Clinical and radiological evaluation of patients with lytic, mixed and sclerotic bone metastases from solid tumors: is there a correlation between clinical status of patients and type of bone metastases?

Abstract

Our results show a clear correlation between the type of bone metastases and the clinical status of patients. Patients with excessive bone resorption suffer the most, and may be given priority in treatment. CT proved to be a practical and efficient method to investigate and classify metastatic bone lesions.

Clinical and radiologic response in patients with bone metastases managed with combined radiotherapy and bisphosphonates

“…Evaluations with computed tomography revealed a 73% increase in bone density at metastatic bone lesions (measured in Hounsfield Units) [5]. Interestingly bone density was found to have a strong, negative and statistically significant correlation with pain (Rs ¼ À0.57) [5,7]. Similar results were reported in the second study, with patients with osteolytic lesions achieving a higher degree of clinical and radiologic response from baseline [6].…”

“…Taking into account the correlation between bone density and pain that is statistically significant, strong and negative (Rs ¼ À0.57), the marked reossification may be responsible for the improved clinical response noted in the above-mentioned studies [5][6][7]. After these encouraging results, the next step should be to carry out a randomized study to compare the effectiveness of radiotherapy with that of combined treatment.…”

Fluoroscopy-Guided Percutaneous Vertebral Body Biopsy Using a Novel Drill-Powered Device: Technical Case Series

“…There were no discordantly categorized cases. The mean attenuation of each lesion was also measured in Hounsfield units (HU) [9]. Normal bone lesion quality was defined as vertebral body marrow signal abnormality on MRI or focal 18 F-fluorodeoxyglucose uptake in the vertebral body marrow on PET with no CT correlate.…”

Bone mineral density in Japanese prostate cancer patients under androgen-deprivation therapy

“…Supporting this is that regions with osteoblastic bone metastasis show significantly higher bone density than regions with osteolytic bone lesions (Vassiliou et al 2007). These observations have led many BMD studies to exclude patients with bone metastasis.…”