Clear cell chondrosarcoma of the pelvis in a skeletally immature patient

Ishida, Toru; Yamamoto, Masahiro; Goto, Takahiro; Kawano, Hirotaka; Yamamoto, Aiichiro; Machinami, Rikuo

doi:10.1007/s002560050519

Cited by 14 publications

(7 citation statements)

References 8 publications

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“…b Axial T2W FSE (TE 160, TR 5,500) image demonstrates that the signal in the superior layer is now high (black arrow and the inferior layer is low (white arrow) Table 2 The prevalence of The presence of the L/H SI pattern on T1W images is significantly contributed to by lesions that are primary ABC (n=24/50) or contain secondary ABC change (21/50). Secondary ABC formation can occur in SBC [23], fibrous dysplasia [21], GCT [1,18], osteosarcoma, may be relatively frequent in chondroblastoma (4/5 cases [11]),and rarely in clear cell chondrosarcoma [42]. Such lesions are relatively frequent in this group: SBC, n=4; chondroblastoma, n=6; GCT, n=5; osteosarcoma, n=6.…”

Section: Discussionmentioning

confidence: 93%

Fluid-fluid levels in bone neoplasms: variation of T1-weighted signal intensity of the superior to inferior layers—diagnostic significance on magnetic resonance imaging

Alyas

Saifuddin

2008

Eur Radiol

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The diagnostic relevance of the relative T1-weighted (T1W) and T2-weighted (T2W)/short tau inversion recovery (STIR) MRI signal intensity characteristics of the superior to inferior fluid layers within fluid-fluid levels (FFLs) found in bone tumours was investigated. A retrospective analysis was performed of MRI studies of 2,568 patients presenting with a suspected bone tumour over an 8-year period. Final diagnosis was made by biopsy/surgical resection or characteristic imaging/clinical findings. Subjects were divided by the absence/presence of FFLs and benign/malignant histology. Cases with FFLs were sub-categorised by the relative signal intensity of the superior/inferior layer as high/low or low/high on T1W and T2W/STIR sequences. Out of the total of 2,568 cases, 214 (8.3%, CI 7.3-9.5%) had FFLs and 2,354 (91.7%, CI 90.5-92.7%) had no FFLs. All 214 cases with FFLs had T2W/STIR sequences available, all demonstrating high/low signal intensity characteristics; 135/214 (63.1%, CI 56.2-69.6%) were benign and 79/214 (36.9%, CI 30.4-43.8%) were malignant. Out of the 214 patients, 151 had T1W sequences performed; 52 showed high/low signal intensity, of which 30 (57.7%, CI 34.2-71.3%) were benign and 22 (42.3%, CI 28.7-56.8%) were malignant (P = 0.06 compared with no FFL group); 50 showed low/high signal intensity, of which 40 (80%, CI 66.3-90.0%) were benign and ten (20%, CI 10.0-33.7%) were malignant (P = 0.0000, compared with the no FFL group). The low/high and high/low groups had a significantly greater proportion of benign and malignant lesions, respectively (P = 0.015). In conclusion, all FFLs showed high/low signal intensity characteristics on T2W/STIR sequences. Low/high signal on T1W was significantly associated with benign disease. Malignancy may occur slightly more frequently with high/low signal on T1W.

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Section: Discussionmentioning

confidence: 93%

Fluid-fluid levels in bone neoplasms: variation of T1-weighted signal intensity of the superior to inferior layers—diagnostic significance on magnetic resonance imaging

Alyas

Saifuddin

2008

Eur Radiol

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“…The youngest patient in a series of 47 cases from the Mayo Clinic was 14 years of age [3]. In a review of the English language literature, the youngest reported case of a CCCS occurred in the pelvis of a skeletally immature 12-year-old boy in Japan [8]. No other reports of CCCS occurring in skeletally immature individuals were found.…”

Section: Case Reportmentioning

confidence: 99%

“…However, CCCS most commonly occurs in the third to fifth decade, whereas chondroblastoma occurs in the first and second decades [3,12]. The previously published case in a 12-year-old boy occurred in the pelvis, not the classic epiphyseal location [8]. Thus, CCCS has not traditionally been included in the differential diagnosis of epiphyseal lesions in skeletally immature patients.…”

Section: Case Reportmentioning

confidence: 99%

Clear cell chondrosarcoma mimicking chondroblastoma in a skeletally immature patient

et al. 2002

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“…[7]199944 × LGN/AN/AN/A–––––Ishida et al. [45]199911 × LGNED11R00–0––Nathan et al. [46]19991N/AN/AN/AN/A–––––Ayoub at al.…”

Section: Resultsmentioning

confidence: 99%

Clear cell chondrosarcoma is an underestimated tumor: Report of 7 cases and meta-analysis of the literature

Klein¹,

Tauscher²,

Birkenmaier³

et al. 2019

Journal of Bone Oncology

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IntroductionClear cell chondrosarcoma (CCC) is a rare subtype of chondrosarcoma and it is commonly considered a low-grade tumor and less aggressive than atypical cartilaginous tumor (grade 1 central chondrosarcoma). However, the experience even of musculoskeletal tumor centres with this rare entity is limited. The aim of this study is to analyse our own treatment results and those of the literature regarding the therapy and outcome of this lesion.Material and Methods7 cases of CCC have been treated in our department between 2003 and 2015. Their follow-up data were collected retrospectively. 187 literature cases with histopathological and clinical characteristics were retrieved by means of a PubMed search with the key word “clear cell chondrosarcoma”. The data pertaining to treatment and follow up were extracted. We analysed the survival of patient and the risk factors for local recurrence (LR) as well as metastatic disease (MD).ResultsThe mean age at the time of diagnosis was 40 years. Two thirds of the patients were male. The mean follow-up time was 109 months. To our surprise, there was a high rate of LR (30%) and of MD (20%) when compared to low-grade conventional chondrosarcomas. 15% of LR and 20% of metastatic disease were observed after more than 10 years follow-up. Uncommon locations of MD such as in the spine is a unique observation in chondrosarcomas and underlines the high aggressiveness of this tumor. 10-year overall survival was almost 80%, 10-years disease free survival 60%. Positive margins (p = 0.038) and metastases (p = 0.006) impaired the overall survival significantly. The rate of local recurrence was significantly dependent on resection margin (p < 0.001); however there was no correlation with the grade of differentiation of the tumor. The development of MD was affected by local recurrence (p = 0.006), but we could not detect a significant association with margin status (p = 0.184).ConclusionsA wide resection is the advocated treatment option. Long term follow-up for at least 10 years is necessary in order to not overlook late LR or MD. This work demonstrates for the first time the apparent aggressiveness of the CCC.

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Clear cell chondrosarcoma of the pelvis in a skeletally immature patient

Cited by 14 publications

References 8 publications

Fluid-fluid levels in bone neoplasms: variation of T1-weighted signal intensity of the superior to inferior layers—diagnostic significance on magnetic resonance imaging

Fluid-fluid levels in bone neoplasms: variation of T1-weighted signal intensity of the superior to inferior layers—diagnostic significance on magnetic resonance imaging

Clear cell chondrosarcoma mimicking chondroblastoma in a skeletally immature patient

Clear cell chondrosarcoma is an underestimated tumor: Report of 7 cases and meta-analysis of the literature

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