Clinical and Rehabilitative Predictors of Peak Oxygen Uptake Following Cardiac Transplantation

Uithoven, Katelyn E.; Smith, Joshua R.; Medina‐Inojosa, José R.; Squires, Ray W.; Iterson, Erik H. Van; Olson, Thomas P.

doi:10.3390/jcm8010119

Cited by 12 publications

(8 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients completed an institutionally designed exercise protocol on a motor-driven treadmill (GE CASE, Milwaukee, Wisconsin, USA) consisting of increasing two metabolic equivalents every 2 min until volition fatigue. 16,23–25 The CPET was terminated if concerns of significant arrhythmias, electrocardiographic abnormalities and/or abnormal blood pressure responses occurred and these data were not used in analysis. All CPETs were performed using the same gas exchange metabolic systems (MGC Diagnostics, St Paul, Minnesota, USA).…”

Section: Methodsmentioning

confidence: 99%

Predictors of exercise capacity following septal myectomy in patients with hypertrophic cardiomyopathy

Smith

Layrisse

Medina‐Inojosa

et al. 2020

Eur J Prev Cardiolog

View full text Add to dashboard Cite

Aims Patients with hypertrophic obstructive cardiomyopathy (HOCM) have impaired exercise capacity. The gold standard therapy for patients with HOCM is septal myectomy surgery; however, changes in maximum oxygen uptake (VO2peak) following myectomy are variable, with VO2peak decreasing in some patients. Therefore, we evaluated changes in VO2peak following surgical myectomy to determine clinical predictors of those exhibiting decreased VO2peak post-myectomy. Methods HOCM patients ( N = 295) who performed symptom limited cardiopulmonary exercise testing prior to and following surgical myectomy were included for analysis. The VO2peak non-responder group ( n = 128) was defined as <0% change in VO2peak from pre- to post-myectomy. Step-wise regression models using demographics, clinical, and physiologic characteristics were created to determine predictors of hypertrophic cardiomyopathy patients in the VO2peak non-responder group. Results Independent predictors of the VO2peak non-responder group included higher pre-myectomy VO2peak (% predicted), older age, women, history of dyslipidemia, lack of cardiac rehabilitation enrollment, and lower body mass index (all p < 0.03). Forty-three (14.6%) patients reached the primary end-point of all-cause mortality during a median follow up of 11.25 years (interquartile range 6.94 to 16.40). After adjustment for age, sex, beta-blocker use, coronary artery disease history, and body mass index, the VO2peak non-responder group had greater risk of death compared with the VO2peak responder group (adjusted hazard ratio: 1.77, 95% confidence interval: 1.06–3.34, p = 0.01). Conclusion This large hypertrophic cardiomyopathy cohort demonstrated that demographic (i.e. female sex), lack of cardiac rehabilitation enrollment, and cardiovascular risk factors (i.e. history of dyslipidemia) are predictive of those patients that did not exhibit increases in VO2peak following septal myectomy surgery.

show abstract

Section: Methodsmentioning

confidence: 99%

Predictors of exercise capacity following septal myectomy in patients with hypertrophic cardiomyopathy

Smith

Layrisse

Medina‐Inojosa

et al. 2020

Eur J Prev Cardiolog

View full text Add to dashboard Cite

show abstract

“…Cardiopulmonary exercise testing (CPX) is a useful way to evaluate prognosis, risk of metabolic diseases, condition of diseases, determination of exercise intensity, and efficacy of exercise therapy [1][2][3][4][5] . The most popular marker is peak oxygen uptake (VO 2 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxygen uptake adjusted by skeletal muscle mass in cardiovascular disease patients with type 2 diabetes

et al. 2021

View full text Add to dashboard Cite

We aimed to evaluate oxygen uptake adjusted by total skeletal muscle mass in patients with cardiovascular disease with or without type 2 diabetes mellitus. [Participants and Methods] The participants included 54 males ≥50 years of age without heart failure who underwent cardiopulmonary exercise testing during cardiac rehabilitation. We divided the participants into two groups: patients with type 2 diabetes mellitus (DM group) and patients without type 2 diabetes mellitus (NDM group). [Results] We found no significant differences in age, weight, fat mass, or skeletal muscle mass between the groups. There were also no differences in cardiac function, body composition, and heart rate response. The DM group showed significantly lower peak oxygen uptake values adjusted by skeletal muscle mass, despite the absence of significant differences in skeletal muscle mass. A significant positive correlation was found between peak oxygen uptake and age, weight, and skeletal muscle mass. Stepwise regression analysis revealed that age, skeletal muscle mass, and medical history of diabetes were independent predictors of absolute peak oxygen uptake. [Conclusion] Peak oxygen uptake adjusted by skeletal muscle mass in patients with cardiovascular disease and type 2 diabetes mellitus is lower than that in those without type 2 diabetes mellitus.

show abstract

“…Многочисленные работы показывают улучшение физической работоспособности, пикового потребления кислорода и других параметров легочной вентиляции и газообмена в общей когорте пациентов, перенесших ТС [16][17][18][19]. Однако при анализе влияния длительной ишемии аллотрансплантата авторы, как правило, используют только основные характеристики клинических исходов, такие как реакции отторжения трансплантата, выживаемость [4][5][6]15].…”

Section: Discussionunclassified

Functional state of the cardiorespiratory system after orthotopic heart transplantation with prolonged cold ischemia time

Логинова

Каменская

Фомичев

et al. 2020

RJTAO

View full text Add to dashboard Cite

Objective: to assess the functional state of the cardiorespiratory system in the long term after orthotopic heart transplantation (HT) with prolonged cold ischemia time. Materials and methods. The results of 60 orthotopic HTs performed at Meshalkin National Medical Research Center were analyzed. A comparison was made of the immediate and long-term outcomes of HTs in the group with cold ischemia time lasting for less than 240 minutes and in those with farther distance between donor and recipient sites with cold ischemia time of 240 minutes or more. In the long-term follow-up after HT, all patients underwent cardiopulmonary exercise testing, body plethysmography, assessment of the diffusing capacity of the lungs, and quality of life assessment. Results. Prolonged cold ischemia showed a negative effect on the early postoperative period – decreased myocardial contractility on postoperative day 1 and longer duration of inotropic support. At the same time, the survival rate and incidence of graft rejection reactions in the early and late post-HT periods in the studied groups did not differ significantly. Peak oxygen consumption in the general group in the long term after HT was 17 (14.7–21.0) mL/kg/min, VE/ VCO2 slope was 30 (29–36) at 100 (90–120) W threshold load power. All the parameters of pulmonary function tests did not differ significantly depending on cold ischemia duration. Quality of life also did not show significant differences depending on the duration of graft ischemia in terms of both physical and psycho-emotional health components of the SF-36 questionnaire. Conclusion. Long-term cold ischemia of the graft did not show any negative impact on the functional state of the cardiorespiratory system and quality of life in the long term after HT. The studied group of recipients was characterized by high efficiency of pulmonary ventilation and gas exchange, as well as high tolerance to physical activity in the long-term post-HT period.

show abstract

Clinical and Rehabilitative Predictors of Peak Oxygen Uptake Following Cardiac Transplantation

Cited by 12 publications

References 42 publications

Predictors of exercise capacity following septal myectomy in patients with hypertrophic cardiomyopathy

Predictors of exercise capacity following septal myectomy in patients with hypertrophic cardiomyopathy

Evaluation of oxygen uptake adjusted by skeletal muscle mass in cardiovascular disease patients with type 2 diabetes

Functional state of the cardiorespiratory system after orthotopic heart transplantation with prolonged cold ischemia time

Contact Info

Product

Resources

About