Clinical application of chitin non-woven fabric as wound dressing

Ohshima, Yoshio; Nishino, Koichi; Yonekura, Y; Kishimoto, Satoko; Wakabayashi, Shunji

doi:10.1007/bf00578375

Cited by 59 publications

(28 citation statements)

References 8 publications

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“…Its advantages include its ability to decrease wound pain, suitable wound drying and good adherence to the wound bed. Interestingly, these are identical to the results obtained in previous publications [2,[4][5][6][7]. The current study also evaluated the dressing's hemostatic effect.…”

Section: Resultssupporting

confidence: 80%

“…At the early stage of wounds, the chitin dressing possibly increases fibroblasts which produce the fine type III collagen through histiocytes [3]. The regular chitin dressing has already been studied for many donor sites and local burn therapy, and the advantages of pain relief and protection of the wound have been acknowledged [2,[4][5][6][7]. When the covering gauze was changed with the regular chitin dressing under wet conditions after about three days, the sheet often broke and patients complained of pain (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Clinical application of new chitin non-woven fabric and new chitin sponge sheet as wound dressing

Ohshima

Nishino

et al. 1991

Eur J Plast Surg

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Two types of new chitin dressings, mesh reinforcement type and sponge-sheet type, were manufactured and applied to skin wounds such as burns and donor sites. The advantages include pain relief, wound hemostasis, adherence and drying. In comparison to the regular type of chitin, the new dressings show no autolysis or breaking and have possibilities for long-term use in wound with extensive exudate. No side effects were observed. Key words: Chitin-Wound dressing -Local therapy of burn Donor site As research in cultured skin is moving towards clinical realization, wound dressings are moving from protection of the skin defect to a synthetic cover which will replace skin.The excellent properties of regular chitin dressing, namely its good pain relief, adherence and drying effect, have been presented previously [6]. The current study Fig. 1. New chitin non-woven fabric, mesh-reinforcement type of Fig. 2 a, b. Chitin sponge sheet (a) and electron micrograph (b) 10 x 10 cm of chitin sponge ( x 50)

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Section: Resultssupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Clinical application of new chitin non-woven fabric and new chitin sponge sheet as wound dressing

Ohshima

Nishino

et al. 1991

Eur J Plast Surg

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“…Chitin and chitosan accelerate wound healing in humans and animals. 5,6 Various effects of chitin and chitosan on PMN migration, which is an important step in wound healing, were demonstrated. 8,10,11,34 Although it is clear that chitin and chitosan accelerate wound healing, 2-4 the mechanisms involved were not determined.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Wounds to which chitin and chitosan are applied show active and rapid accumulation of polymorphonuclear cells (PMNs), angiogenesis, and healing with little scarring. 7,8 Some investigators have reported on the mechanism by which chitin and chitosan act at a wounded site, which might involve activation of PMNs and macrophages, [9][10][11][12] a protective effect against microorganisms, 13 or promotion of granulation tissue formation with angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Chitin and chitosan stimulate canine polymorphonuclear cells to release leukotriene B4 and prostaglandin E2

Usami

Okamoto

Takayama

et al. 1998

J. Biomed. Mater. Res.

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The effects of chitin and chitosan on the release of arachidonic acid products were investigated in this study. Supernatants of canine polymorphonuclear cell (PMN) suspensions incubated with chitin and chitosan contained a leukotriene B4 (LTB4) concentration high enough to induce canine PMN migration in vitro. The supernatants also contained the same concentration of prostaglandin E2 (PGE2) as that normally found in the peripheral blood of dogs. Intraperitoneal administration of chitosan to dogs induced peritoneal exudative fluid (PEF), but chitin did not. The PEF contained numerous PMNs and macrophages. The supernatant of PEF contained both heat-stable and heat-labile chemotactic factors for canine PMNs. It also contained enough LTB4 to attract the canine PMNs in vitro.

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“…Chitosan that is formulated for wound management may induce analgesia by providing a cool, pleasant and soothing effect when applied to an open wound. Excellent pain relief is conferred by chitosan when it is applied as a topical agent to open wounds, such as burns, skin abrasions, skin ulcers and skin grafted areas (Ohshima et al, 1987). Chitosan-dependent antimicrobial activity has been observed against various microorganisms, such as fungi, algae and bacteria.…”

Section: Analgesic Antimicrobial and Anti-inflammatory Effects Of Chmentioning

confidence: 99%

Biomedical-Grade Chitosan in Wound Management and Its Biocompatibility In Vitro

Halim¹,

Lim²

2010

Biopolymers

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Clinical application of chitin non-woven fabric as wound dressing

Cited by 59 publications

References 8 publications

Clinical application of new chitin non-woven fabric and new chitin sponge sheet as wound dressing

Clinical application of new chitin non-woven fabric and new chitin sponge sheet as wound dressing

Chitin and chitosan stimulate canine polymorphonuclear cells to release leukotriene B4 and prostaglandin E2

Biomedical-Grade Chitosan in Wound Management and Its Biocompatibility In Vitro

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