Circulating plasma miR-155 is a potential biomarker for the detection of SARS-CoV-2 infection

Haroun, Riham Abdel-Hamid; Osman, Waleed H.; Amin, Rasha E.; Hassan, Abbas; Abo-Shanab, Walefed S.; Eessa, Asmaa M.

doi:10.1016/j.pathol.2021.09.006

Cited by 43 publications

(40 citation statements)

References 31 publications

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“…A study showed that elevated miR-155 expression levels in COVID-19 patients were significantly correlated with clinicopathological features (eg, chest CT, CRP, ferritin, D-dimer, WBC count, and lymphocyte and neutrophil percentages) in COVID-19 patients, with a significant increase in WBC count and neutrophil count and a significant decrease in lymphocyte count in COVID-19 patients. 52 It was found that knocking out the miR-155 gene in mice can reduce the pulmonary inflammatory response caused by influenza virus, 53 and inhibition of the miR-155/NF-κB pathway was found to be effective in alleviating the inflammatory response, 54 so the changes in the clinicopathological characteristics of COVID-19 patients may be controlled by the miR-155/NF-κB pathway. There was also a significant correlation between ALP, CREA, and DBIL and differentially expressed miRNAs, which may predict the involvement of these miRNAs in the regulation of liver and kidney function.…”

Section: Discussionmentioning

confidence: 99%

Potential Predictive Value of miR-125b-5p, miR-155-5p and Their Target Genes in the Course of COVID-19

Li¹,

Wang²,

Zhou³

et al. 2022

IDR

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Purpose This study aimed to provide new biomarkers for predicting the disease course of COVID-19 by analyzing the dynamic changes of microRNA (miRNA) and its target gene expression in the serum of COVID-19 patients at different stages. Methods Serum samples were collected from all COVID-19 patients at three time points: the acute stage, the turn-negative stage, and the recovery stage. The expression level of miRNA and the target mRNA was measured by Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR). The classification tree model was established to predict the disease course, and the prediction efficiency of independent variables in the model was analyzed using the receiver operating characteristic (ROC) curve. Results The expression of miR-125b-5p and miR-155-5p was significantly up-regulated in the acute stage and gradually decreased in the turn-negative and recovery stages. The expression of the target genes CDH5, STAT3, and TRIM32 gradually down-regulated in the acute, turn-negative, and recovery stages. MiR-125b-5p, miR-155-5p, STAT3, and TRIM32 constituted a classification tree model with 100% accuracy of prediction and AUC >0.7 for identification and prediction in all stages. Conclusion MiR-125b-5p, miR-155-5p, STAT3, and TRIM32 could be useful biomarkers to predict the time nodes of the acute, turn-negative, and recovery stages of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Potential Predictive Value of miR-125b-5p, miR-155-5p and Their Target Genes in the Course of COVID-19

Li¹,

Wang²,

Zhou³

et al. 2022

IDR

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“…microRNA Clinical samples References Diagnosis markers hsa-miR-10b, hsa-miR-21, hsa-miR-155, hsa-miR-208a, hsa-miR-499, hsa-miR-29a-3p, hsa-miR-146a, hsa-miR-155-5p, hsa-miR-2392, hsa-miR-155, hsa-miR-19a-3p, hsa-miR-19b-3p, hsa-miR-92a-3p, hsa-miR-150-5p, hsa-miR-375, hsa-miR-122-5p, hsa-miR-494-3p, hsa-miR-3197, hsa-miR4690-5p, hsa-miR-1915-3p and hsa-miR-3652 COVID-19 v.s healthy control [69,89,[91][92][93] hsa-miR-106b-5p, hsa-miR-221-3p, hsa-miR25-3p, hsa-miR-30a-5p COVID-19 v.s Community-acquired pneumonias [88] hsa-miR-155, hsa-miR-208a, hsa-miR-499 COVID-19 v.s Influenza-ARDS [90] Prognosis markers miR-nsp3-3p, hsa-miR-320a/b/c, hsa-miR-200c, hsa-miR-155 Mild/moderate patients v.s severe patients [80,89,96,97] hsa-miR-29a-3p, hsa-miR-146a-3p…”

Section: Table 2 Circulating Mirnas Identified As Biomarkers For Diag...mentioning

confidence: 99%

The emerging role of miRNAs in the pathogenesis of COVID-19: Protective effects of nutraceutical polyphenolic compounds against SARS-CoV-2 infection

Yang¹,

Chen²,

Liu³

et al. 2022

Int. J. Med. Sci.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause immunosuppression and cytokine storm, leading to lung damage and death. The clinical efficacy of anti-SARS-CoV-2 drugs in preventing viral entry into host cells and suppressing viral replication remains inadequate. MicroRNAs (miRNAs) are crucial to the immune response to and pathogenesis of coronaviruses, such as SARS-CoV-2. However, the specific roles of miRNAs in the life cycle of SARS-CoV-2 remain unclear. miRNAs can participate in SARS-CoV-2 infection and pathogenesis through at least four possible mechanisms: 1. host cell miRNA expression interfering with SARS-CoV-2 cell entry, 2. SARS-CoV-2-derived RNA transcripts acting as competitive endogenous RNAs (ceRNAs) that may attenuate host cell miRNA expression, 3. host cell miRNA expression modulating SARS-CoV-2 replication, and 4. SARS-CoV-2-encoded miRNAs silencing the expression of host protein-coding genes. SARS-CoV-2-related miRNAs may be used as diagnostic or prognostic biomarkers for predicting outcomes among patients with SARS-CoV-2 infection. Furthermore, accumulating evidence suggests that dietary polyphenolic compounds may protect against SARS-CoV-2 infection by modulating host cell miRNA expression. These findings have major implications for the future diagnosis and treatment of COVID-19.

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“…2 a-A1, 2a-A2). In this connection, the disrupted expression of some above-mentioned miRNAs such as miR-223, miR-17, miR-130a, miR-15a, miR-31, miR-16, miR-124, miR-146a, miR-218, miR-126-3p (reduced), and miR-155 (elevated) were reported in the circulation of patients with the COVID-19 [170] , [171] , [173] , [174] , [175] , [176] , [193] , [194] , [195] , [196] , [197] , [198] , [199] . The downregulated level of miR-34a was also observed in the post-mortem lung biopsy of patients with severe forms of the disease [163] .…”

Section: Mirnasmentioning

confidence: 99%

“…2 c-E). In this regard, the non-optimal circular expression levels of some of these miRNAs such as miR-150, miR-218, miR-494-3p, miR-20b (reduced), and miR-155 (elevated) have been observed in patients with the COVID-19 [173] , [193] , [196] , [199] , [222] . Furthermore, the indirect effects of the miRNAs on the other pathways/events ( e.g ., neutrophils/monocytes activities, NETosis, and hypoxia/hypoxemia) ( Fig.…”

Section: Mirnasmentioning

confidence: 99%

Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation

Mortazavi-Jahromi

Aslani

2022

International Immunopharmacology

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Circulating plasma miR-155 is a potential biomarker for the detection of SARS-CoV-2 infection

Cited by 43 publications

References 31 publications

Potential Predictive Value of miR-125b-5p, miR-155-5p and Their Target Genes in the Course of COVID-19

Potential Predictive Value of miR-125b-5p, miR-155-5p and Their Target Genes in the Course of COVID-19

The emerging role of miRNAs in the pathogenesis of COVID-19: Protective effects of nutraceutical polyphenolic compounds against SARS-CoV-2 infection

Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation

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