Clinical and morphological features of age-related, posttraumatic and metabolic phenotypes of late stage knee osteoarthritis

Abstract

Participants were asked to wear their Fitbit TM daily during waking hours (removing for water-based activities), and sync the device at least every three days during the study period of 90 days. We downloaded step count data from each participant's Fitbit TM using the product interface (www. fitbit.com). For each day of the 90-day period, a minimum of 1500 steps was needed to be recorded by the device for that day to be considered a valid day. Average daily step count was presented as mean (±SD). Participants were classified as physically inactive (5000-7499 steps/day), moderately active (7500-9999 steps/day), physical active (10,000 steps/day), and very active (12,500 steps/day) (Tudor-Locke & Basset, Sports Med, 2004). The associations between step count and health-and knee-related quality of life were evaluated with Pearson correlation coefficients (r). Results: Thirty-two participants with PF OA were included (Table 1). Participants reported moderate to severe knee-related symptoms, with the greatest limitations reported on the pain and function in activities of daily living subscales of KOOS. The mean (±SD) daily step count was 9660±3455 (range 5148 to 17380), and the average number of valid days was 87±6 (range, 67 to 90). 34% of participants were classified as physically inactive, 25% were moderately active, 22% were physically active, and Values represent median (range). g¼grams, IU¼international units, kcal¼kilocalories, mg¼milligrams, n¼number of participants, mg¼micrograms Abstracts / Osteoarthritis and Cartilage 28 (2020) S86eS527 S391

Gonartrozlu Hastalarda Trigliserit Glikoz İndeksi ile Nötrofil Lenfosit Oranı Arasındaki İlişki

“…3 Metabolic conditions play a signi cant role in the development and progression of this disease, such as adipokines, high blood sugar, hormonal changes, and free radicals, which lead to the development of this complication in middle age (45-65 years old) and brings pain and disability. 4 While the prevalence rate of metabolic syndrome for people without osteoarthritis is about 23%, studies show that this prevalence rate for osteoarthritis patients is 59%. 5 e ndings of studies also show a relationship between having metabolic syndrome and developing arthritis at a younger age, and these patients usually have more pain and general symptoms than patients without metabolic syndrome.…”

“…5 e ndings of studies also show a relationship between having metabolic syndrome and developing arthritis at a younger age, and these patients usually have more pain and general symptoms than patients without metabolic syndrome. 2,4,5 Today, gonarthrosis is a systemic and inhomogeneous disease, and its structural and clinical aspects have been greatly improved over the past years, improving our understanding of its pathology. Age-related, metabolic, genetic, and pain-related phenotypes are hypothesized for this disease.…”