Cisplatin-Based Neoadjuvant Chemotherapy and Combined Resection for Ethmoid Sinus Adenocarcinoma Reaching and/or Invading the Skull Base

Nasal and paranasal sinus carcinoma: Are we making progress?

“…The close relation between survival and local control underscores the fact that the prognosis for patients with nasal and paranasal sinus carcinoma is related directly to local control of the disease. 4,5,103,117,154,157,174,186,196 In the literature, global results, most often expressed in terms of crude survival, vary between 10% 60,61,63,70,77,80,82,152 and 75%, 40,106,109,132,135,160,161,165,176 with better results in carefully selected patients, in patients with primary tumors of the nasal cavity, and in more recently published articles. The average over- all survival rate from the systematic review analysis was 41%, and the overall survival rate for the 1990s was 51%.…”

Results of endoscopic resection followed by radiotherapy for primarily diagnosed adenocarcinomas of the paranasal sinuses

“…Global results of such series cannot be compared. We found that only 5 studies specifically deal with ethmoidal adenocarcinomas 21,[33][34][35][36] (Table 3). Our results for overall, disease-specific, and recurrence-free survival are in the range of published results.…”

“…[13][14][15][16][17][18][19] Postoperative radiotherapy is nearly always arranged. In some French centers, however, the treatment protocol differs; Roux, 20 Brasnu et al, 21 and George et al 22 published their results after treatment with neoadjuvant chemotherapy, followed by resection of the tumor. In Canada, Waldron et al 23 starts the treatment with radiotherapy, followed by surgery.…”

Gamma Knife Radiosurgery for Skull Base Metastasis and Invasion

“…Skull base metastasis occurs in the cavernous sinus region [8] and other skull base regions [2,9]. The available treatment methods for skull base metastasis and invasion include surgical resection [10], irradiation and/or chemotherapy [3,5,10]. Fractionated radiotherapy has been the most effective method both as a primary treatment [4] and for recurrence after surgical resection [10].…”