Circulatory effects in man of nortriptyline, a tricyclic antidepressant drug

Freyschuss, U.; Sjöqvist, Folke; Tuck, Dick; Åsberg, Marie

doi:10.1007/bf00420708

Cited by 47 publications

(17 citation statements)

References 11 publications

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“…That these reactions are more likely to occur in the presence of existing cardiovascular disease is illustrated in Table 2, which summarizes a study in which the average daily dose of imipramine was 100 mg (range 75-200 mg) (28). Additional studies (65)(66)(67) have shown variable results, which in part appear due to factors such as drug dosage, patient selection and methodology. For example, no significant orthostatic hypotension was noted in depressed patients when blood pressure was measured 3 weeks after initiation of therapy (65), yet when recordings were made during the first 72 hr of treatment, a postural fall of greater than 20 mm Hg systolic was noted in 23%.…”

Section: Cardiovascular Effects At Therapeutic Levels In Manmentioning

confidence: 95%

A Review of the Cardiovascular Effects and Toxicity of Tricyclic Antidepressants

Jefferson

1975

Psychosomatic Medicine

227

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The tricyclic antidepressants have potent and complex effects on the cardiovascular system, both directly and through interactions with other drugs. Through a combination of anticholinergic activity, direct myocardial depressant activity and an effect on the adrenergic neuron, they can cause a combination of arrhythmias, blood pressure abnormalities and congestive heart failure. These changes, although most common with overdose, can occur at therapeutic levels. In addition a number of drug-drug interactions can occur between the tricyclics and agents used in the treatment of cardiovascular disease, as exemplified by tricyclic antagonism of the antihypertensive effect of guanethidine. Awareness of these factors is necessary to insure proper therapeutic utilization of the tricyclics as well as to treat effectively their toxicity.

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Section: Cardiovascular Effects At Therapeutic Levels In Manmentioning

confidence: 95%

A Review of the Cardiovascular Effects and Toxicity of Tricyclic Antidepressants

Jefferson

1975

Psychosomatic Medicine

227

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“…In the clinical medicine, it was reported that the cardiac side effects were induced by tricyclic anti-depressant treatment in depressed patients (Edwards 1964;Freyschuss et al 1970; Moir et al 1972). Therefore, it is of interest to investigate the effect of DMI on the SA node in situ of the dog heart.…”

mentioning

confidence: 99%

Effect of desmethylimipramine on the canine SA node.

Chiba

1974

Tohoku J. Exp. Med.

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“…The increases of pulse rate correspond to what is observed in patients receiving the usual t.i.d. dosage (Freyschuss et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

“…It is mainly a question of rhythm distur bances which may cause cardiac failure and death. Also in the clinical use of the substances in the ordinary 3-times-a-day dosage cardiac side effects in the form of conduction distur bances and cases of tachycardia have been observed (Freyschuss et al, 1970;Vohra et al, 1975).…”

Section: Introductionmentioning

confidence: 99%

ECG Changes during Treatment with Nortriptyline in a Once-a-Day Dosage

Nielsen¹

1980

Neuropsychobiology

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In 21 patients suffering from endogenous depression and given nortriptyline 150 mg/day for 4 weeks in a once-a-day dosage an electrocardiographic study was made with ECG recordings at different times during the treatment. At the same time the plasma concentration of nortriptyline was determined. During the treatment the heart rate increased significantly, both at the minimum and the maximum concentration of nortriptyline. At the maximum concentration the PQ interval increased significantly. None of the patients developed an A-V block. 3 patients developed extrasystoles. None of the patients had severe subjective symptoms. All finished the trial as planned. There was no correlation between the plasma concentration of nortriptyline and the increase in heart rate. The trial revealed no serious cardiac influence during treatment with nortriptyline in a once-a-day dosage.

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Circulatory effects in man of nortriptyline, a tricyclic antidepressant drug

Cited by 47 publications

References 11 publications

A Review of the Cardiovascular Effects and Toxicity of Tricyclic Antidepressants

A Review of the Cardiovascular Effects and Toxicity of Tricyclic Antidepressants

Effect of desmethylimipramine on the canine SA node.

ECG Changes during Treatment with Nortriptyline in a Once-a-Day Dosage

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