Clear differences in adiponectin level and glutathione redox status revealed in obese and normal-weight patients with psoriasis

Kaur, Sirje; Zilmer, Kersti; Kairane, Česlava; Kals, Mart; Zilmer, Mihkel

doi:10.1111/j.1365-2133.2008.08759.x

Cited by 82 publications

(85 citation statements)

References 15 publications

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“…It seems that obesity in psoriatic patients could be connected to decreased protective influence of adiponectin and with enhanced systemic inflammatory process and oxidative stress [72]. Coimbra et al [73] achieved similar results.…”

Section: Adiponectinsupporting

confidence: 67%

“…[57,63,74,75]. Most of this protein is synthesized in adipocytes, though some minor quantities are found in placenta, ovaries, skeletal muscles, stomach, liver and pituitary gland [60,72].…”

Section: Leptinmentioning

confidence: 99%

“…Kaur et al [72] investigated the correlation between adiponectin, body weight and oxidative stress. Obese patients with psoriasis had a significantly higher concentration of IL-6, which additionally was negatively correlated with adiponectin concentration.…”

Section: Adiponectinmentioning

confidence: 99%

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Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

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Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2-3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.

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Section: Adiponectinsupporting

confidence: 67%

Section: Leptinmentioning

confidence: 99%

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Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

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“…Çalışmamızda hastalık süresi ve hastalık başlangıç yaşı ile AN düzeyi arasında ilişki bulunmadı. Kaur ve arkadaşlarının çalışmasında normal kilodaki psoriazis hastalarında AN düzeyinin sağlıklı normal kilolu kontrol grubuna göre iki kat yüksek olduğu, ancak obez psoriazis hastalarındaki AN düzeyinin normal kilodaki psoriazis hastalarına göre anlamlı olarak düşük olduğu gözlenmiştir 26 . Takahashi ve ark.…”

Section: Discussionunclassified

“…Çalışmamızda kilosu normalin üstündeki psoriazis hastalarında, normal kiloda olanlara göre daha düşük AN düzeyi saptandı. Psoriaziste düşük AN düzeyi tespit edilen çalışmalarda, bu durumun psoriazisteki metabolik sendromla ilişkili komorbiditelerin patogenezinde önemli olabileceği ve komorbiditelerin azaltılması için yeni tedavi yaklaşımları geliştirmede katkıda bulunabileceği üzerinde durulmaktadır [23][24][25][26][27] . Sonuç olarak psoriaziste serum AN düzeyinin önemi ve metabolik sendrom gibi komorbiditelerin göstergesi olabileceği, ayrıca hastalık şiddetinin değerlendirilmesinde kullanılabileceği vurgulanmıştır.…”

