Clinical and metabolic profile and its relationship with insulin resistance among school children

Abstract

Objective: to investigate the clinical and metabolic profile and its relationship with insulin resistance among school children. Methods: a cross-sectional study of 186 adolescents aged 10 to 19 years old. Clinical variables were: body mass index, waist circumference, and neck, conicity index, systolic, diastolic and mean blood pressure; and metabolic variables were: triglycerides, glucose, total cholesterol, high-density lipoprotein and low-density lipoprotein cholesterol, insulin and Homeostasis Model Assessment index. It was considered statistically significant at p<0.05. Results: there was a prevalence of females, with 19.4% and 6.5% of overweight and obesity, respectively. The prevalence of insulin resistance was 42.5%. Distribution of clinical and metabolic variables of adolescents according to quartiles of the Homeostasis Model Assessment index blood pressure, blood glucose, and insulin increased the values of the Homeostasis Model Assessment index increased. Conclusion: insulin resistance is present in adolescents, and this condition is associated with the clinical and metabolic changes. Descriptors: Insulin Resistance; Adolescent; Health Profile. Objetivo: investigar o perfil clínico e metabólico e sua relação com resistência à insulina entre escolares. Métodos: estudo transversal realizado com 186 adolescentes de 10 a 19 anos. Foram consideradas variáveis clínicas: índice de massa corporal, circunferência da cintura e do pescoço, índice de conicidade, pressão arterial sistólica, diastólica e média; variáveis metabólicas: triglicerídeos, glicemia, colesterol total, high-density lipoprotein e low-density lipoprotein colesterol, insulina e índice Homeostasis Model Assessment. Considerouse significância estatística p<0,05. Resultados: observou-se prevalência do sexo feminino, com 19,4% e 6,5% de excesso de peso e obesidade, respectivamente. A prevalência de resistência à insulina foi de 42,5%. Na distribuição das variáveis clínicas e metabólicas dos adolescentes segundo os quartis do índice Homeostasis Model Assessment pressão arterial sistêmica, glicemia e insulina aumentaram à medida que os valores do índice Homeostasis Model Assessment elevavam. Conclusão: resistência insulínica está presente em adolescentes e esta condição associa-se às alterações clínicas e metabólicas.

Alterações clínicas, metabólicas e resistência à insulina entre adolescentes

“…It was presented with altered levels in 28% of the research subjects, and it is considered one of the complications of obesity. This result is similar to the data collected in a study carried out with 186 adolescents aged 10 to 19 years old, which observed IR predominance in 42.5% of research participants; (5) and to the research carried out with 121 obese children and adolescents, aged 6 to 17 years old, in Coimbra, Portugal, which observed the presence of IR in 38.1% of them, using HOMA-IR with 3 as a cutoff point; in that same study, 12.5% of individuals had some form of dyslipidemia. (3) Moreover, higher frequencies were found in a research with 321 obese adolescents aged 10 to 17 years old, with 65% of assessed subjects presenting IR.…”

“…(21) Despite its causes being preventable, excessive weight has been growing worse in this age gap, thus becoming the health issue in largest evolution worldwide. (5) Prevalence observed in literature suff ers slight diff erences when compared to the data presented in this study. Th ey vary between minimum values at 11.2% to maximum at 38% of overweight children and adolescents.…”

“…(4) Other studies that were carried out with the same research public reinforced the assertion that dyslipidemic adolescents present higher IR levels when compared to eutrophic ones. (5)(6)(7) Given the aforementioned facts, identification of IR in adolescents using HOMA-IR index, with additional assessment of anthropometric and metabolic variables of this population group, makes it possible to identify the risk factors that are more closely associated to IR development and of its sec-ondary diseases, thus assisting on the implementation of intervention measures scoped on public health prevention of cardiovascular events and non-transmittable chronic diseases in adolescence and adulthood. (3,6) Therefore, a necessity for further clarification is observed when it comes to detection of IR in adolescents.…”

Padrão alimentar e resistência à insulina em adolescentes

“…A RI é desencadeadora da síndrome metabólica (SM), estando associada à obesidade, pré-diabetes, diabetes mellitus tipo 2 e vários outros fatores de risco cardiometabólico (Nogueira-de-Almeida & Mello, 2018;Kostovski, et al, 2018;Bielemann, et al, 2015). As taxas de prevalência de RI variam de 5,5% a 72,3% em adolescentes, dependendo do método utilizado (Vikram, 2017;Leal, et al, 2016). Dessa forma, a identificação precoce da RI nesse Research, Society and Development, v. 9, n. 12, e29291210786, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i12.10786 público é relevante sob o ponto de vista da saúde pública (Park, Lee & Lee, 2017).…”