prevention and treatment of cardiovascular diseases. circRNAs are a class of endogenous noncoding RNAs that are generated by back-splicing and are involved in many pathophysiological processes. In this review, we outline the current research progress on the regulatory roles of circRNAs in cardiovascular diseases. Further, new technologies and methods available for identifying, validating, synthesizing, and analyzing circRNAs, as well as their applications in therapeutics, are highlighted here. Moreover, we summarize the increasing insights into the potential use of circRNAs as circulating diagnostic and prognostic biomarkers. Finally, we discuss the prospects and challenges of circRNA therapeutic applications for cardiovascular disease therapy, with a particular focus on developing circRNA synthesis and engineering delivery systems.

show abstract

Section: The Role Of Circrnas In Cvdsmentioning

confidence: 99%

Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Wang

Spanos

et al. 2023

Research

View full text Add to dashboard Cite

show abstract

“…CircRNAs were found to serve a critical role in embryonic development, and the dysfunctions of circRNAs were associated with different developmental disorders. 10,11 For example, circRNAs involved in the development of many diseases, such as embryonic heart, 12 neurological disorders 13,14 and male infertility. 15,16 However, the roles of circRNAs in cleft palates by TCDD induce were still unknown.…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of differentially expressed circRNA in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cleft palate

et al. 2023

View full text Add to dashboard Cite

Various circular RNAs (circRNAs) are novel class of non-coding RNAs, which are pervasively transcribed in the genome. CircRNAs play important roles in human, animals and plants. Up to now, there was no report regarding circRNAs of cleft palate by 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) induce. The present study screened identification and characterization of differential expressed-circRNAs in TCDD-induced cleft palate. 6903 circRNAs candidates came from cleft palates. Among them, 3525 circRNAs are up-regulation, and 3378 circRNAs are down-regulation by TCDD induce. The cluster and GO analysis found that circRNAs involved in biological process, cellular component, and molecular function. Through the analysis of KEGG Pathway, circRNAs made functions via classical signaling pathway in cleft palate, such as TGF-beta signaling pathway, BMP signal pathway, MAPK signaling pathway. In addition, we found down-regulated circRNA224, circRNA3302 and up-regulated circRNA5021 targeted tgfbr3, but up-regulated circRNA4451 targeted tgfbr2. circRNA4451 may make functions through TGF-beta signaling pathway. These results suggested that many different circRNAs may make important role in TCDD-induced cleft palate, which provided a theoretical basis for further research.

show abstract

Research progress of circular RNAs in myocardial ischemia

Tibenda,

Wang,

et al. 2024

Life Sciences

View full text Add to dashboard Cite

CircNCX1: the “Lord of the Ring” in the Heart — Insight into Its Sequence Characteristic, Expression, Molecular Mechanisms, and Clinical Application

Cited by 3 publications

References 109 publications

Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Identification and characterization of differentially expressed circRNA in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cleft palate

Research progress of circular RNAs in myocardial ischemia

Contact Info

Product

Resources

About