Class D OXA-48 Carbapenemase in Multidrug-Resistant Enterobacteria, Senegal

Moquet, Olivier; Bouchiat, Coralie; Kinana, Alfred; Seck, Abdoulaye; Arouna, Omar; Bercion, Raymond; Breurec, Sébastien; Garin, Benoît

doi:10.3201/eid1701.100244

Cited by 77 publications

(20 citation statements)

References 9 publications

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“…For example, ESBL producers accounted for 5.2% of community‐acquired urinary tract infections caused by Escherichia coli in Senegal [23], 19.3% of Enterobacteriaceae in the Central African Republic [24], 32.9% of Enterobacteriaceae in Tanzania [25], 26.9% of Enterobacteriaceae in India [26] and 36.6% of E. coli in Cambodia [27]. In addition, as carbapenems are often the most effective antibiotics used against 3GC‐R Enterobacteriaceae , the emergence of carbapenem resistance, a phenomenon that has been described in Africa [28], but that was not found in our study, could become a serious challenge for infection control and antibiotic therapy in the future.…”

Section: Resultsmentioning

confidence: 99%

Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258

Breurec

Nathalie

Timinouni

et al. 2013

Clinical Microbiology and Infection

107

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The molecular epidemiology of third-generation cephalosporin-resistant (3GC-R) Klebsiella pneumoniae in developing countries is poorly documented. From February 2007 to March 2008, we collected 135 3GC-R K. pneumoniae isolates from seven major towns in Maghreb (Morocco), West Africa (Senegal, Côte d'Ivoire), Central Africa (Cameroon), East Africa (Madagascar) and Southeast Asia (Vietnam). Their genetic diversity, assessed by multilocus sequence typing, was high (60 sequence types), reflecting multiclonality. However, two major clonal groups, CG15 (n = 23, 17% of isolates) and CG258 (n = 18, 13%), were detected in almost all participating centres. The two major clonal groups have previously been described in other parts of the world, indicating their global spread. The high diversity of enterobacterial repetitive intergenic consensus sequence-PCR banding patterns at the local level indicates that most isolates were epidemiologically unrelated. The isolates were characterized by the presence of multiple resistance determinants, most notably the concomitant presence of the aac(6')-Ib-cr, qnr and blaCTX-M-15 genes in 61 isolates (45%) belonging to 31 sequence types. These isolates were detected across a large geographical area including Cameroon (n = 1), Vietnam (n = 4), Madagascar (n = 10), Côte d'Ivoire (n = 12), Morocco (n = 13) and Senegal (n = 21). These results have major implications for patient management and highlight a potential reservoir for resistance determinants.

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Section: Resultsmentioning

confidence: 99%

Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258

Breurec

Nathalie

Timinouni

et al. 2013

Clinical Microbiology and Infection

107

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“…). In Africa, they have been mainly identified in the northern countries (Morocco, Algeria, Tunisia, Egypt, and Libya) , but OXA‐48 producers have also been identified in Senegal and South Africa (Fig. ).…”

Section: The Carbapenem‐hydrolysing Class D β‐Lactamases (Chdls)mentioning

confidence: 99%

The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide

Nordmann

Poirel

2014

Clinical Microbiology and Infection

620

497

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The spread of carbapenemase producers in Enterobacteriaceae has now been identified worldwide. Three main carbapenemases have been reported; they belong to three classes of β-lactamases, which are KPC, NDM, and OXA-48. The main reservoirs of KPC are Klebsiella pneumoniae in the USA, Israel, Greece, and Italy, those of NDM are K. pneumoniae and Escherichia coli in the Indian subcontinent, and those of OXA-48 are K. pneumoniae and Escherichia coli in North Africa and Turkey. KPC producers have been mostly identified among nosocomial isolates, whereas NDM and OXA-48 producers are both nosocomial and community-acquired pathogens. Control of their spread is still possible in hospital settings, and relies on the use of rapid diagnostic techniques and the strict implemention of hygiene measures.

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“…Considering carbapenemase production among E. coli isolates in the African continent, although many descriptions have been reported in humans (Robin et al 2010;Moquet et al 2011;Barguigua et al 2013;Leski et al 2013;Mushi et al 2014) and the hospital environment (Chouchani et al 2011) over the last 5 years, it has not been until very recently when the first carbapenemaseproducing E. coli was detected in pets (Yousfi et al 2016) and livestock animals (Braun et al 2016). The previously described study, conducted in different dairy cattle farms from Egypt, reported four E. coli strains harbouring bla OXA-48 and one carrying bla OXA-181 carbapenemase genes, all of them phenotypically resistant to meropenem and imipenem.…”

Section: Esbl Plasmid-mediated Ampc and Carbapenemase-producing E Cmentioning

confidence: 99%

Antibiotic resistance in Escherichia coli in husbandry animals: the African perspective

Alonso

Zarazaga

Sallem

et al. 2017

Letters in Applied Microbiology

138

106

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In the last few years, different surveillances have been published in Africa, especially in northern countries, regarding antimicrobial resistance among husbandry animals. Information is still scarce, but the available data show a worrying picture. Although the highest resistance rates have been described against tetracycline, penicillins and sulphonamides, prevalence of plasmidmediated quinolone resistance genes and extended spectrum b-lactamase (ESBL) are being increasingly reported. Among ESBLs, the CTX-M-1 group was dominant in most African surveys. Within this group, CTX-M-15 was the main variant both in animals and humans, except in Tunisia where CTX-M-1 was more frequently detected among Escherichia coli from poultry. Certain bla CTX-M-15 -harbouring clones (ST131/B2 or ST405/D) are mainly identified in humans, but they have also been reported in livestock species from Tanzania, Nigeria or Tunisia. Moreover, several reports suggest an inter-host circulation of specific plasmids (e.g. bla CTX-M-1 -carrying IncI1/ST3 in Tunisia, IncY-and Incuntypeable replicons co-harbouring qnrS1 and bla CTX-M-15 in Tanzania and the worldwide distributed bla CTX-M-15 -carrying IncF-type plasmids). International trade of poultry meat seems to have contributed to the spread of other ESBL variants, such as CTX-M-14, and clones. Furthermore, first descriptions of OXA-48-and OXA-181-producing E. coli have been recently documented in cattle from Egypt, and the emergent plasmid-mediated colistin resistance mcr-1 gene has been also identified in chickens from Algeria, Tunisia and South Africa. These data reflect the urgent need of a larger regulation in the use of veterinary drugs and the implementation of surveillance programmes in order to decelerate the advance of antimicrobial resistance in this continent.

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Class D OXA-48 Carbapenemase in Multidrug-Resistant Enterobacteria, Senegal

Cited by 77 publications

References 9 publications

Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258

Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258

The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide

Antibiotic resistance in Escherichia coli in husbandry animals: the African perspective

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