Circulating Antibody Response in Malignant Disease

Lytton, Bernard; Hughes, L. E.; Fulthorpe, A. J.

doi:10.1016/s0140-6736(64)91390-x

Cited by 45 publications

(13 citation statements)

References 8 publications

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“…Allergic patients represent the end of a spectrum of immunological activity characterised by the ability to form reagin-type antibodies. Serafini, Torrigani and Masala (1965) Lytton, 1964). It is possible that a cancer specific antigen may be of the same molecular pattern as organ specific antigens and the allergic patients may give an immune response to cancer tissue.…”

Section: Methods and Resultsmentioning

confidence: 99%

“…It is therefore important to investigate the immunological reactivity of patients with cancer. Patients with established cancer have a depressed immune system whether measured by humoral antibody formation (Lytton, Hughes and Fulthorpe, 1964), delayed hypersensitivity reactions (Hughes and Mackay, 1965), or homograft rejection rates (Southam and Pillemer, 1957), but little is known of the immunological activity in the patient before the development of the tumour. In an attempt to investigate this indirectly, the incidence of allergic conditions in cancer patients and in control subjects has been studied.…”

mentioning

confidence: 99%

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The incidence of allergic disorders and cancer.

Mackay¹

1966

Br J Cancer

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Section: Methods and Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

The incidence of allergic disorders and cancer.

Mackay¹

1966

Br J Cancer

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“…In addition, it failed to inhibit the growth of the tumours significantly, the tumour diameter in C. parvum treated animals 17 days after transplantation being 10-4 (9-.611.3) while that in untreated animals was 12-9 (11-8-14.2 (Mackay, 1964) and humans (Southam, 1968) with non-lymphomatous tumours. They contrast, however, with other observations in tumour bearing anim4ls (Kamo and Ishida, 1971) and patients (Litton, Hughes and Fulthorpe, 1964; Lee, Rowley and Mackay, 1970). It is thus apparent that the effect of tumours on humoral immunity is a variable one and difficult to predict with any certainty.…”

Section: The Effects Of Established Fibrosarcomata On Primary Humoralmentioning

confidence: 55%

The Effect of Transplanted Methylcholanthrene Induced Fibrosarcomata and Corynebacterium parvum on the Immune Response of CBA and A/HeJ Mice to Thymus Dependent and Independent Antigens

James¹,

Ghaffar²,

Milne³

1974

Br J Cancer

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Summary.-The effect of transplanted syngeneic methylcholanthrene induced fibrosarcomata on the primary immune response of CBA and A/HeJ mice to standard doses of alum BSA, SRBC and SIII has been investigated. In animals with established fibrosarcomata the responses were (with one exception) either normal or elevated. Cell transfer studies in sublethally irradiated syngeneic recipients confirmed that the spleens froim tumour bearing mice were capable of responding effectively to all 3 antigens. In animals simultaneously challenged with viable sarcoma cells and antigen the response to alum BSA was suppressed while those to SRBC and SIII were often enhanced. Furthermore the secondary response of A/HeJ mice to BSA was also suppressed by the simultaneous injection of viable fibrosarcoma cells. The administration of C. parvum 3 days after antigen had a variable effect. Nevertheless in a number of cases it significantly increased the primary response to all 3 antigens. It also inhibited the growth of the CBA fibrosarcoma but was without effect on the A/HeJ fibrosarcoma.

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“…3. Unlike the two groups of female rats, the carcinogen fed male rats showed a slightly better antibody response than the (Lytton et al, 1964;Krant et al, 1968), and surgical excision sometimes leads to recovery (Israel et al, 1968).…”

Section: Methodsmentioning

confidence: 99%

“…Here it is now well demonstrated that a depression of immune response is present, particularly in relation to cellular immunity (Hughes and Mackay, 1965;Brunschwig et al, 1965) and also in regard to circulating antibody production. However, in the latter case, depression occurs only at a late stage of the disease (Lytton et al, 1964).…”

mentioning

confidence: 95%

The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle

Young¹,

Cowan²,

Davidson³

1970

Br J Cancer

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SUMMARY.-Circulating antibody response to flagella antigen has been measured in three groups of Sprague-Dawley rats after feeding with 7.12.DMBA in an attempt to differentiate carcinogen and tumour growth as causative agents in the depression of immune response seen in these animals. DMBA fed female rats developing tumours had progressive depression of both primary and secondary response as compared to control animals, and 7S and 19S antibody fractions were equally affected. Removal of tumours did not result in recovery of response. Attempts to prevent tumour development by mammectomy after DMBA feeding were unsuccessful, but the similar number of tumours found in this group was associated with an equal degree of antibody depression to that seen in the first experiment. Male animals fed DMBA did not develop malignant tumours, and showed no depression of immune response. Results suggest that tumour development plays a part in the depression of circulating antibody response seen in these animals, but that it is not directly related to the number of tumours, and is not reversible by tumour excision.

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Circulating Antibody Response in Malignant Disease

Cited by 45 publications

References 8 publications

The incidence of allergic disorders and cancer.

The incidence of allergic disorders and cancer.

The Effect of Transplanted Methylcholanthrene Induced Fibrosarcomata and Corynebacterium parvum on the Immune Response of CBA and A/HeJ Mice to Thymus Dependent and Independent Antigens

The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle

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