Clinical application of infrared fibre-optic probes for the discrimination of colorectal cancer tissues and cancer grades

Ollesch, Julian; Zaczek, Michael; Heise, H. M.; Theisen, Oliver; Großerüschkamp, Frederik; Schmidt, Ralf; Morgenroth, K; Philippou, Stathis; Kemen, M.; Gerwert, Klaus

doi:10.1016/j.vibspec.2016.07.003

Cited by 12 publications

(9 citation statements)

References 38 publications

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“…This is consistent with the fact that tumor tissue-particularly poorly differentiated-is generally less structured resulting in easier exfoliation of the cells [37]. The relative intensity of these bands, however, is much smaller than observed in the previous studies where bulk tissues were analyzed [32,33]. With small incidence of other tumor types, thus far there is too little data for identification of significant spectral markers for their discrimination.…”

Section: Resultssupporting

confidence: 79%

Rapid intra‐operative diagnosis of kidney cancer by attenuated total reflection infrared spectroscopy of tissue smears

Pučetaitė

Velička

Urbonienė

et al. 2018

Journal of Biophotonics

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Herein, a technique to analyze air-dried kidney tissue impression smears by means of attenuated total reflection infrared (ATR-IR) spectroscopy is presented. Spectral tumor markers-absorption bands of glycogen-are identified in the ATR-IR spectra of the kidney tissue smear samples. Thin kidney tissue cryo-sections currently used for IR spectroscopic analysis lack such spectral markers as the sample preparation causes irreversible molecular changes in the tissue. In particular, freeze-thaw cycle results in degradation of the glycogen and reduction or complete dissolution of its content. Supervised spectral classification was applied to the recorded spectra of the smears and the test spectra were classified with a high accuracy of 92% for normal tissue and 94% for tumor tissue, respectively. For further development, we propose that combination of the method with optical fiber ATR probes could potentially be used for rapid real-time intra-operative tissue analysis without interfering with either the established protocols of pathological examination or the ordinary workflow of operating surgeon. Such approach could ensure easier transition of the method to clinical applications where it may complement the results of gold standard histopathology examination and aid in more precise resection of kidney tumors.

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Section: Resultssupporting

confidence: 79%

Rapid intra‐operative diagnosis of kidney cancer by attenuated total reflection infrared spectroscopy of tissue smears

Pučetaitė

Velička

Urbonienė

et al. 2018

Journal of Biophotonics

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“…These findings indicate that the spectra of tissue obtained using the current fiber-based ATR IR method contains the biochemical information of both components, the ECM and cells. It is also supported by the earlier work of Ollesch et al 11 . that spectral information can be obtained from the tissue using both diamond and Ge ATR crystal.…”

Section: Resultssupporting

confidence: 66%

“…Most of these studies only included a small number of resected and dried tissue samples in analytical laboratories far away from concrete clinical application. In one of the first papers on fiber optic IR spectroscopy of tumor tissue, Ollesch et al 11 . demonstrated that spectroscopic differentiation between normal and tumorous colon tissue is possible on native ex situ samples using supervised classification.…”

Section: Introductionmentioning

confidence: 99%

Fast and label-free intraoperative discrimination of malignant pancreatic tissue by attenuated total reflection infrared spectroscopy

et al. 2023

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“…The main advantages of using fiber spectroscopic methods are their being non-destructive and non-invasive, as well as avoiding the use of extrinsic contrast-enhancing agents. Application of the optical fiber approaches for the determination of the tissues affected by a tumor has been demonstrated ex vivo for the brain [ 15 ], colon [ 16 , 17 ], and skin [ 18 ]. Recently, it has been shown that a combination of spectroscopic methods can increase the effectiveness of cancer detection [ 15 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Synergy Effect of Combining Fluorescence and Mid Infrared Fiber Spectroscopy for Kidney Tumor Diagnostics

Bogomolov

Belikova

Zabaryło

et al. 2017

Sensors

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Matching pairs of tumor and non-tumor kidney tissue samples of four patients were investigated ex vivo using a combination of two methods, attenuated total reflection mid infrared spectroscopy and fluorescence spectroscopy, through respectively prepared and adjusted fiber probes. In order to increase the data information content, the measurements on tissue samples in both methods were performed in the same 31 preselected positions. Multivariate data analysis revealed a synergic effect of combining the two methods for the diagnostics of kidney tumor compared to individual techniques.

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Clinical application of infrared fibre-optic probes for the discrimination of colorectal cancer tissues and cancer grades

Cited by 12 publications

References 38 publications

Rapid intra‐operative diagnosis of kidney cancer by attenuated total reflection infrared spectroscopy of tissue smears

Rapid intra‐operative diagnosis of kidney cancer by attenuated total reflection infrared spectroscopy of tissue smears

Fast and label-free intraoperative discrimination of malignant pancreatic tissue by attenuated total reflection infrared spectroscopy

Synergy Effect of Combining Fluorescence and Mid Infrared Fiber Spectroscopy for Kidney Tumor Diagnostics

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