Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index

Stengel, Andreas; Hofmann, Tobias; Goebel-Stengel, Miriam; Elbelt, Ulf; Kobelt, Peter; Klapp, Burghard F.

doi:10.1016/j.peptides.2012.11.014

Cited by 372 publications

(397 citation statements)

References 20 publications

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“…Consistent with this hypothesis, circulating irisin levels are elevated in obese humans and positively correlate with serum insulin (Stengel et al. 2013). These findings are supported by previous studies indicating that irisin levels are increased during obesity in both rodents and humans (Stengel et al.…”

Section: Discussionmentioning

confidence: 99%

“…These findings are supported by previous studies indicating that irisin levels are increased during obesity in both rodents and humans (Stengel et al. 2013; Lopez‐Legarrea et al. 2014; Wu et al.…”

Section: Discussionmentioning

confidence: 99%

“…reported a positive correlation between body weight and circulating irisin in obese humans (Stengel et al. 2013). Our results also support Wu et al.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, plasma irisin levels are positively associated with body mass index (Stengel et al. 2013) as well as fat mass (Pardo et al. 2014).…”

Section: Introductionmentioning

confidence: 99%

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Increased FNDC5 is associated with insulin resistance in high fat-fed mice

et al. 2017

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FNDC5/irisin, has recently been identified as a novel protein that stimulates the “browning” of white adipose by inducing thermogenesis via increased uncoupling protein 1 (UCP1). We tested the hypothesis that high fat diet‐induced prediabetic mice would exhibit increased FNDC5 and this effect would be attenuated by chronic exercise. C57BL/6 mice were randomized into three groups for the 4 week intervention: Standard diet (Std, n = 12), High fat diet (HF, n = 14), or High fat diet and free access to a running wheel (HFEX, n = 14). Body weight, glucose, insulin, and the homeostatic model assessment of insulin resistance (HOMA‐IR) were greater in HF compared to Std and HFEX after the 4 week intervention. In support of our hypothesis, FNDC5 was higher in HF in both skeletal muscle and adipose compared to Std and was lower in adipose only in HFEX compared to HF mice. Following the same pattern, PGC‐1α was significantly higher in HF compared to Std in skeletal muscle and significantly lower in HFEX compared to HF in adipose. UCP1 was significantly lower in HFEX versus Std (in skeletal muscle) and versus HF (in adipose). HOMA‐IR was significantly correlated with FNDC5 protein levels in adipose. Increased FNDC5 in adipose and skeletal muscle may be a compensatory mechanism to offset high fat diet‐induced weight gain and insulin resistance by increasing energy expenditure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…reported a positive correlation between body weight and circulating irisin in obese humans (Stengel et al. 2013). Our results also support Wu et al.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, plasma irisin levels are positively associated with body mass index (Stengel et al. 2013) as well as fat mass (Pardo et al. 2014).…”

Section: Introductionmentioning

confidence: 99%

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Increased FNDC5 is associated with insulin resistance in high fat-fed mice

et al. 2017

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“…The sample size of the current trial was base on the equation published by Mera et al (1998) to detect differences for irisin between obese and normal-weight patients as well as the changes after the diet-induced weight loss and taking into account published values of circulating irisin standard deviation (Huh et al, 2012;Stengel et al, 2012). It was calculated for an effect size 0.5, an a 5 0.05, and a power (1 2 b) of 80%.Thus, the sample size was established at a minimum of 26 volunteers per group to detect differences according to the adiposity levels and 66 obese subjects who finished the nutritional intervention.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras

Pardo

Roca-Rivada

et al. 2013

American J Hum Biol

129

117

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Objective: The recently discovered peptide irisin has been hypothesized to be a regulator of body metabolism. The objective of this work was to evaluate whether circulating human irisin levels are modulated by body size and changes in adiposity during an energy restriction treatment and the subsequent weight regain.Methods: A group of 94 obese patients (50 men, 44 women; 49.4 6 9.4 years; BMI 35.6 6 4.5 kg/m 2 ) participated in a weight loss program following an 8-week hypocaloric diet (230% energy expenditure) with a weight maintenance follow-up. The patients were evaluated at 0, 8, and 24 weeks after starting treatment. In addition, 48 normal-weight subjects (16 men, 32 women; 35.71 6 8.8 years; BMI 22.9 6 2.2 kg/m 2 ) participated as controls. Plasma irisin, body weight, body composition, and hormones controlling energy homeostasis were measured.Results: Irisin levels were higher in obese subjects (353.1 6 18.6 ng/mL) than in those of normal-weight (198.4 6 7.8 ng/mL; P 0.001) and were also higher in men (340.9 6 20 ng/mL) than in women (267.6 6 12 ng/mL; P < 0.05). Moreover, irisin plasma levels were significantly correlated with high levels of direct and indirect adiposity markers, such as weight, BMI, waist circumference, and fat mass, as measured by bioimpedance, but not with height or leptin levels. Interestingly, irisin levels paralleled body weight reduction after the dietary treatment (week 8) and again returned to the baseline levels at 24 weeks in those patients regaining the lost weight.Conclusions: Irisin strongly reflects body fat mass, suggesting that the irisin circulating levels are conditioned by adiposity level. Am. J. Hum. Biol. 26:198-207, 2014.

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Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity?

Ulaş

Acar

et al. 2023

Brain and Behavior

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Introduction: Restless legs syndrome (RLS) is a common but underdiagnosed neurological syndrome. It is characterized by the feeling of discomfort and desire to move, especially in the lower extremities, which often occurs at night, and the cure or relief of symptoms with movement. Irisin is a hormonelike polypeptide that was first identified in 2012, weighs 22 kDa, consists of 163 amino acids, and is mainly synthesized in muscle. Its synthesis increases with exercise. Here in this study, we planned to investigate the relationship among serum irisin level, physical activity, lipid profile, and RLS. Material and methods:A total of 35 patients with idiopathic RLS and 35 volunteers were included in the study. Then, venous blood was taken from the participants in the morning after 12 h of night fasting. Results:The mean value of serum irisin level was 16.9 ± 14.1 ng/mL in the case group and 5.1 ± 5.9 ng/mL in the control group, which was statistically quite significant (p < .001). A significant efficiency (under the curve area 0.886 [0.804-0.967]) of irisin value was observed in the differentiation of patients in the case and control groups.Discussion: Serum irisin level was significantly higher in the case group than in the control group. In conclusion, we suggest that irisin may play a role in the pathophysiology of RLS independently of the intensity and duration of physical activity and anthropometric data, such as body weight, body mass index, and waist/hip ratio.

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Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index

Cited by 372 publications

References 20 publications

Increased FNDC5 is associated with insulin resistance in high fat-fed mice

Increased FNDC5 is associated with insulin resistance in high fat-fed mice

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Investigation of the relationship between serum irisin level in the idiopathic restless legs syndrome: Could be a marker independent of physical activity?

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