Circulating Levels of Allopregnanolone, an Anticonvulsant Metabolite of Progesterone, in Women with Partial Epilepsy in the Postcritical Phase

Galli, Renato; Luisi, M; Pizzanelli, Chiara; Monteleone, P.; Casarosa, Elena; Iudice, Alfonso; Murri, Luigi

doi:10.1046/j.1528-1157.2001.4220216.x

Cited by 7 publications

(8 citation statements)

References 26 publications

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“…ALLO may also play a role in the control of seizures through its ability to alter seizure susceptibility via modulation of GABAA receptor subunit composition. Animal studies have shown that changes in ALLO levels altered hippocampal subunit expression leading to altered GABAA receptor sensitivities [69].…”

Section: Anti-seizurementioning

confidence: 99%

Exogenous Progesterone: A Potential Therapeutic Candidate in CNS Injury and Neurodegeneration

Hu¹,

Li²,

Fang³

et al. 2009

CMC

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The role of progesterone (PROG) in the regulation of reproductive behavior is well understood, but a large and growing body of evidence indicates that this hormone also exerts neuroprotective effects on the central nervous system (CNS), i.e. in spinal cord injuries, traumatic brain injuries and in the age-related pathological process. Its neuroprotective actions, now well documented by experimental studies, make it a particularly promising therapeutic agent for neuroinjury and neurodegenerative diseases. The purpose of this article is to review recent preclinical and epidemiological evidences that exogenous administration of PROG or its metabolites plays an important role in the CNS. The diverse signaling mechanisms and the dose- dependent neuroprotective actions of PROG are also summarized. Awareness of the pleiotropic effects of PROG may open a novel perspective for the treatment of injuries and diseases in the nervous system. PROG could be produced in the brain by neurons and glial cells in the CNS of both male and female. Laboratories around the world have reported that administering relatively large doses of PROG during the first few hours or even days after injury significantly limits CNS damage, reduces loss of neuronal tissue and improves functional recovery. PROG appears to exert its protective effects by protecting or rebuilding the blood-brain barrier, decreasing the development of cerebral edema, down-regulating the inflammatory cascade, and limiting cellular necrosis and apoptosis. All these are plausible mechanisms of neuroprotection.

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Section: Anti-seizurementioning

confidence: 99%

Exogenous Progesterone: A Potential Therapeutic Candidate in CNS Injury and Neurodegeneration

Hu¹,

Li²,

Fang³

et al. 2009

CMC

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“…The neurosteroids and steroid neurometabolite allopregnanolone, which may correlate with a higher frequency of epileptic seizures. Several studies indicated a connection between the catamenial epilepsy and the disturbances in the biosynthesis of progesterone and its reduced-metabolites [22,24,25]. Progesterone and its derivatives are also suggested as anticonvulsant therapy [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy

Hill

Zárubová

Marusič

et al. 2010

The Journal of Steroid Biochemistry and Molecular Biology

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“…Despite this evidence, few data are currently available on the possible role of AP and PS in human epileptic disorders . One of the reasons for this still incomplete knowledge is the difficulty in quantifying with high specificity the neuroactive steroids by currently available methods .…”

mentioning

confidence: 99%

Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus

et al. 2016

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Neuroactive steroids are increasingly considered as relevant modulators of neuronal activity. Especially allopregnanolone (AP) and pregnenolone sulfate (PS) have been shown to possess, respectively, anticonvulsant or proconvulsant properties. In view of the potential role of these steroids, we aimed at evaluating AP and PS levels in cerebrospinal fluid (CSF) and blood samples obtained from patients with status epilepticus (SE). To this purpose, we enrolled 41 patients affected by SE and 41 subjects investigated for nonepileptic neurologic disorders. Liquid chromatographic procedures coupled with electrospray tandem mass spectrometry and routine laboratory investigations were performed. Significantly lower AP levels were found in the CSF of patients affected by SE (-30%; p < 0.05, Mann-Whitney test). Notably, AP was not detectable in 28 of 41 patients affected by SE (p < 0.01 vs. controls, Fisher's exact test). In serum, AP levels did not differ in the two considered groups. Conversely, PS was present at similar levels in the investigated groups. Finally, differences in AP levels could not be explained by a variation in CSF albumin content. These findings indicate that AP is defective in the CSF of patients affected by SE. This phenomenon was not dependent on carriers for steroids, such as albumin.

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Circulating Levels of Allopregnanolone, an Anticonvulsant Metabolite of Progesterone, in Women with Partial Epilepsy in the Postcritical Phase

Cited by 7 publications

References 26 publications

Exogenous Progesterone: A Potential Therapeutic Candidate in CNS Injury and Neurodegeneration

Exogenous Progesterone: A Potential Therapeutic Candidate in CNS Injury and Neurodegeneration

Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy

Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus

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