Circulating Cytokines, Chemokines, and Stress Hormones are Increased in Patients with Organ Dysfunction Following Liver Resection

Kimura, Fumio; Shimizu, Hiroaki; Yoshidome, Hiroyuki; Ohtsuka, Masayuki; Kato, Atsushi; Yoshitomi, Hideyuki; Nozawa, Satoshi; Furukawa, Katsunori; Mitsuhashi, Noboru; Sawada, Shigeaki; Takeuchi, Dan; Ambiru, Satoshi; Miyazaki, Masaru

doi:10.1016/j.jss.2005.10.025

Cited by 57 publications

(56 citation statements)

References 58 publications

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“…Interestingly, we found two peaks of IL-6 and IL-8 elevation; the first peak was before islet infusion, and the second was after islet infusion. Since secretion of IL-6 and IL-8 is increased by major abdominal surgery (34,35), it seems reasonable to consider the first peak due to TP and the second peak due to AIT. IL-6 and IP-10 are major inflammatory cytokines, and IL-8 is a major chemokine; therefore, increases in those cytokines by both TP and AIT can deteriorate the outcome of AIT.…”

Section: Moberg Et Almentioning

confidence: 99%

Evidence for Instant Blood-Mediated Inflammatory Reaction in Clinical Autologous Islet Transplantation

Naziruddin

Iwahashi

Kanak

et al. 2014

American Journal of Transplantation

172

149

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y These authors contributed equally.A nonspecific inflammatory and thrombotic reaction termed instant blood-mediated inflammatory reaction (IBMIR) has been reported when allogenic or xenogenic islets come into contact with blood. This reaction is known to cause significant loss of transplanted islets. We hypothesized that IBMIR occurs in patients undergoing total pancreatectomy followed by autologous islet transplantation (TP-AIT) and tested this hypothesis in 24 patients and in an in vitro model. Blood samples drawn during the peritransplant period showed a significant and rapid increase of thrombinanti-thrombin III complex (TAT) and C-peptide during islet infusion, which persisted for up to 3 h, along with a decreased platelet count. A concomitant increase in levels of inflammatory proteins IL-6, IL-8 and interferoninducible protein-10 was observed. An in vitro model composed of pure islets plus autologous blood also demonstrated significantly increased levels of TAT (p < 0.05), C-peptide (p < 0.05), tumor necrosis factoralpha (p < 0.05) and MCP-1 (p < 0.05), as well as strong tissue factor expression in islets. Islet viability decreased significantly but was rescued by the presence of low-molecular-weight dextran sulfate. In conclusion, AIT-induced elevation of TAT and destruction of islets suggests that IBMIR might occur during AIT. Modulating this process may help improve islet engraftment and the insulin independence rate in TP-AIT patients.

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Section: Moberg Et Almentioning

confidence: 99%

Evidence for Instant Blood-Mediated Inflammatory Reaction in Clinical Autologous Islet Transplantation

Naziruddin

Iwahashi

Kanak

et al. 2014

American Journal of Transplantation

172

149

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“…Liver I/R and surgical injury causes induction of transcripts for the cytokines including IL-10, IL-1a,IL-1b, IL-1Ra, IL-18, IL-6, INF-b, MIF, IL-6, INF-g, TGF-b1, RANTES, major intrinsic protein MIP-1b, MIP-1a, MIP-2, IFN--inducible protein (IP)-10, MCP-1 and TCA-3 [77,78].…”

Section: Mif and Graft Rejectionmentioning

confidence: 99%

Macrophage-migration inhibitory factor: role in inflammatory diseases and graft rejection

Javeed

Zhao²

2008

Inflamm. res.

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Macrophage migration inhibitory factor (MIF) functions as a pleiotropic protein, participating in inflammatory and immune responses. MIF was originally discovered as a lymphokine involved in delayed hypersensitivity and various macrophage functions, including production of proinflammatory cytokines, glucocorticoid-induced immunomodulator, and natural killer cell inhibitory factor (NKIF), regulation of toll-like receptor expression, adherence and phagocytosis of macrophages, as well as induction of metalloproteinase. Therefore MIF is considered as a potential target protein in many pathophysiological states. In this review, considering the protein structure and the acting mechanisms of MIF, we mainly discuss the important role of MIF in pathogenesis of inflammatory diseases and graft rejection.

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“…It has been recently demonstrated that IL-6, -8, and -10 and cortisol increased significantly after partial hepatectomy in man and that these mediators correlate with postoperative infection and organ dysfunction [11]. All the abovementioned pro-and anti-inflammatory mediators may alter neutrophil functions.…”

Section: Discussionmentioning

confidence: 99%

“…The 14 patients (male=8, female=6) with an average age of 58±4 years had to undergo liver surgery because of malignant [11] and benign [3] liver tumors. Metachronous [7] or synchronous [2] metastatic liver disease from colorectal cancer was present in nine patients.…”

Section: Patients' Characteristicsmentioning

confidence: 99%

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Neutrophil phenotype and function in partial hepatectomy in man

Holzer

Hofmann

Oppermann

et al. 2010

Langenbecks Arch Surg

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Circulating Cytokines, Chemokines, and Stress Hormones are Increased in Patients with Organ Dysfunction Following Liver Resection

Cited by 57 publications

References 58 publications

Evidence for Instant Blood-Mediated Inflammatory Reaction in Clinical Autologous Islet Transplantation

Evidence for Instant Blood-Mediated Inflammatory Reaction in Clinical Autologous Islet Transplantation

Macrophage-migration inhibitory factor: role in inflammatory diseases and graft rejection

Neutrophil phenotype and function in partial hepatectomy in man

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