Human papillomavirus infection in oral fluids of HIV-1-positive men:prevalence and risk factors

Gaester, Karen; Fonseca, Luís; Luiz, Olinda do Carmo; Assone, Tatiane; Fontes, Adriele Souza; Costa, Fernando Ferreira; Duarte, Alberto J. S.; Casseb, Jorge

doi:10.1038/srep06592

Cited by 21 publications

(29 citation statements)

References 31 publications

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“…Our findings also support the previously reported association between oral HPV and HIV‐positive smokers . Some authors have observed odd ratios (from 2.8 5 to 10 14 ) for HPV infection in HIV smokers.…”

Section: Discussionsupporting

confidence: 93%

“…Among individuals with HIV, varying percentages of HR‐HPV sequences, from 3.5% to 24.8%, have been reported, the latter of which is similar to the 26.8% observed in this prospective study. Interestingly, the cohort studied by Mooij et al shares some characteristics with that of our study, such as MSM being the predominant transmission category.…”

Section: Discussionsupporting

confidence: 85%

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Type‐specific persistence and clearance rates of HPV genotypes in the oral and oropharyngeal mucosa in an HIV/AIDS cohort

Castillejos-García

Ramírez‐Amador

Carrillo-García

et al. 2018

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 85%

Type‐specific persistence and clearance rates of HPV genotypes in the oral and oropharyngeal mucosa in an HIV/AIDS cohort

Castillejos-García

Ramírez‐Amador

Carrillo-García

et al. 2018

J Oral Pathology Medicine

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“…HPV‐16 was the most prevalent high‐risk HPV in both study groups (together with HPV‐18 in HIV‐infected subjects). HPV‐16 has been described as the most common high‐risk type in oral infections in other studies conducted on similar populations, although other high‐risk HPVs emerged as more frequent in other investigations …”

Section: Discussionmentioning

confidence: 99%

Oral testing for high‐risk human papillomavirus DNA and E6/E7 messenger RNA in healthy individuals at risk for oral infection

Rollo¹,

Pichi²,

Benevolo³

et al. 2019

Cancer

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Background Testing for oral high‐risk human papillomavirus (HPV) DNA may be useful for identifying individuals at increased risk for HPV‐driven oropharyngeal cancer (OPC). However, positivity for HPV DNA provides no information on the transforming potential of the infection. In contrast, the detection of high‐risk HPV E6/E7 messenger RNA (mRNA) may help to identify clinically significant infections because of the indispensable role of E6/E7 viral oncoproteins in the carcinogenic process. Methods Oral rinses were collected with a mouthwash from cancer‐free individuals at increased risk for oral HPV infection. High‐risk HPV DNA and mRNA were evaluated via the testing of the oral rinses with the Linear Array HPV genotyping test and the Aptima HPV assay, respectively. Results Overall, 310 subjects with no clinical evidence of lesions of the oral cavity and oropharynx were included in the study. Thirty‐three (10.6%) harbored high‐risk HPV DNA in their oral rinse. These cases, together with 10 random samples negative for high‐risk HPV DNA, were tested with the Aptima assay. A valid result was obtained for 41 of the 43 specimens (95.3%). Among the 31 cases that were positive for high‐risk HPV DNA and had a valid Aptima result, 4 (12.9%) were positive for HPV mRNA. HPV mRNA was not detected in any of the samples negative for high‐risk HPV DNA. Conclusions HPV mRNA is detectable in oral rinses of cancer‐free subjects. Oral HPV mRNA testing may be useful in the screening and/or early detection of HPV‐driven OPC by possibly identifying active and transforming oral infections. The testing of individuals at increased risk for HPV‐related OPC via simply and noninvasively collected oral specimens is an attractive option for future screening strategies.

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“…Going into the study we expected that the HIV-positive cohort might be much more susceptible to HPV-induced head and neck cancers and the proportion of HPV-positive tumors would be much higher in the HIV-infected group. This was based on studies demonstrating the higher prevalence and persistence of oral HPV infection in HIV-positive groups compared with a healthy population (12, 13). Furthermore, it was expected that the HIV infected individuals with head and neck cancer would have poorer outcome due to immunosuppression from their underlying HIV infection and associated health risks, including higher rates of smoking, intravenous drug use, complications of AIDS and susceptibility to other infections and inflammation(2, 14–16).…”

Section: Discussionmentioning

confidence: 99%

High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV

Walline

Carey

Goudsmit

et al. 2017

Molecular Cancer Research

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In this study, high-risk HPV (hrHPV) incidence, prognostic biomarkers, and outcome were assessed in HIV-positive (case) and HIV-negative (control) patients with head and neck squamous cell cancer (HNSCC). HIV-positive cases were matched to controls by tumor site, sex, and age at cancer diagnosis. A tissue microarray (TMA) was constructed and DNA isolated from tumor tissue. MultiPlex-PCR MassArray, L1-PCR and In Situ Hybridization were used to assess hrHPV. TMA sections were stained for p16ink4a, TP53, RB, CCND1, EGFR, and scored for intensity and proportion of positive tumor cells. The HNSCC cohort included 41 HIV-positive cases and 41 HIV-negative controls. Tumors from 11/40 (28%) cases, and 10/41 (24%) controls contained hrHPV. p16 expression, indicative of E7 oncogene activity, was present in 10/11 HPV-positive cases and 7/10 HPV-positive controls. Low p16 and high TP53 expression in some HPV-positive tumors suggested HPV-independent tumorigenesis. Survival did not differ in cases and controls. RB expression was significantly associated with poor survival (p=0.01). High TP53 expression exhibited a trend for poorer survival (p=0.12), but among cases, association with poor survival reached statistical significance (p=0.04). The proportion of HPV-positive tumors was similar, but the heterogeneity of HPV types was higher in the HIV-positive cases than in HIV-negative controls. High RB expression predicted poor survival, and high TP53 expression was associated with poorer survival in the HIV-positive cases but not HIV-negative controls. Implications HIV infection did not increase risk of death from HNSCC, and HPV-positive tumors continued to be associated with a significantly improved survival, independent of HIV status.

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Human papillomavirus infection in oral fluids of HIV-1-positive men:prevalence and risk factors

Cited by 21 publications

References 31 publications

Type‐specific persistence and clearance rates of HPV genotypes in the oral and oropharyngeal mucosa in an HIV/AIDS cohort

Type‐specific persistence and clearance rates of HPV genotypes in the oral and oropharyngeal mucosa in an HIV/AIDS cohort

Oral testing for high‐risk human papillomavirus DNA and E6/E7 messenger RNA in healthy individuals at risk for oral infection

High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV

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