Clinical and Pathologic Features of Patients with Rare Ovarian Tumors: Multi-Center Review of 167 Patients by the Anatolian Society of Medical Oncology

Malignant ovarian germ cell tumors (MOGCT) are rare neoplasms that most frequently occur in women at a young reproductive age. There have been limited data regarding this disease from Southeast Asian countries. We therefore conducted a retrospective study to analyze the clinical characteristics and the treatment outcomes of MOGCT treated at our institute between January, 2003 and December, 2012. Seventy-six patients were recruited from this period with the mean age of 21.6 years and 11.8% were pre-puberty. The two most common symptoms were pelvic mass and pelvic pain. Two-thirds of the studied patients presented at an early stage. The most common histology was immature teratoma (34.2%) followed by endodermal sinus tumor (28.9%), dysgerminoma (25%), mixed type (10.5%) and choriocarcinoma (1.3%). Over 80% of these patients received fertility sparing surgery and about 70% received adjuvant chemotherapy with the complete response rate at 73.3% and partial response at 11.1%. The most frequent chemotherapy was BEP regimen (bleomycin, etoposide, cisplatin). With the mean follow up time at 56.0 months, 12 patients (15.8%) developed recurrence and only an advanced stage was the independent prognostic factor. The ten year progression free survival (PFS) and overall survival rate of our study were 81.9% and 86.2%, respectively. In conclusion, MOGCT often occurs at a young age. Treatment with fertility sparing operations and adjuvant chemotherapy with a BEP regimen showed a good outcome. An advanced stage is a significant prognostic factor for recurrence.

Section: Discussionsupporting

confidence: 88%

“…The most common histology is dysgerminoma followed by immature teratoma and endodermal sinus tumor (EST) (Bilici et al, 2013;Vazquez and Rustin, 2013). Moreover, MOGCT is often found in a mixed type with the most common combination of dysgerminoma and EST (Parkinson et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Malignant Ovarian Germ-Cell Tumors Treated in Chiang Mai University Hospital over a Nine Year Period

Neeyalavira¹,

Suprasert²

2014

“…Polycystic ovary syndrome (PCOS) is a proliferative disorder among women of reproductive age, and currently considered a predominantly hyperandrogenic syndrome (Azziz et al, 2009;Bilici et al, 2013;, Haroon et al, 2014;Liu et al, 2013;Takiar et al, 2014a;2014b). The three main diagnostic guidelines are the 1990 National Institutes of Health (NIH) criteria (Dunaif, 1992) T2DM is a disease characterized by impaired insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of TCF7L2 Lack Influence on Risk of the Polycystic Ovary Syndrome - a Systemic Analysis

Lin

Yang²,

Ding³

et al. 2014

“…Ovarian germ cell malignancy mostly occurs in the second decades of life, accounting for 5% of ovarian malignancies, and is mainly unilateral, although 10-15% of dysgerminoma involve bilaterally (Gershenson, 2007;Bilici et al, 2014). Majority of this gynecologic malignancy has been very favorable outcomes, high chemosensitivity, and long-term survival.…”

Section: Introductionmentioning

confidence: 99%

8-year Analysis of the Prevalence of Lymph Nodes Metastasis, Oncologic and Pregnancy Outcomes in Apparent Early-Stage Malignant Ovarian Germ Cell Tumors

Chatchotikawong

Ruengkhachorn²,

Leelaphatanadit³

et al. 2015

At 26.1 months of median follow-up time (range 1.9-88.5 months), 9 patients retained fertility functions, with uneventful pregnancies in 3 of these. Only one patient (2.6%) had progression of disease at 4.9 months after surgery. The 5-year survival rate was 97.4%. Conclusion: As the rate of pelvic or para-aortic node metastasis in MOGCT is considerable, lymphadenectomy should be incorporated in surgical staging procedures.