Circulating angiogenic factors during periovulation and the luteal phase of normal menstrual cycles

Malamitsi‐Puchner, Ariadne; Sarandakou, Angeliki; Tziotis, John; Stavréus-Evers, Anneli; Τζώνου, Αναστασία; Landgren, Britt-Marie

doi:10.1016/j.fertnstert.2003.10.025

Cited by 31 publications

(29 citation statements)

References 23 publications

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“…Unlike previous study (2,24), the changes in VEGF in this study did not achieve significance at the times studied over the menstrual cycle; however, SCF showed variability (p=0.041) with the lowest values in weeks 2 and 3 (figure 1). The fact that VEGF did not reach statistical significance for variation during the menstrual cycle in this study may be secondary to the timing and definition of the weeks of the cycle.…”

Section: Circulating Epc Over the Menstrual Cyclecontrasting

confidence: 96%

“…Angiogenesis is routine during the reproductive cycle, with vessels forming and regressing in the endometrium and ovaries during the menstrual cycle under the control of hormones and angiogenic factors, such as vascular endothelial growth factor (VEGF) (2,24,29). VEGF levels vary over the menstrual cycle with two peaks, around ovulation and during the luteal phase (2,24).…”

Section: Introductionmentioning

confidence: 99%

“…VEGF levels vary over the menstrual cycle with two peaks, around ovulation and during the luteal phase (2,24). Although tissue resident endothelial cells participate in the new vessel formation, bone marrow-derived endothelial progenitor cells (EPC) also actively promote the formation of new blood vessels and the maintenance of vascular homeostasis (16,17,28).…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle

Farha¹,

Asosingh²,

Laskowski³

et al. 2007

Journal of Applied Physiology

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Gas transfer in the female lung varies over the menstrual cycle in parallel with the cyclic angiogenesis that occurs in the uterine endometrium. Given that vessels form and regress in the uterus under the control of hormones, angiogenic factors and pro-angiogenic circulating bone marrow-derived progenitor cells, we tested the possibility that variation in pulmonary gas transfer over the menstrual cycle is related to a systemic cyclic pro-angiogenic state that influences lung vascularity. Women were evaluated over the menstrual cycle with weekly measures of lung diffusing capacity and its components, the pulmonary vascular capillary bed and membrane diffusing capacity, and their relation to circulating CD34 + CD133 + progenitor cells, hemoglobin, factors affecting hemoglobin binding affinity, and pro-angiogenic factors. Lung diffusing capacity varied over the menstrual cycle, reaching a nadir during the follicular phase following menses. The decline in lung diffusing capacity was accounted for by ~25% decrease in pulmonary capillary blood volume. In parallel, circulating CD34 + CD133 + progenitor cells decreased bỹ 24%, and were directly related to angiogenic factors, and to lung diffusing capacity and pulmonary capillary blood volume. The finding of greater number of lung microvessels in ovariectomized female mice receiving estrogen as compared to placebo verified that pulmonary vascularity is influenced by hormonal changes. These findings suggest that angiogenesis in the lungs may participate in the cyclic changes in gas transfer that occur over the menstrual cycle.

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Section: Circulating Epc Over the Menstrual Cyclecontrasting

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle

Farha¹,

Asosingh²,

Laskowski³

et al. 2007

Journal of Applied Physiology

View full text Add to dashboard Cite

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“…VEGF is not affected by age and gender (140). During the menstrual cycle VEGF peaks between days −1 and 1 and on day 9, suggesting a role in the preparation of the endometrium to reproduction (152). Hetland and colleagues showed that VEGF has a peak at 7 a.m. and two nadirs at 1 and 4 p.m. with no differences among healthy subjects and RA patients.…”

Section: Pre-analytical Factorsmentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