Section: Discussionunclassified

Psoriaziste adiponektin düzeyi ve hastalık şiddeti ile ilişkisi

Tutkun¹,

Gül²,

Erdoğan³

et al. 2014

TURKDERM

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ÖzetAmaç: Psoriazis patogenezi tam olarak anlaşılamamış kronik inflamatuvar bir hastalıktır. Adipositlerden üretilen adiponektinin (AN) antidiyabetik, antiaterojenik ve antiinflamatuvar etkileri olduğu gösterilmiştir. Son yıllarda yapılan çalışmalarda metabolik sendrom düşük AN düzeyi ile ilişkilendirilmiştir. Literatürde az sayıda çalışmada psoriaziste AN düzeyi araştırılmıştır. Çalışmamızda psoriazisli olgularda AN düzeyini ve hastalık şiddeti ile ilişkisini araştırmayı amaçladık. Gereç ve Yöntem: Çalışmamıza 46 psoriazis vulgarisli hasta ile yaş ve cinsiyet uyumlu 40 sağlıklı kontrol grubu dahil edildi. Hastaların dermatolojik muayeneleri yapıldı, psoriazis alan ve şiddet indeksi (PAŞİ) hesaplandı. Her 2 grupta demografik özellikler sorgulandı ve vücut kitle indeksi belirlendi. Serum AN ve CRP düzeyleri her iki grupta ölçüldü ve istatistiksel olarak karşılaştırıldı. Bulgular: Ortalama serum AN düzeyleri hasta grubunda kontrol grubuna göre daha düşük saptandı; ancak istatistiksel olarak anlamlı değildi. Serum AN düzeyi yaş, hastalık başlangıç yaşı ve hastalık süresi ile ilişkili bulunmadı. Psoriazis hastalarında CRP arttıkça, serum AN düzeyinin düştüğü tesbit edildi. PAŞİ arttıkça AN düzeyinde istatistiki olarak anlamlı azalma gözlendi. PAŞİ ile vücut kitle indeksi arasında istatistiki bir ilişki gözlenmedi. Sonuç: Psoriaziste AN düzeyi, metabolik sendrom ile birlikteliğinin bir göstergesi olabilir. Ayrıca psoriaziste hastalık şiddetinin değerlendirilmesinde de kullanılabilir; ancak adiponektinin psoriazis patogenezindeki rolü ve bu ilişkinin netlik kazanması için ayrıntılı incelemeleri içeren, farklı klinik modellerle yapılmış çalışmalara ihtiyaç vardır. Sum maryBackground and Design: Psoriasis is a chronic inflammatory disease in which the pathogenesis has not been completely understood yet. Adiponectin (AN) produced by adipocytes has antidiabetic, antiatherogenic and anti-inflammatory effects. Recent studies demonstrated that metabolic syndrome is related with low levels of AN. In the literature, there have been a few studies investigating AN levels in psoriasis. In this study, we purposed to investigate AN levels in patients with psoriasis. Materials and Methods: Forty-six patients with psoriasis and 40 age-and sex-matched healthy controls were included in our study. Dermatological examinations were performed and psoriasis area severity index (PASI) was calculated. In both groups, demographic features were questioned and body mass index were defined. Serum AN and C-reactive protein (CRP) levels were determined in both groups and were compared statistically. Results: The mean serum AN levels in patients were lower than in controls, but no statistically significant difference was detected between the groups. Serum levels of AN were not found to be associated with age, age at disease onset and disease duration. It was demonstrated that

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Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

Gustafsson

Lind

Söderberg

et al. 2013

Obesity

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Objective: Previous epidemiological studies together with animal studies have suggested an association between adiponectin and oxidative stress and inflammation, but community-based studies are lacking. Our objective was to investigate the relative importance of oxidative stress and inflammatory markers, representing different pathways in relation to adiponectin. Design and Methods: In a cross-sectional sample of 929 70-year-old individuals (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors study, relations between serum adiponectin and oxidative stress [conjugated dienes (CD), homocysteine, total antioxidant capacity, oxidized low-density lipoprotein (OxLDL), OxLDL antibodies, baseline CD of LDL, glutathione (GSH), total glutathione (TGSH), glutathione disulfide], circulation interleukins (IL-6, IL-8), other cytokines [tumor necrosis factor a, monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor], cell adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, P-selectin, L-selectin), and systemic inflammatory markers [C-reactive protein (CRP), leukocyte count] in separate models were investigated. Results: In age-and sex-adjusted, as well as multivariable-adjusted models, adiponectin was significantly and positively associated with GSH, log TGSH, whereas an inverse association was observed for CD and log EGF. An inverse association between adiponectin and MCP-1, log E-selectin, and log CRP was significant in age-and sex-adjusted models, but not in multivariable-adjusted models. Conclusions: Our results imply that higher levels of adiponectin are associated with a more beneficial oxidative stress profile, with higher levels of principal anti-oxidative GSH and total GSH together with lower levels of lipid peroxidation, possibly through shared pathways. Further studies are needed to investigate whether changes in the oxidative stress profile may be a mechanism linking adiponectin with type 2 diabetes and/or cardiovascular disease.

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Clear differences in adiponectin level and glutathione redox status revealed in obese and normal-weight patients with psoriasis

Cited by 82 publications

References 15 publications

Biochemical markers of psoriasis as a metabolic disease

Biochemical markers of psoriasis as a metabolic disease

Psoriaziste adiponektin düzeyi ve hastalık şiddeti ile ilişkisi

Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin

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