Clinical and pathological factors associated with progression of diabetic nephropathy

Liang, Shuang; Cai, Guangyan; Chen, Xiangmei

doi:10.1111/nep.13182

Cited by 44 publications

(41 citation statements)

References 53 publications

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“…In the early stage, diabetic nephropathy presents as microalbuminuria. Previous studies have reported an association between IR and an increased risk of developing progressive diabetic nephropathy among patients with diabetes [34,35]. The Northern Shanghai Study [20] also found that a higher TyG index was associated with a higher risk of microalbuminuria and chronic kidney disease in elderly Chinese community-dwelling individuals.…”

Section: Discussionmentioning

confidence: 86%

Associations between Triglyceride-Glucose Index and Micro- and Macro-Angiopathies in Type 2 Diabetes Mellitus

et al. 2020

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The aim of this study was to investigate the associations between the triglyceride-glucose (TyG) index, a marker of insulin resistance, and microangiopathies and macroangiopathies in patients with type 2 diabetes mellitus (DM). Our study enrolled 1990 type 2 diabetic patients from local hospitals in Taiwan during the period of 2002–2004. Multivariate logistic regression analysis was used to identify the factors related to microangiopathies, macroangiopathiess and TyG index. The patients were stratified by TyG index quartile (Q1–Q4). Adjusted odds ratios (aORs) of albuminuria for Q3 versus Q1 and Q4 versus Q1 were 1.424 (95% confidence interval [CI], 1.062–1.910, p = 0.018) and 1.948 (95% CI, 1.437–2.642, p < 0.001), respectively. The aOR of cerebrovascular disease (CVA) was 2.264 for Q4 versus Q1 (95% CI, 1.243–4.122, p = 0.008), but there were no significant associations with diabetic retinopathy (DR), coronary artery disease (CAD) or peripheral artery occlusive disease (PAOD). Significant stepwise increases were found in CVA (p = 0.0013) and albuminuria ≥30 mg/g (p < 0.001) corresponding to TyG index quartiles, but not DR (p = 0.573), CAD (p = 0.880) or PAOD (p = 0.223). There was a significant association between a high TyG index and a high risk of microalbuminuria and CVA in the study cohort. Further studies to investigate the use of medications in patients with DM to prevent micro- and macro-angiopathies are thus warranted.

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Section: Discussionmentioning

confidence: 86%

Associations between Triglyceride-Glucose Index and Micro- and Macro-Angiopathies in Type 2 Diabetes Mellitus

et al. 2020

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“…However, in DM patients, the risk of cardiovascular complications is equivalent to that of patients with CAD, and, thus, similar treatment methods should be adopted to improve the prognosis of cardiovascular diseases ( 11 , 12 ). DM is usually accompanied with hypertension, which is a key risk factor for cardiovascular complications in DM patients ( 13 , 14 ). Previous studies reported that approximately 20–60% of DM patients were also suffering hypertension, and 25–50% of hypertension patients were combined with DM, and patients with DM and hypertension were usually more susceptible to the cardiovascular diseases ( 15 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation between the levels of serum cystatin�C and substance�P in peripheral blood in diabetes mellitus patients complicated with hypertension

Zhu

Gong²,

Luo

et al. 2018

Exp Ther Med

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Correlation between the serum cystatin C and substance P in peripheral blood of diabetes mellitus patients complicated with hypertension was investigated. Diabetes mellitus patients with or without hypertension were selected in No. 215 Hospital of Shaanxi Nuclear Industry from December 2015 to February 2017. There were 60 patients with only hypertension (hypertension control group), 60 patients with only diabetes mellitus (diabetes mellitus control group) and 60 patients with diabetes mellitus combined with hypertension (observation group). Levels of serum cystatin C and substance P in peripheral blood were measured via immunoturbidimetry and enzyme-linked immunosorbent assay, respectively, and the correlation with hypertension was analyzed. The average level of serum cystatin C in the observation group was higher than that of the two control groups (P<0.05). The level of substance P in peripheral blood of the observation group was lower than that of the diabetic control group (P<0.05). The levels of serum cystatin C in patients with grade III hypertension in observation group were higher than those in grades II and I, and the levels of substance P in peripheral blood of patients with grade III hypertension in observation group were lower than those in grades II and I. Systolic pressure of patients in observation group was significantly positively correlated with level of serum cystatin C, but significantly negatively correlated with level of substance P in peripheral blood (P<0.05). Compared with the diabetes mellitus patients, level of serum cystatin C was higher, and level of substance P peripheral blood was lower in diabetes mellitus patients complicated with hypertension. In diabetes mellitus patients, blood pressure was positively correlated with serum cystatin C level, and negatively correlated with substance P level in peripheral blood.

