Circulatory adipocytokines and lipid profile variations in type-2 diabetic subjects: Desirable side-effects of antidiabetic drugs

Ghadge, Abhijit A.; Harke, Shubhangi; Khadke, Suresh; Diwan, Arundhati; Pankaj, Madhu; Kulkarni, Omkar; Ranjekar, P. K.; Kuvalekar, Aniket

doi:10.1016/j.dsx.2014.09.010

Cited by 16 publications

(8 citation statements)

References 17 publications

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“…The improvement in lifestyle with good dietary habits and regular exercise may help in managing the physiological effects of the antidiabetic drugs. The recent report from this laboratory has indicated that the commonly prescribed antidiabetic drugs have a desirable effect on secretion and levels of adipocytokines which are now considered as important therapeutic targets [23]. In continuation of this, the present study also revealed several novel and interesting key findings in diabetic subjects receiving antidiabetic drugs.…”

Section: Discussion ▼supporting

confidence: 72%

Effects of Commonly Used Antidiabetic Drugs on Antioxidant Enzymes and Liver Function Test Markers in Type 2 Diabetes Mellitus Subjects – Pilot Study

Ghadge

Harke

Khadke

et al. 2015

Exp Clin Endocrinol Diabetes

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Section: Discussion ▼supporting

confidence: 72%

Effects of Commonly Used Antidiabetic Drugs on Antioxidant Enzymes and Liver Function Test Markers in Type 2 Diabetes Mellitus Subjects – Pilot Study

Ghadge

Harke

Khadke

et al. 2015

Exp Clin Endocrinol Diabetes

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“…Many studies have been conducted related to the use of oral antidiabetic drugs. [3][4][5] Therefore, many people choose to use traditional medicine that is accepted to be safer, affordable, and effective. 6,7 Mountain papaya (Vasconcellea pubescens A.DC.)…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Sasongko¹,

Lestari²,

Yugatama³

et al. 2020

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Introduction: Mountain papaya (Vasconcellea pubescens A.DC.) and bitter melon (Momordica charantia L.) fruit extract have total flavonoids and some metabolite from its contains. The use of a single dose in the treatment of diabetes is often considered to lack a strong effect. Giving a combination of the compound is a solution to provide a synergistic effect in treatment. Material and Methods: Rat were divided into eight groups (normal, negative control, glibenclamide as a positive control, and five dose extract group). The single dose mountain papaya extract (MPE) and bitter melon extract (BME) were given at 174 mg/kg b.w of MPE, and 380 mg/kg b.w of BME in oral administration.

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“…White adipose tissue is an endocrine organ that secretes a variety of adipokines that promotes cross-talk within diverse organs (e.g., heart, muscle, and bone marrow). Adipokines are tightly associated with energy balance ( Argilés et al, 2005 ; Ghadge et al, 2014 ). For example, adiponectin regulates lipid and glucose metabolism ( Smitka and Marešová, 2015 ), whereas leptin modulates ingestion and energy expenditure ( Szewczyk-Golec et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Metformin Mitigates Fibrosis and Glucose Intolerance Induced by Doxorubicin in Subcutaneous Adipose Tissue

et al. 2018

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Doxorubicin (DX) is a chemotherapeutic drug that is used in clinical practice that promotes deleterious side effects in non-tumor tissues such as adipose tissue. We showed that DX leads to extensive damage in adipose tissue via a disruption in 5′-adenosine monophosphate-activated protein kinase (AMPK) and PPAR-gamma signaling. Thus, we investigated whether co-treatment with the biguanide drug metformin (MET) could prevent the side effects of DX through the activation of AMPK in adipose tissue. The goal of the present study was to verify the effects of DX and adjuvant MET treatment in subcutaneous adipose tissue (SAT) and to determine whether MET could protect against chemotherapy-induced side effects. C57/BL6 mice received DX hydrochloride (2.5 mg/kg) intraperitoneally 2 times per week for 2 weeks (DX), concomitantly or not, with MET administration (300 mg/kg oral daily) (DX + MET). The control group (CTRL) was pair-fed according to the food consumption of the DX group. After euthanasia, adipose tissue fat pads were collected, and SAT was extracted so that adipocytes could be isolated. Glucose uptake was then measured, and histological, gene, and protein analyses were performed. One-way analysis of variance was also performed, and significance was set to 5%. DX reduced retroperitoneal fat mass and epididymal pads and decreased glycemia. In cultured primary subcutaneous adipocytes, mice in the DX group had lower glucose uptake when stimulated with insulin compared with mice in the CTRL group. Adipocytes in the DX group exhibited a reduced area, perimeter, and diameter; decreased adiponectin secretion; and decreased fatty acid synthase gene expression. SAT from MET-treated mice also showed a reduction in collagen deposition. Treatment with MET prevented fibrosis and restored glucose uptake in SAT after insulin stimulation, yet the drug was unable to prevent other side effects of DX such as tissue loss and inflammatory response.

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Circulatory adipocytokines and lipid profile variations in type-2 diabetic subjects: Desirable side-effects of antidiabetic drugs

Cited by 16 publications

References 17 publications

Effects of Commonly Used Antidiabetic Drugs on Antioxidant Enzymes and Liver Function Test Markers in Type 2 Diabetes Mellitus Subjects – Pilot Study

Effects of Commonly Used Antidiabetic Drugs on Antioxidant Enzymes and Liver Function Test Markers in Type 2 Diabetes Mellitus Subjects – Pilot Study

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Metformin Mitigates Fibrosis and Glucose Intolerance Induced by Doxorubicin in Subcutaneous Adipose Tissue

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