Clinical and immunological features in acute  respiratory-viral infections in children   with bronchial asthma

Мельникова, И. Ю.; Buryak, Vladimir N.; Dudko, Mariia V.; Мельник, С И; Batrachenko, Nina V.; No, Saint Petersburg Children's City Polyclinic

doi:10.26442/26586630.2020.1.190691

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“…The reduction of CD3+-cells in the acute infectious infl ammation occurs through a pathogen's action and may indicate immunoreactivity, which is fi rst provided by subpopulations of T-lymphocytes. During the immunologic response and with increased production of cytotoxic cells at the disease heat, the number of CD8+-lymphocytes increase [15].…”

Section: Discussionmentioning

confidence: 99%

State of Immunity in Preschoolers With Acute Respiratory Viral Infections Associated With Adenoid Vegetations

Dmitrova¹,

Smiyan

Holubnycha

et al. 2021

PSSS MS

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Introduction. Acute respiratory infections are the most common infectious diseases worldwide among children of different age groups. Materials and methods. 59 children between the ages of 3 and 7 participated in the study. The first group included 22 patients with an acute respiratory viral infection, the second one consisted of 23 patients with acute respiratory viral infections associated with adenoid vegetation, and 14 apparently healthy children were included in the control group. Immunology research was conducted during the acute period of the disease. Statistical processing of received data was done with the standard statistical software EZR 1.41. Results. After the research, most of the patients with acute respiratory viral infections were identified an actual increase in CD3+, CD4+, CD8+, CD22+- cells and IgA, IgM in the blood serum. Simultaneously, in patients with acute respiratory viral infections associated with adenoid vegetation during the acute period, the increase in total lymphocytes was identified due to CD4+, CD8+, CD22+ cells and IgG. A comparative analysis of the study results of both groups of patients showed that children from the second group had a significantly higher level of CD3+- cells, while the CD22+- lymphocytes, IgA, IgM and IgG were significantly lower from the similar indicators of the first group. Conclusions. The acute period of the disease in children with acute respiratory viral infections, associated with adenoid vegetation, had an imbalance in both the cell and the immune system's humoral component

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Section: Discussionmentioning

confidence: 99%