Clinical approach to colonic ischemia

Elder, Kareem; Lashner, Bret A.; Solaiman, Firas Al

doi:10.3949/ccjm.76a.08089

Cited by 122 publications

(84 citation statements)

References 45 publications

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“…However, elevated serum levels of lactate dehydrogenase, creatinekinase or amylase may indicate a colonic tissue injury. The combination of metabolic acidosis, increased leucocyte counts over 20x10 9 / l and abdominal pain may be suggestive of intestinal ischaemia [14].…”

Section: Discussionmentioning

confidence: 99%

Ischemic colitis problems of diagnosis and treatment

Meşină¹,

Dumitrescu²,

Obleagă³

et al. 2018

Arch Clin Exp Surg

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Section: Discussionmentioning

confidence: 99%

Ischemic colitis problems of diagnosis and treatment

Meşină¹,

Dumitrescu²,

Obleagă³

et al. 2018

Arch Clin Exp Surg

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“…Colonic ischemia presents clinically as a spectrum ranging from transient self-limited ischemia to severe transmural gangrenous necrosis of the colon (1,2). Although most cases can be treated conservatively, some require surgery, which has an associated mortality rate of up to 60% (3).…”

Section: Introductionmentioning

confidence: 99%

A Case of an Elderly Patient with Slowly Progressive Type 1 Diabetes Who Developed Severe Nonocclusive Mesenteric Ischemia without Predisposing Events

et al. 2012

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A 72-year-old woman with slowly progressive type 1 diabetes (SPIDDM) was admitted to our hospital because of increasing abdominal pain and diarrhea. The patient was diagnosed with nonocclusive mesenteric ischemia (NOMI), and a subtotal colonectomy was performed successfully. The resected sample revealed transmural gangrenous necrosis of the colon and rectum. This case is interesting because the severe NOMI occurred in a SPIDDM patient without common predisposing events such as hypoperfusion. Prolonged generation of reactive oxygen species in SPIDDM, together with the decline in adaptive response to oxidative stress with aging, might be an exacerbating factor for ischemic injury in the elderly.

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“…23 Some authors now suggest angiography may be useful when acute mesenteric ischemia is also considered in association with colon ischemia or in some cases of RSCI. 24,25 To our knowledge, this is the first detailed report on symptomatic large visceral artery occlusion and its treatment in survivors of RSCI.…”

Section: Original Research and Contributionsmentioning

confidence: 99%