Clinical and laboratorial study of HPV infection in men infected with HIV

Figliuolo, Giuseppe; Maia, Jusimara; Jalkh, Alex Panizza; Miranda, Angélica Espinosa; Ferreira, Luíz Carlos Lima

doi:10.1590/s1677-55382012000300015

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…Thus, several studies have found an increased prevalence of HPV in individuals who are also HIV-infected17. Likewise, HIV infection can influence the natural history of HPV, by increasing the likelihood of a persistent infection and achieving greater virulence15.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection in oral fluids of HIV-1-positive men:prevalence and risk factors

Gaester

Fonseca

Luiz

et al. 2014

Sci Rep

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Human papillomavirus is one of the most common sexually transmitted diseases worldwide. The natural history of oral HPV infection is unclear, and its risk factors have not been explored. Immunocompromised individuals, as exemplified by HIV patients, are at high risk for HPV-related diseases. The mean of this study is to determine the prevalence ofHPV in the oral tract of HIV-1-positive male subjects and its association with risk factors. A total of 283 oral wash samples from HIV-1-positive men were tested. The oral fluid samples were used for DNA extraction and conventional PCR amplification; HPV genotyping was performed by hybridization. HPV genotyping revealed that nine samples (3.5%) were positive for HPV DNA; the major high-risk HPV types identified were 51 and 66. Worldwide studies have shown a variable prevalence of oral HPV. The diversity of genotypes and the high prevalence of multiple infections in HIV-infected subjects can be better explained by the effects of HIV-induced immunosuppression. The most important risk factors are unprotected sexual intercourse, but other factors for this infection have been described elsewhere including smoking, age and HIV-positive serostatus. In this study, smoking was the most important risk factor for acquiring oral HPV in HIV-1-infected subjects in Brazil.

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Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection in oral fluids of HIV-1-positive men:prevalence and risk factors

Gaester

Fonseca

Luiz

et al. 2014

Sci Rep

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“…In Brazil, Figliuolo et al . [ 15 ] observed high rates of HPV in HIV positive male heterosexual population, probably due to the high rate of female infection in our population, demonstrated in study done by Côrrea et al . [ 16 ] conducted in Manaus, State of Amazonas, Brazil.…”

Section: Discussionmentioning

confidence: 52%

Prevalence of Anogenital Warts in Men with HIV/AIDS and Associated Factors

Camargo¹,

Tasca²,

Mendes³

et al. 2014

TOAIDJ

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Background: Infection with human papilloma virus (HPV) is the most common sexually transmitted disease in the world. Among the 630 million new cases of HPV that occur each year, 30 million develop anogenital warts. Although subclinical infection with HPV is the most common cause, genital warts are also associated with immunosuppression caused by HIV. In view of the high prevalence of HPV/HIV co-infection particularly among men who have sex with men, the objectives of this study were to determine the prevalence of anogenital warts in men with HIV/AIDS and to identify associated factors.Methods: A cross-sectional study was conducted on 159 men with HIV/AIDS consecutively selected at a referral service in Botucatu, São Paulo, Brazil, in which the association between sociodemographic, behavioral and clinical variables and the presence of anogenital warts was evaluated. After hierarchical analysis of the data, variables presenting a p value ≤ 0.2 were entered into an unconditional multivariate logistic regression model.Results: Forty-nine (31%) of the HIV-positive patients had anogenital warts. The mean age was 44.6 ± 9.6 years. The main factors associated with the presence of anogenital warts were irregular antiretroviral treatment and genital herpes(HSV).Conclusion: The present study demonstrate that anogenital warts occur in almost one-third of the male population infected with HIV and factors associated with a higher risk of being diagnosed with anogenital warts were irregular cART use and co-infection with HSV, other variables could not be associated.

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“…In women with immunodeficiency, iatrogenic or acquired, the prevalence of HPV-associated lesions is higher than in immunocompetent individuals [9] . HIV-seropositive subjects experience an increased infection rate with a high number of relapse after treatment and an accelerated development of HPV-associated cancer [10] , [11] . In HIV-infected men, the prevalence of HPV in the genital area is 18.2% while that in the anus is 59.3% [12] , [13] .…”

Section: Introductionmentioning

confidence: 99%

High specific immune response to a bivalent anti-HPV vaccine in HIV-1-infected men in São Paulo, Brazil

Fontes

Andreoli

Villa

et al. 2016

Papillomavirus Research

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IntroductionInfection with Human papillomavirus (HPV) has been reported as one of the most prevalent agent sexually transmitted diseases, but its true prevalence in men is not precisely known, mainly due to the near absence of symptoms. Moreover, few studies evaluating the post-vaccination immune response have been performed to date in men, hence the hypotheses tested in this study can be important to enable a better understanding of both the immunopathogenesis and the response to vaccination in HIV-infected patients, and to help in the elaboration of strategies of vaccination against HPV in the HIV-infected population.ObjectivesTo analyze the specific response to antigens of HPV vaccine in HIV-infected men.MethodsA total of 25 HIV-infected male patients who met the inclusion criteria during the data collection period were vaccinated; however, six (30%) had anti-HPV at baseline, and were not considered further in the analysis. Therefore, 19 HIV-infected individuals were included in the study, along with five healthy, HPV-seronegative controls.ResultsPatients infected with HIV-1 were subdivided into two groups, A and B, according to their T CD4 cells count at the time of vaccination, namely: Group A: CD4>500; Group B: CD4<500. The proportion of seroconversion after immunization with three doses of a bivalent anti-HPV vaccine was 92%.ConclusionHIV-infected patients as well as HIV negative controls responded to anti-HPV vaccination, regardless of their T CD4 cells count and HIV plasma viral load. These results demonstrate that anti-HPV immunization in HIV-infected males is effective and should be encouraged, thus helping to decrease the risk of infection, mortality and morbidity of diseases associated with HPV in men.

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Clinical and laboratorial study of HPV infection in men infected with HIV

Abstract: ARTIcLe InfO ___________________________________________ _

Cited by 8 publications

References 7 publications

Human papillomavirus infection in oral fluids of HIV-1-positive men:prevalence and risk factors

Human papillomavirus infection in oral fluids of HIV-1-positive men:prevalence and risk factors

Prevalence of Anogenital Warts in Men with HIV/AIDS and Associated Factors

High specific immune response to a bivalent anti-HPV vaccine in HIV-1-infected men in São Paulo, Brazil

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Clinical and laboratorial study of HPV infection in men infected with HIV

Abstract: ARTIcLe InfO _______________________________________________________________ _____________________

Cited by 8 publications

References 7 publications

Human papillomavirus infection in oral fluids of HIV-1-positive men:prevalence and risk factors

Human papillomavirus infection in oral fluids of HIV-1-positive men:prevalence and risk factors

Prevalence of Anogenital Warts in Men with HIV/AIDS and Associated Factors

High specific immune response to a bivalent anti-HPV vaccine in HIV-1-infected men in São Paulo, Brazil

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Abstract: ARTIcLe InfO ___________________________________________ _