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Abstract:In the last few years, a growing number of molecules have been associated to an endocrine function of the skeletal muscle. Circulating myokine levels, in turn, have been associated with several pathophysiological conditions including the cardiovascular ones. However, data from different studies are often not completely comparable or even discordant. This would be due, at least in part, to the whole set of situations related to the preparation of the patient prior to blood sampling, blood sampling procedure, processing and/or store. This entire process constitutes the pre-analytical phase. The importance of the preanalytical phase is often not considered. However, in routine diagnostics, the 70% of the errors are in this phase. Moreover, errors during the pre-analytical phase are carried over in the analytical phase and affects the final output. In research, for example, when samples are collected over a long time and by different laboratories, a standardized procedure for sample collecting and the correct procedure for sample storage are acknowledged. In this review, we discuss the pre-analytical variables potentially affecting the measurement of myokines with cardiovascular functions.

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“…Uterine angiogenesis in mice is severely compromised when VEGF, but not angiopoietin, signaling is defective, and this defect is rescued by exogenously supplying a stable prostacyclin agonist (49). In women, circulating levels of VEGF peak approximately 9 days after the luteinizing hormone surge, around the time of implantation ( Figure 1) (50). However, it is not clear whether the fluctuation in VEGF levels is directly regulated by PGs, as in mice, or by steroid hormones.…”

Section: Figurementioning

confidence: 99%

Uterine disorders and pregnancy complications: insights from mouse models

Lim¹,

Wang²

2010

J. Clin. Invest.

114

104

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Much of our knowledge of human uterine physiology and pathology has been extrapolated from the study of diverse animal models, as there is no ideal system for studying human uterine biology in vitro. Although it remains debatable whether mouse models are the most suitable system for investigating human uterine function(s), gene-manipulated mice are considered by many the most useful tool for mechanistic analysis, and numerous studies have identified many similarities in female reproduction between the two species. This Review brings together information from studies using animal models, in particular mouse models, that shed light on normal and pathologic aspects of uterine biology and pregnancy complications.The uterus: a privileged place for new life Early in the history of medicine, the uterus was considered a root of women's mental health. Hippocrates conceived the term "hysteria" (from the Greek word for uterus, hystera) to explain a femalespecific mental condition originating from perturbation of the uterus (1). We now know that the uterus does not contribute to such psychologic problems, but it remains a compound source of many female-specific pathologic conditions.The uterus is part of the urogenital system, which begins to develop in the embryo soon after gastrulation (a process fundamental for formation of the three embryonic layers). It arises from structures known as the Müllerian ducts (MDs) - a pair of ducts that run down the lateral sides of the embryonic urogenital ridge and form the oviducts, uterus, cervix, and upper portion of the vagina - in a process that requires an intricate interplay of many genes (2). To perform its ultimate reproductive function, the uterus is equipped to undergo a finite number of cycles under the regulation of ovarian sex steroid hormones. During these recurring cycles, the endometrial cells lining the uterine cavity proliferate and then regress but are never depleted and do not proliferate out of the normal range (Figure 1) (3). If this tight regulation is somehow perturbed, conditions in the uterus adversely influence fertility, providing some of the many obstacles that reduce the rate of successful human term pregnancy to only 30% of eggs that contact sperm (4). Chromosomal aberrations are the main reason underlying the low rate of successful human term pregnancies, but other major pregnancy complications that reduce the rate of successful human term pregnancy include ectopic pregnancy, preterm birth, intrauterine growth retardation (IUGR), and preeclampsia (5-7).Ethical issues are a fundamental restriction to the study of human pregnancy, as it is virtually impossible to obtain proper human samples for cellular and molecular studies. Indeed, observations using medical devices and a small number and size of endometrial biopsies have been the primary sources from which information on the pathophysiology of the human endometrium has been gathered. Another restriction to studying human uterine biology is that there is no ideal cell culture system that truly suffices fo...

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Circulating angiogenic factors during periovulation and the luteal phase of normal menstrual cycles

Cited by 31 publications

References 23 publications

Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle

Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Uterine disorders and pregnancy complications: insights from mouse models

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