This paper presents the results of a study focused on the projected changes in extreme precipitation during the 21st century in Central Serbia. The changes are investigated on the basis of historical and modelled data sets of daily precipitation. The historical observation data were recorded at 18 synoptic weather stations in Central Serbia and modelled data were extracted from the regional climate model EBU-POM (Eta Belgrade University-Princeton Ocean Model) under the A1B scenario. The average number of days in a year with precipition ≥ 20, 30, 40 and 50 mm (R20, R30, R40 and R50), the share of daily precipitation above the 20, 30, 40 and 50 mm (P20, P30, P40, P50) in the total annual precipitation and the monthly distribution of these heavy daily precipitation are used as indices of changes in extreme precipitation. These indices, for the three periods 2011–2040, 2041–2070 and 2071–2100, are determined and compared with those obtained for the historical reference period 1961–1990. The results have shown that the main changes in extreme precipitation in Central Serbia will be in their spatial distribution, and the uncertainty of the occurrence of extreme events will decrease. In the future the increase will be more pronounced than the decrease of these indices. We strongly emphasize the benefit of this paper for both the prevention of natural disasters in the study area and for the improvement of the regional climate model.