Circular RNAs in early brain development and their influence and clinical significance in neuropsychiatric disorders

Zhuo, Chuanjun; Hou, Weihong; Jiang, Deguo; Tian, Hongjun; Wang, Lina; Feng, Jia; Zhou, Chunhua; Zhu, Jingjing

doi:10.4103/1673-5374.268969

Cited by 37 publications

(33 citation statements)

References 58 publications

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“…According to bioinformatics resources, rs237911 resides the region of intronic circular RNA (circRNA), which represents a class of small non-coding RNAs functioning as microRNA sponges, regulators of splicing and transcription, modifiers of parental gene expression, and interacting with RNA binding proteins ( Qu et al., 2017 ). Moreover, due to circRNAs high expression in the brain, their role in early brain development and other brain-related processes ( Zhuo et al., 2020 ) including depression-like behavior ( Zhang et al., 2018 ) have been recently reported. In addition, birth order might have an indirect effect on depressive-like behavior via changes in intrauterine environment caused by previous delivery, which plays a key role in shaping offspring DNA methylation of genes related to “Nervous system development and function” pathway ( Li et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level

Казанцева

Davydova

Enikeeva

et al. 2020

Heliyon

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Background Multiple studies of depression indicated a significant role of gene-by-environment interactions; however, they are mainly limited to the examination of modulating effect of recent stressful life events. Other environmental factors occurring at different stages of ante- and postnatal development may affect the association between multiple genes and depression. The study aimed to analyze the main and haplotype-based effect of serotonergic system and HPA-axis gene polymorphisms on depression and to detect gene-by-environment interaction models explaining individual variance in depression in mentally healthy young adults from Russia. Methods Depression score was assessed using Beck Depression Inventory (BDI) in 623 healthy individuals (81% women; 17-25 years) of Caucasian origin (Russians, Tatars, Udmurts) from Russia. The main- and gene-based effects of 12 SNPs in SLC6A4 (5-HTTLPR, rs1042173), HTR2A (rs7322347), OXTR (rs7632287, rs2254298, rs13316193, rs53576, rs2228485, rs237911), AVPR1A (rs3803107, rs1042615), and AVPR1B (rs33911258) genes, and gene-by-environment interactions were tested with linear regression models (PLINK v.1.9) adjusted for multiple comparisons. Results We observed ethnicity-specific main effect of the AVPR1A rs3803107 (P = 0.003; P FDR = 0.047) and gene-based effect of the OXTR gene (Р = 0.005; P perm = 0.034) on BDI-measured depression, and modifying effect of paternal care on OXTR rs53576 (P = 0.004; P FDR = 0.012) and birth order on OXTR rs237911 (P = 0.006; P FDR = 0.018) association with depression level. Limitations A hypothesis driven candidate gene approach, which examined a limited number of genetic variants in a moderately large sample, was used. Conclusions Our preliminary findings indicate that familial environment may play a permissive role modulating the manifestation of OXTR -based depression variance in mentally healthy subjects.

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Section: Discussionmentioning

confidence: 99%

AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level

Казанцева

Davydova

Enikeeva

et al. 2020

Heliyon

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“…35 Similarly, exosomes present in biofluids can express certain diagnostic and therapeutic properties. For example, in-depth study of circRNAs in exosomes present in blood or cerebrospinal fluid can contribute to reveal the underlying mechanisms of the development of neuropsychiatric disorders 36 . Furthermore, miRNAs carried by serum exosomes can be used for the diagnosis and prognosis of spinal cord injury (SCI) 37 .…”

Section: Classificationmentioning

confidence: 99%

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

Zhang¹,

Bi²,

Huang³

et al. 2020

IJN

809

624

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Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic acids, proteins, lipids and other bioactive substances to play a role in the body's physiological and pathological processes. Compared to synthetic carriers such as liposomes and nanoparticles, the endogeneity and heterogeneity of exosomes give them extensive and unique advantages in the field of disease diagnosis and treatment. However, the storage stability, low yield, low purity, and weak targeting of exosomes limit its clinical application. For this reason, further exploration is needed to optimize the above problems and facilitate future functional studies of exosomes. In this paper, the origin, classification, preparation and characterization, storage stability and applications of exosome delivery system are summarized and discussed by searching a large number of literatures.

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“…Lukiw et al [26] showed that circRNA-7 might act as a miR-7 sponge to serve as Alzheimer's disease promoter via regulating expression of ubiquitinconjugating enzyme E2A(UBE2A) and the epidermal growth factor receptor (EGFR). Additionally, a group of circRNAs has also been identi ed to be crucial for neuropsychiatric disorders [27]. Mahmoudi and colleagues brie y investigated the capacity of circRNA for modulating miRNA function in schizophrenia disease [18].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Identification of Non-coding RNA Biomarkers in Stress-induced Depression via Comprehensive Analysis of Competing Endogenous RNA Network

liu¹,

Liu²,

Lin

et al. 2020

Preprint

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BackgroundDepression is one of the most common psychiatric disease worldwide. Although the research about the pathogenesis of depression have achieved progress, the detailed effect of non-coding RNAs (ncRNAs) in depression are still not clearly elucidated. This study was aimed to identify non-coding RNA biomarkers in stress-induced depression via comprehensive analysis of competing endogenous RNA networkMethodsIn this present study, we acquired RNA expression from RNA seq expression profile in three mice with depressive-like behaviors using chronic restraint stress paradigm and three C57BL/6J wild-type mice as control mice. ResultsA total of 41 differentially expressed circular RNAs (circRNAs) and 181 differentially expressed messenger RNAs (mRNAs) were up-regulated, and 65 differentially expressed circRNAs and 289 differentially expressed mRNAs were down-regulated, which were selected by a threshold of fold change ≥2 and a p-value < 0.05. Gene Ontology was performed to analyze the biological functions, and we predicted potential signaling pathways based on Kyoto Encyclopedia of Genes and Genomes pathway database. In addition, we constructed a circRNA-microRNA (miRNA)-mRNA regulatory network to further identify non-coding RNAs biomarkers. ConclusionsOur findings provide a promising perspective for further research into molecular mechanisms of depression, and targeting circRNA -mediated competing endogenous RNA (ceRNA) network is a useful strategy to early recognize the depression.

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Circular RNAs in early brain development and their influence and clinical significance in neuropsychiatric disorders

Cited by 37 publications

References 58 publications

AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level

AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

WITHDRAWN: Identification of Non-coding RNA Biomarkers in Stress-induced Depression via Comprehensive Analysis of Competing Endogenous RNA Network

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Circular RNAs in early brain development and their influence and clinical significance in neuropsychiatric disorders

Cited by 37 publications

References 58 publications

AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level

AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

WITHDRAWN: Identification of Non-coding RNA&nbsp;Biomarkers in Stress-induced Depression via Comprehensive Analysis of Competing Endogenous RNA&nbsp;Network

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WITHDRAWN: Identification of Non-coding RNA Biomarkers in Stress-induced Depression via Comprehensive Analysis of Competing Endogenous RNA Network