Aim: This study investigated the relationship between Triglyceride Glucose, Neutrophil Lymphocyte Ratio, and gonarthrosis disease to investigate the role of these indicators in developing gonarthrosis. Method: Our study retrospectively investigated 141 patients aged between 50-84 years old who underwent follow-up in our orthopedic clinic between 01.06.2022-01.10.2021. The participants were divided into two control and study groups. Participants diagnosed with gonarthrosis were included in the study group, and healthy controls were included in the control group. Demographic characteristics of the patients and biochemical data were collected from patient files and electronic records. Results: The age of the patients was 54±12.5 (18-75) years. Among the biochemical parameters in our study, in cases with fasting gallstones, plasma glucose is 124.6 ± 24.5 mg/dL, triglyceride 198.3 ± 36.8 mg/dL, insulin 16.5 ± 5.6 uIU/mL, HOMA-IR 4 The level of .8±1.2 was statistically significantly higher in all of them compared to the control group (p=0.001). TGYI shows a significant difference according to the group (p

Objective: The prevalence of thyroid dysfunction is higher in patients with diabetes, and its diagnosis could cause better diabetes management. The purpose of the present study is to examine the impact of pathophysiological changes in patients with Type-2 diabetes on the frequency of thyroid dysfunction, thyroid autoimmunity, thyroid nodule, and thyroid cancer in Turkey. Methods: The study was conducted on a total of 3.276 patients with Type-2 diabetes who underwent thyroid tests and thyroid ultrasonography (US). The demographic characteristics, biochemical and hormonal values, thyroid US reports, and histopathology reports were collected from the patient's electronic records. Results: Thyroid autoimmunity positive TPOab 15.9% (n = 524) and/or positive TGab 9.9% (n = 327), the rate of positivity of both antibodies (TPOab + TGab) in the same patient, and total thyroid autoimmunity was found to be 32.57% (n=1067) in Type-2 diabetic patients. Thyroid dysfunction was detected in 18.3% (n = 602) of these patients. The distribution of thyroid dysfunction was 9.09% (n = 298) subclinical hypothyroidism, 4.1% (n = 135) clinical hypothyroidism, 3.1% (n = 102) subclinical hyperthyroidism, 2.0% (n = 67) clinical hyperthyroidism. Also, 67.9% (n = 2225) thyroid nodules, and 5% (n = 164) thyroid cancer were detected. Conclusion: Thyroid dysfunction was found to have increased in patients with Type-2 diabetes at significant levels.