Circulating lipid peroxidation and antioxidant status in cervical cancer patients: a case-control study

Vaiyapuri, Manju; Sailaja, J. Kalaivani; Nalini, Namasivayam

doi:10.1016/s0009-9120(02)00376-4

Cited by 86 publications

(69 citation statements)

References 27 publications

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“…Namely, higher levels of LOOH as well as the LOOH/GPx ratio were recorded in all examined groups over those in controls, except for patients with polypus endometrii. The observed changes are in accordance with other findings where elevated lipid peroxidation was reported for patients with uterine cervicitis or myoma (Chiou and Hu, 1999) or cancer patients (Manju et al, 2002;Kolanjiappan et al, 2002). We also observed that circulating levels of lipid hydroperoxides and LOOH/GPx ratio are generally higher in subjects with either form of hyperplasia or adenocarcinoma than those found in polypus or myoma patients.…”

Section: Discussionsupporting

confidence: 93%

Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium

et al. 2006

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Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid hydroperoxides level was negatively correlated to superoxide dismutase and glutathione peroxidase activities, as well as positively correlated to catalase activity. In addition, the lipid hydroperoxides/ glutathione peroxidase ratio was found to be increased, according to the type of uterine disease. The obtained results show that perturbation of antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myoma.

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Section: Discussionsupporting

confidence: 93%

Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium

et al. 2006

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“…This indicates that GST may not appear to play a role in drug resistance (18). GST levels were found to be decreased in uterine cervical carcinoma (3,19) and in fibroadenoma and adenocarcinoma of breast (16). An increase in GST in oral tumor tissue has been reported by Saroja et al (2,10).…”

Section: The Mean + Sd Values Of Glutathione (Gsh) Malondlaldehyde (mentioning

confidence: 63%

Oxidant-antioxidant status in colorectal cancer patients—Before and after treatment

Upadhya

Mohan

Vanajakshamma

et al. 2004

Indian J Clin Biochem

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Erythrocyte antioxidant glutathione and malondialdehyde levels in erythrocytes and plasma glutathione S-transferase levels were estimated in patients with colorectal cancer and compared to controls. Further, the patients underwent four weeks of radiotherapy with adjuvant chemotherapy. The same parameters were estimated after four weeks of radiotherapy and compared.with pretreatment levels. It was observed that there was a decrease in erythrocyte glutathione and malondialdehyde levels in patients with colorectal cancer compared to controls, but not in case of GST. However, after chemoradiotherapy, there were no statistically significant differences in all the parameters studied.

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“…The results of the studies on cancers other than head and neck squamous cell carcinomas and the results of the current study are consistent with very high levels of oxidative stress present in malignant tissue, resulting in higher lipid peroxidation and accumulation of lipid peroxidation products. These increased lipid peroxides may also be related to deficiency of superoxide dismutase (SOD) in tumor tissues [36]. SOD is an antioxidant enzyme which has been found to be responsible for the protection against ROS-mediated lipid peroxidation [37].…”

Section: Discussionmentioning

confidence: 99%

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

Korde¹,

Basak

Chaudhary³

et al. 2011

Oncology

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Objective: Interaction between reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a crucial determinant in the etiology of oral squamous cell carcinoma (OSCC), and antioxidants protect against cellular and molecular damage caused by these. This study aims to evaluate ROS and RNS, together with the total antioxidant capacity (TAC), in serum and tissues of OSCC patients. Method: Total nitric oxide (TNO), malondialdehyde (MDA), and TAC were evaluated using a UV visible spectrophotometer in the serum of 30 controls, 30 precancer and 30 OSCC patients and in tissues of 10 controls and 30 OSCC patients. Results: MDA and TNO were significantly elevated with concomitant depletion of TAC in serum and tissues of OSCC patients when compared to controls. A significant positive correlation (p = 0.01), at different levels between TNO and MDA in OSCC patients, was found, which increased with the grade of OSCC. Conclusion: An increase in the levels of TNO, NO-mediated lipid peroxidation, resulting in an increase in MDA levels, the positive TNO-MDA correlation with a deranged antioxidant defense system as demonstrated by significantly low levels of TAC; when all these facts are taken together, we can conjecture that oxidative DNA damage, a vital phenomenon for carcinogenesis, occurs due to the interplay of ROS, RNS and TAC.

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Circulating lipid peroxidation and antioxidant status in cervical cancer patients: a case-control study

Cited by 86 publications

References 27 publications

Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium

Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium

Oxidant-antioxidant status in colorectal cancer patients—Before and after treatment

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

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