Clemontanoside-C, a saponin from Clematis montana

Thapliyal, R. P.; Bahuguna, R. P.

doi:10.1016/0031-9422(93)85471-3

Cited by 22 publications

(13 citation statements)

References 5 publications

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“…The fungitoxic effects of aqueous extracts of most plant species tested in the present work indicate the importance of many plant species as a natural source of antimycotic substances (Table 1) (major active constituents present are indicated [14–60]). Antifungal activity of medicinal plants, e.g.…”

Section: Discussionmentioning

confidence: 93%

Antifungal activity of plant extracts against dermatophytes

Ali‐Shtayeh

Ghdeib

1999

Mycoses

255

107

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The aqueous extracts (15 micrograms ml-1 medium) of 22 plants used in folkloric medicine in Palestine were investigated for their antifungal activity and minimum inhibitory concentrations (MICs) against nine isolates of Microsporum canis, Trichophyton mentagrophytes and Trichophyton violaceum. The extract of the different plant species reduced colony growth of the three dermatophytes by 36 to 100% compared with the control treatment. Antimycotic activity of the extract against the three dermatophytes varied significantly (P < 0.05) between test plants. Extracts of Capparis spinosa and Juglans regia completely prevented growth of M. canis and T. violaceum. The most active extracts (90-100% inhibition) were those of Anagallis arvensis, C. spinosa, J. regia, Pistacia lentiscus and Ruta chalapensis against M. canis; Inula viscosa, J. regia and P. lentiscus against T. mentagrophytes; and Asphodelus luteus, A. arvensis, C. spinosa, Clematis cirrhosa, I. viscosa, J. regia, P. lentiscus, Plumbago europea, Ruscus aculeatus, Retema raetam and Salvia fruticosa against T. violaceum. The MICs of these most active plants ranged from 0.6 to 40 micrograms ml-1. The three dermatophytes differed significantly with regard to their susceptibility to plant extracts. Trichophyton violaceum was the most susceptible being completely inhibited by 50% of the extracts followed by M. canis and T. mentagrophytes which were completely inhibited by only 23 and 14% of the extracts, respectively.

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Section: Discussionmentioning

confidence: 93%

Antifungal activity of plant extracts against dermatophytes

Ali‐Shtayeh

Ghdeib

1999

Mycoses

255

107

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“…Among these, triterpenoids saponins, flavonoids and lignans Kawata et al (2001), Kizu and Tomimori (1979), Shao et al (1995) 5 Kawata et al (2001), Kizu and Tomimori (1979), Shao et al (1995) 6 Prosaponin CP 1 R¼ Ara C. chinensis Kizu and Tomimori (1980a) Kizu and Tomimori (1980a) Kizu and Tomimori (1980b) Kizu and Tomimori (1980b), Shao et al (1995) 10 Prosaponin CP8a R¼ Glc(1-4)Xyl(1-3)Rha(1-2)Ara C. chinensis Kizu and Tomimori (1982a) Sati et al (1990), Song et al (1997), Yan et al (2009) Uniyal and Sati (1992) 22 Thapliyal and Bahuguna (1993a) …”

Section: Chemical Constituentsmentioning

confidence: 96%

The genus Clematis (Ranunculaceae): Chemical and pharmacological perspectives

Chawla

Kumar

Sharma

2012

Journal of Ethnopharmacology

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“…Many secondary metabolites were obtained from different plant parts of different Clematis L. species. Clemontanoside-C, a new hederagenin-based saponin, was extracted from C. montana stem (Thapliyal and Bahuguna 1993 ) . Two new hederagenin 3,28-O-bisdesmosides known as clematibetosides A and C along with another new one clematibetoside B (gypsogenin 3,28-O-bisdesmoside) were detected from aerial parts of C. tibetana (Kawata et al 2001 ) .…”

Section: Clematis Sppmentioning

confidence: 99%

Contribution of Biotechnological Tools in the Enhancement of Secondary Metabolites in Selected Medicinal Climbers

Srivastava

Singh

Misra

2015

Biotechnological Strategies for the Conservation of Medicinal and Ornamental Climbers

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Plants by nature protect themselves by producing secondary metabolites which often have pronounced bioactivities. The presence of these metabolites is responsible for the active interaction of plants with their environment defending themselves against a variety of herbivores and pathogenic microorganisms as well as various kinds of abiotic stresses. Climber plants contain large number of useful secondary metabolites. Besides their pharmacological role, secondary metabolites also contain some other properties. Artabotrys hexapetalus , a climbing herb, secretes oil which is used in perfume industry. Capparis zeylanica is a thorny stout climbing shrub, used in the treatment of snake bite and to cure small pox, cholera, etc. Stem barks and roots of Tinospora cordifolia , a woody climber, are used in dysentery and diarrhoea. Toddalia asiatica , an evergreen climber, produced nitidine secondary metabolite which contains anti-HIV and antimalarial and anticancerous properties, but its production is not enough for commercial supply. Tissue culture technology has emerged as a supplementary branch to fulfi l demands for this valuable secondary metabolite. Various in vitro methods for enhancement of secondary metabolites are available such as hairy root culture, treatment of elicitors and use of precursors and introduction of any foreign gene via bacterial transformation.Current progresses have been made in the fi eld of molecular biology through the alteration in metabolic skeleton of plant secondary metabolism. With the use of various genes (involved in the synthesis of enzymes and their regulatory proteins), diverse pathways have been traced and being transformed. Antisense technology has been emerged as an additional alternative for enhancement of secondary metabolites. In Tylophora indica enhancement in kaempferol, an antioxidant compound was observed by using precursors like salicylic acid, ornithine, cinnamic acid, tyrosine and phenylalanine. The total dry weight of 2-hydroxy-4-methoxy benzaldehyde was enhanced in hairy root cultures of Decalepis hamiltonii . The present chapter provides an insight on the use of biotechnological techniques for the enhancement of secondary metabolites in medicinal climbers.

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Clemontanoside-C, a saponin from Clematis montana

Cited by 22 publications

References 5 publications

Antifungal activity of plant extracts against dermatophytes

Antifungal activity of plant extracts against dermatophytes

The genus Clematis (Ranunculaceae): Chemical and pharmacological perspectives

Contribution of Biotechnological Tools in the Enhancement of Secondary Metabolites in Selected Medicinal Climbers

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