Clinical and histopathological comparison of microneedling combined with platelets rich plasma versus fractional erbium-doped yttrium aluminum garnet (Er: YAG) laser 2940 nm in treatment of atrophic post traumatic scar: a randomized controlled study

Agamia, Naglaa; Sorror, Osama Ahmed; Alrashidy, M; Tawfik, Abeer Attia; Badawi, Ashraf

doi:10.1080/09546634.2020.1729334

Cited by 12 publications

(9 citation statements)

References 19 publications

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“…The results of treatment with laser, laser and PRP, micro‐needling, micro‐needling, and PRP, and PRP alone were evaluated, respectively from six (Abdel Aal et al., 2018; Agamia et al., 2020; El‐Taieb et al., 2019; Faghihi et al., 2016; Galal et al., 2019; Gawdat et al., 2014), five (Abdel Aal et al., 2018; El‐Taieb et al., 2019; Faghihi et al., 2016; Galal et al., 2019; Gawdat et al., 2014), four (Asif et al., 2016; El‐Domyati et al., 2018; Elfar & Hasby, 2020; Ibrahim et al., 2017), six (Asif et al., 2016; El‐Domyati et al., 2018; Elfar & Hasby, 2020; Gawdat et al., 2014; Ibrahim et al., 2017; Nofal et al., 2014), and five (El‐Taieb et al., 2019; Elfar & Hasby, 2020; Hodeib et al., 2018; Ibrahim et al., 2017; Nofal et al., 2014) out of 13 articles.…”

Section: Resultsmentioning

confidence: 99%

“…Platelet‐rich plasma was administered intradermally in 15 studies and topically in 9. Studies were conducted in four different countries namely, Iran (Faghihi et al., 2016), India (Arsiwala et al., 2020; Asif et al., 2016; Chawla, 2014; Deshmukh & Belgaumkar, 2019; Gawdat et al., 2014; Kar & Raj, 2017), Egypt (Abdel Aal et al., 2018; Abdel‐Maguid et al., 2019; Agamia et al., 2020; Bhargava et al., 2019; El‐Domyati et al., 2018; El‐Taieb et al., 2019; Elfar & Hasby, 2020; Galal et al., 2019; Hassan et al., 2020; Hewedy et al., 2020; Hodeib et al., 2018; Ibrahim et al., 2017; Nofal et al., 2014), and South Korea (Lee et al., 2011; Min et al., 2018).…”

Section: Resultsmentioning

confidence: 99%

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Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Ebrahimi

Alimohamadi

Janani

et al. 2022

J Tissue Eng Regen Med

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Despite the rising trend for applying platelet‐rich plasma (PRP) in the management of various types of scars, there is no convincing evidence supporting its use. This motivated us to review the randomized clinical trials that examine the effectiveness and safety of PRP, alone or in combination with other methods, for the management of atrophic or hypertrophic/keloidal scars. The Web of Science, Scopus, Google Scholar, and Cochrane Library databases were systematically searched until September 1st, 2020. Thirteen clinical trials were enrolled in the meta‐analysis, and 10 more were reviewed for their results. The random effect meta‐analysis method was used to assess the effect size of each outcome for each treatment type, and I2 was used to calculate the statistical heterogeneity between the studies. Patients treated with PRP experienced an overall response rate of 23%, comparable to the results seen with laser or micro‐needling (22% and 23%, respectively) When used alone, moderate improvement was the most frequently observed degree of response with PRP (36%) whereas, when added to laser or micro‐needling, most patients experienced marked (33%, 43%, respectively) or excellent (32% and 23%, respectively) results. Concerning the hypertrophic/keloid scars, the only study meeting the required criteria reported a better improvement and fewer adverse effects when PRP was added to the intralesional corticosteroids. Platelet‐rich plasma appears to be a safe and effective treatment for various types of atrophic scars. In addition, when added to ablative lasers or micro‐needling, it seems to considerably add to the efficacy of treatment and reduce the side effects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Ebrahimi

