Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants

3,6‐Epidioxy‐1,10‐bisaboladiene inhibits G1‐specific transcription through Swi4/Swi6 and Mbp1/Swi6 via the Hog1 stress pathway in yeast

“…EDBD has been shown to exert cytotoxic effects in various cancer cell lines, including HBC-5 (breast), HT-29 (colon), NCI-H522 (lung) and Lox-IMVI (melanoma) cells [16]. Furthermore, EDBD induces apoptosis via activation of p38 MAPK in HL60 cancer cells, a well-characterized, p53-null cell line [27].…”

“…Next, because EDBD has been shown to induce apoptosis [16], we sought to determine whether EDBD inhibited cell growth by affecting mitochondrial function. To this end, we employed dihydroartemisinin (DHA), a derivative of the antimalarial drug artemisinin, which contains an endoperoxide moiety within its structure [17,18].…”

“…Furthermore, EDBD shows antitumor effects in a xenograft model of melanoma (Lox-IMVI cells) in vivo [16]. However, the mechanism through which EDBD exerts these antitumor effects remains unclear.…”

“…In our previous studies, EDBD was found to have cytotoxic activity (half-maximal inhibitory concentration [IC 50 ] = 3.4 lM) and to induce apoptosis via activation of p38 mitogen-activated protein kinase (MAPK) in the human promyelocytic leukemia cell line HL60. Furthermore, EDBD shows antitumor effects in a xenograft model of melanoma (Lox-IMVI cells) in vivo [16]. However, the mechanism through which EDBD exerts these antitumor effects remains unclear.…”

Anti-thrombotic and anti-tumor effect of water extract of caulis of <i>Sargentodoxa cuneata</i> (Oliv) Rehd et Wils (Lardizabalaceae) in animal models

“…Cancer is a very serious medical condition worldwide. The current medical treatments for cancer including chemotherapy and radiotherapy, often have serious side effects [5,6]. Therefore, it is very important to develop much safer antithrombotic and anti-tumor agents with fewer side effects.…”