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“…Ipak, iako razlika u trajanju dijabetesa između bolesnika sa i bez DN nije bila značajna, ono je prosječno bilo za dvije godine duže kod bolesnika sa DN i upravo je trajanje dijabetesa izdvojeno kao faktor rizika za DN i za pogoršanje funkcije bubrega. I druge studije su pokazale da je duže trajanje dijabetesa značajan faktor rizika za nastanak DN i istakle značaj ranog otkrivanja dijabetesa [18,19]. Međutim, za rano otkrivanje dijabetesa neophodne su redovne kontrole bolesnika.…”

Section: Diskusijaunclassified

Diabetic nephropathy in type 2 diabetes: The frequency and risk factors

Kovačević

Mališ

Kovacevic

et al. 2019

Biomedicinska istraž.

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Uvod. Ciljevi rada su bili da se utvrdi učestalost i faktori rizika za dijabetesnunefropatiju (DN) kod bolesnika sa tipom 2 dijabetesa i faktori povezanisa pogoršanjem funkcije bubrega tokom trogodišnjeg perioda.Metode. Studija je obuhvatila 81 bolesnika sa tipom 2 dijabetesa kojisu na početku studije svrstani u dvije grupe: prva, 41 bolesnik sa DN (27muškaraca, 62,03 ± 7,73 godina) i druga, 40 bolesnika bez DN (17 muškogpola, 61,73 ± 11,55 godina). Svim bolesnicima je uzeta anamneza, urađenobjektivni pregled i laboratorijska ispitivanja. Na osnovu rezultata ispitivanja,poslije tri godine bolesnici obje grupe su podijeljeni u podgrupe sanepromjenjenom funkcijom bubrega i podgrupe sa pogoršanjem funkcijedefinisanim kao povećanje proteinurija i/ili smanjenje jačine glomerulskefiltracije (JGF) za više od 25%.Rezultati. Na početku ispitivanja zabilježena je visoka učestalost poznatihfaktora rizika za dijabetes i DN kod obje grupe. Multivarijantna logističkaanaliza izdvojila je ženski pol i trajanje dijabetesa kao značajne prediktoreDN. Nakon tri godine funkcija bubrega se pogoršala kod oko 50% bolesnikasa i bez DN, a u podgrupama sa pogoršanjem funkcije bubrega glikemijanašte i HbA1c su bili statistički značajno veći nego u podgrupama sastabilnom funkcijom bubrega. Linearna regresiona analiza je pokazala daje promjena JGF u trogodišnjem periodu značajno povezana sa starošćubolesnika, trajanjem dijabetesa, sistolnim krvnim pritiskom, razlikom u dijastolnomkrvnom pritisku i proteinuriji. Promjena u proteinuriji značajnoje povezana sa sistolnim krvnim pritiskom, razlikom u dijastolnom krvnompritisku, kao i HbA1c i JGF na kraju studije.Zaključak. Kod bolesnika sa tipom 2 dijabetesa ženski pol i duže trajanjedijabetesa izdvojeni su kao značajni faktori rizika za DN, a starost bolesnika,trajanje dijabetesa, povišen krvni pritisak, loša glikoregulacija kao faktoririzika za pogoršanje funkcije bubrega.

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Clinical and pathological factors associated with progression of diabetic nephropathy

Cited by 44 publications

References 53 publications

Associations between Triglyceride-Glucose Index and Micro- and Macro-Angiopathies in Type 2 Diabetes Mellitus

Associations between Triglyceride-Glucose Index and Micro- and Macro-Angiopathies in Type 2 Diabetes Mellitus

Correlation between the levels of serum cystatin�C and substance�P in peripheral blood in diabetes mellitus patients complicated with hypertension

Diabetic nephropathy in type 2 diabetes: The frequency and risk factors

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