Clinical and immunological parallels in pregnancy loss

Mamedaliyeva, Nagima; Kurmanova, Almagul; Локшин, В. Н.; Kurmanova, Gaukhar; Issenova, Saule

doi:10.1080/09513590.2017.1404238

Cited by 7 publications

(8 citation statements)

References 5 publications

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“…A higher endometrial CD4/CD8 ratio, elevated CD4 levels and lower CD8 have all been reported in women with implantation failure when compared to controls [38]. Reduced CD8 levels have also been reported in recurrent pregnancy loss [39]. Examining concentrations in this study has shown that CD4 and CD8 counts are significantly lower in implantation failure perhaps supporting a role, either directly or indirectly, for these cells in this complex process.…”

Section: Discussionsupporting

confidence: 68%

Endometrial lymphocyte concentrations in adverse reproductive outcome populations

Marron¹,

Harrity

2019

J Assist Reprod Genet

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Purpose The uterine immunophenotype is relatively poorly understood, with most studies reporting proportions/percentages. A novel technique to calculate local endometrial lymphocyte concentrations is described, and used to compare results between aetiological subgroups such as repeated implantation failure (RIF) and recurrent pregnancy loss (RPL) with male-factor controls. Methods 455 patients had an endometrial biopsy performed. Background history on initial presentation was used to subdivide the population into RIF (n = 149), RPL (n = 121), primary (n = 76) and secondary infertility (n = 80). A control group was identified comprising male factor infertility aetiology with all female investigations normal (n = 29). Endometrial Tissue was assessed using a comprehensive multi-parameter panel. Lymphocyte subpopulations were calculated using flowcount flurospheres and a mathematical correction applied to determine concentrations per milligram of tissue, based on original biopsy weight and volumetric dilutions. Results The flow cytometry technique was successful in determining population centiles for concentrations of endometrial lymphocyte subsets. Distinct differences were noted across the patient groups. Th2 concentrations were significantly higher in the controls (p = 0.0002). All RPL/infertile populations had increased concentrations of peripheral type NK's (p = 0.016) and B cells (p = 0.045). Relative to male factor controls, CD4+ and CD8+ T lymphocyte populations were increased in RPL patients, and reduced in those with a history of RIF. Th1 concentrations were elevated in the adverse outcome groups (p = 0.032). Concentration centiles alone do not appear to accurately predict outcome with subsequent treatment. Conclusions Endometrial biopsy analysis by flow cytometry can provide detailed analysis of constituent lymphocyte subsets by concentration as well as proportion. This novel approach provides additional independent data to further assess the significance of endometrial changes in the setting of reproductive failure.

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Section: Discussionsupporting

confidence: 68%

Endometrial lymphocyte concentrations in adverse reproductive outcome populations

Marron¹,

Harrity

2019

J Assist Reprod Genet

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“…[31] In Kazakhstan, the rate of preterm birth remains at the level of 6.4% [32][33][34] according to official data and reports of domestic authors, and according to the WHO it is 8.8 cases per 100 births. [35] Urinary tract infections, which are also one of the causes of cerebral palsy, also remain at the same level [33,34,36], they are also often the cause of premature birth, which in combination can give an increased risk of developing cerebral palsy in the fetus / child [26][27][28], especially noted pyelonephritis [29], which in our work reliably showed a connection in the development of cerebral palsy.…”

Section: Discussionsupporting

confidence: 56%

Analysis of the Causes of Cerebral Palsy in Kazakhstan

Issenova¹,

Мамедалиева²,

Bodykov³

et al. 2021

Preprint

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Introduction: Cerebral palsy is the most common childhood disability Aims: Analyze and determine the main risk factors for the development of cerebral palsy in the population of Kazakhstan Materials and methods: Retrospective, analytical "case" - "control". Core group "case" - medical records of 100 pregnant women whose children at different ages has been diagnosed with cere-bral palsy Results: Thus, a retrospective analysis revealed the following features and complications in the perinatal period, which could promote the formation of cerebral palsy in children. Analytical results of the study are set significant results in cerebral palsy development Conclusion: Premature birth and urinary tract infections turned out to be the largest contribu-tors to the development of cerebral palsy, however, according to statistics, the rate of preterm birth, as well as the detection of infections, stably remains at the same level, while the number of cerebral palsy has been steadily growing since the early 1990s in Kazakhstan.

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“…It should be borne in mind that numerous medications can affect spermatogenesis, which makes their use preferable from the perspective of male infertility treatment. At the same time, endocrine disorders rarely directly lead to infertility [17,[29][30][31] .…”

Section: Discussionmentioning

confidence: 99%

Study of the influence of the biochemical composition of the human native ejaculate on the preservation of the male gametes’ activity after the application of cryopreservation technology

Begaidarova,

Baikoshkarova,

Mutaliyeva

2023

Reproductive and Developmental Medicine

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Objective The purpose of this study is to investigate the influence of the biochemical composition of human native ejaculate on the preservation of male gamete activity after the application of cryopreservation technology, and to evaluate the potential practical application of these findings in future fertilization processes. Methods The methodology employed in this study involves a systematic analysis of the technological aspects of cryopreserving human semen, coupled with an analytical examination of how the biochemical composition of semen affects the preservation of male gamete activity. Results The results of the study demonstrate a clear relationship between the activity of male gametes and changes in the biochemical composition of semen following cryopreservation. Conclusion This study addresses the issue of male infertility in Kazakhstan and underscores the importance of research in embryology and reproductive medicine to effectively address this problem.

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Clinical and immunological parallels in pregnancy loss

Cited by 7 publications

References 5 publications

Endometrial lymphocyte concentrations in adverse reproductive outcome populations

Endometrial lymphocyte concentrations in adverse reproductive outcome populations

Analysis of the Causes of Cerebral Palsy in Kazakhstan

Study of the influence of the biochemical composition of the human native ejaculate on the preservation of the male gametes’ activity after the application of cryopreservation technology

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