Clinical and epidemiological data of patients with clonorchiasis

Wang, Ke-xia; Zhang, Rongbo; Cui, Yubao; Tian, Ye; Cai, Rong; Chao-pin, LI

doi:10.3748/wjg.v10.i3.446

Cited by 34 publications

(23 citation statements)

References 25 publications

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“…Increasing inland fish production causes a local increase in the number of food-borne trematode infections, and increasing international travel, human migration, food trade, and changing eating habits may cause an increase in the number of cases diagnosed in countries where the disease is not endemic (363)(364)(365). Infections with liver and lung flukes are rarely fatal, but the burden of disease is considerable, and moreover, C. sinensis and O. viverrini infections may lead to cholangiocarcinoma (366,367). Although Fasciola spp., Paragonimus spp., and intestinal flukes are found worldwide, higher rates of transmission are known for certain areas, such as the Andean region, Africa, and Asia (366).…”

Section: Food-borne Trematodesmentioning

confidence: 99%

Molecular Testing for Clinical Diagnosis and Epidemiological Investigations of Intestinal Parasitic Infections

2014

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SUMMARY Over the past few decades, nucleic acid-based methods have been developed for the diagnosis of intestinal parasitic infections. Advantages of nucleic acid-based methods are numerous; typically, these include increased sensitivity and specificity and simpler standardization of diagnostic procedures. DNA samples can also be stored and used for genetic characterization and molecular typing, providing a valuable tool for surveys and surveillance studies. A variety of technologies have been applied, and some specific and general pitfalls and limitations have been identified. This review provides an overview of the multitude of methods that have been reported for the detection of intestinal parasites and offers some guidance in applying these methods in the clinical laboratory and in epidemiological studies.

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Section: Food-borne Trematodesmentioning

confidence: 99%

Molecular Testing for Clinical Diagnosis and Epidemiological Investigations of Intestinal Parasitic Infections

2014

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“…Unlike opisthorchiasis acute infections with Clonorchis spp. are typically clinically asymptomatic or with subtle, nonspecific complaints [23]. However, particularly in travelers, an acute syndrome with right upper quadrant pain, nausea, and occasional fever or cough may develop [23, 24].…”

Section: Eosinophilia In the Short Term Travelermentioning

confidence: 99%

Eosinophilia in Infectious Diseases

O’Connell

Nutman

2015

Immunology and Allergy Clinics of North America

107

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“…Clonorchis sinensis, the causative agent of human clonorchiasis, is an important endemic parasite and a major cause of disease risk among 35 million people living in parts of Asia including Korea, China, Taiwan and Vietnam (Rim 2005;Wang et al 2004;Yu et al 2003). Infection with C. sinensis occurs after consumption of raw or undercooked freshwater fish containing metacercariae (Keiser and Utzinger 2005).…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of a novel 21.6-kDa tegumental protein from Clonorchis sinensis

et al. 2011

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Tegumental proteins form a membrane-bound outer surface and are thus involved in host-parasite interactions and parasite survival. A complementary DNA clone encoding a novel 21.6-kDa tegumental protein (CsTegu21.6, accession number JF911532) was identified in a sequence library for the adult Clonorchis sinensis liver fluke. The complete coding sequence was 564 bp and encoded a protein of 188 amino acids. A BLASTX search revealed identities from 43 to 47% with previously identified tegumental proteins in C. sinensis and other helminthic parasites. Multiple alignment of the amino acids of CsTegu21.6 with those of four other C. sinensis tegumental proteins, CsTegu21.1, CsTegu22.3, CsTegu20.8 and CsTegu31.8, revealed pair-wise sequence identities ranging from 24 to 31.8%. A calcium-binding EF-hand domain containing a basic helix-loop-helix structure at the N terminus and a dynein light chain domain at the C terminus were found in CsTegu21.6; these motifs are common in tegumental proteins. CsTegu21.6 was specifically observed on the tegument of adult worms using immunolocalization analysis.

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Clinical and epidemiological data of patients with clonorchiasis

Cited by 34 publications

References 25 publications

Molecular Testing for Clinical Diagnosis and Epidemiological Investigations of Intestinal Parasitic Infections

Molecular Testing for Clinical Diagnosis and Epidemiological Investigations of Intestinal Parasitic Infections

Eosinophilia in Infectious Diseases

Identification and characterization of a novel 21.6-kDa tegumental protein from Clonorchis sinensis

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