Clinical and experimental studies of bone tissue in fl uorosis

Abstract

Introduction. Despite the signifi cant reduction in the production of electrolytic aluminum, the frequency of fl uorosis is a leader in this industry. In this pathology, fi rst of all, bone tissue actively reacts to the impact of factors of the working environment. The aim of the study was to study the eff ect of chronic fl uoride intoxication on the morphofunctional state of bone tissue. Materials and methods. Th e analysis of bone mineral density, structural rearrangement of skeletal bones was evaluated by x-ray method using photon densitometry. Biochemical status of blood of workers with fl uorosis included determination of parameters of mineral homeostasis (level of calcium, phosphorus) and genetic markers (COL1A1, IL1β, IL6, VEGF). Histological analysis of bone tissue was carried out in an experiment on white rats.Results. A comprehensive clinical and experimental study of bone tissue under chronic fl uoride intoxication is presented. A signifi cant correlation of GG COL1A1, TT IL1β, GC IL6, GC VEGF genotypes with the development of osteosclerosis was revealed. Th e study showed the relationship of combined signs of fl uorosis, confi rmed by experimental data on persistent bone destruction.Conclusions. Th e leading clinical and radiological syndrome of industrial fl uorosis is the defeat of the musculoskeletal system against the background of gross violations of the morphological and functional structure of the bones of the skeleton, due to the osteotropic mechanism of action of fl uorides and the genetic status of the body.