Alimohamadi

Janani

et al. 2022

J Tissue Eng Regen Med

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“… 6–63 Combination treatment with laser, PRP, subcision, glycolic acid peel, Jessner’s peel, trichloroacetic acid peel and topical amniotic fluid stem cells resulted in greater scar improvement than MN or FRF-MN alone. 8 , 17 , 24 , 26 , 31 , 32 , 34 , 37 , 40 , 51 , 53 , 55 Fifty to 100% of patients were satisfied with MN or FRF-MN treatment; 33% of patients reported they would want further treatment, 9 while 94% would recommend treatment to others. 28 Combining treatment with 1550 nm laser or PRP resulted in higher patient satisfaction.…”

Section: Resultsmentioning

confidence: 99%

Microneedling for the Treatment of Scars: An Update for Clinicians

Juhász

Cohen

2020

CCID

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Background Microneedling (MN) is used for the treatment of scars, amongst other indications. Although used in Asia and the Middle East for decades, related to the supposed lack of post-procedure pigmentary alterations even in darker skin types, MN only recently gained attention in the United States as an effective, well-tolerated aesthetic treatment. Materials and Methods A systematic review of the Medline database was completed using search terms “microneedle” or “microneedling” or “micro needle” or “micro needling” and “scar”. Included articles were written in English and discussed the use of MN for the treatment of scars in human subjects. Results Fifty-eight studies were included for review, with a total of 1845 patients treated for acne scarring, hypertrophic or keloid scars, and those resulting from surgery, trauma, varicella or smallpox. MN and its counterpart fractional radiofrequency MN (FRF-MN) were used as monotherapy or in combination with topical, surgical or systemic modalities. MN and FRF-MN treatment resulted in clinical improvement of scar appearance from baseline. No serious adverse events occurred. Conclusion MN is a well-tolerated, minimally invasive procedure that can be used for the treatment of scars with a high level of patient satisfaction. Further clinical studies are needed to develop standardized treatment protocols.

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“…The effect and safety of recombinant human epidermal growth factor extracted from natural substances are basically the same as those secreted by human body, and there are no side effects. At the same time of improving the symptoms of sunken scar, it also has a certain impact on the quality of life of patients [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effect and Safety Analysis of PRP and Yifu Combined with Ultrapulsed CO2 Lattice Laser in Patients with Sunken Acne Scar

Wang

Wang²,

Zhang

et al. 2022

Journal of Healthcare Engineering

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Objective. To investigate the effect and safety of PRP and Yifu combined with ultrapulsed CO2 lattice laser in patients with sunken acne scar. Methods. 700 subjects were selected from the group of patients with sunken acne scar treated in our hospital from November 2010 to December 2020. They were divided into control group (n = 350) and study group (n = 350). The grouping was mainly based on the random number table method. Patients in the control group were treated with ultrapulse CO2 lattice laser, while those in the study group were treated with ultrapulse CO2 lattice laser combined with PRP and Yifu. The clinical effect, scar improvement and quality of life before and after treatment, and adverse events during treatment were compared between the two groups. The clinical effect was categorized into cure after treatment, significant effect, effective, and ineffective. The total effective rate = 1 − ineffective rate. Results. After treatment, the total effective rate of the study group (81.43%) was higher than that of the control group (70.00%). After treatment, ECCA, VSS scores, daily activities, symptoms and feelings, work and study, leisure and entertainment, interpersonal relationship, treatment status, and total scores were all lower in both groups than before treatment, and the study group was lower than the control group. During the treatment, the incidence of adverse events in the study group (17.33%) was lower than that in the control group (28.57%), P < 0.05 . Conclusion. PRP and Yifu combined with ultrapulse CO2 lattice laser in the treatment of sunken acne scar can effectively improve the scar, reduce the incidence of adverse events, and the treatment effect is obvious, which can improve the quality of life of the patients.

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Clinical and histopathological comparison of microneedling combined with platelets rich plasma versus fractional erbium-doped yttrium aluminum garnet (Er: YAG) laser 2940 nm in treatment of atrophic post traumatic scar: a randomized controlled study

Cited by 12 publications

References 19 publications

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Microneedling for the Treatment of Scars: An Update for Clinicians

Effect and Safety Analysis of PRP and Yifu Combined with Ultrapulsed CO2 Lattice Laser in Patients with Sunken Acne Scar

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