Clinical aspects of pediatric AIDS cases notified in the state of Amazonas, 1991-2009

Soeiro, Claudia Marques de Oliveira; Miranda, Angélica Espinosa; Saraceni, Valéria; Talhari, Sinésio; Ferreira, Luíz Carlos de Lima

doi:10.1590/s1413-86702011000400025

Cited by 2 publications

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“…Of the 33 children who initiated antiretroviral treatment in 2001 and 2002, 25 remained alive and in follow-up at the end of these eleven years. The median age at admission to the service was 30 months, characterizing late diagnosis of the HIV infection, a characteristic that has been reported in other Brazilian studies [ 15 , 31 ]. Unlike the findings of the present study in which diagnosis and treatment were late, in the cohort study conducted with perinatally HIV-infected French adolescents’ diagnosis of the HIV infection was made at an early stage and most of the children initiated treatment prior to nine months of life [ 27 ].…”

Section: Discussionsupporting

confidence: 59%

Mortality in children and adolescents vertically infected by HIV receiving care at a referral hospital in Vitoria, Brazil

2015

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BackgroundDaily throughout 2011, about 900 new HIV infections occurred in children and 630 children died as a result of AIDS-related complications worldwide. Late diagnosis, mortality trends, causes of and risk factors for death were evaluated in vertically HIV-infected children.MethodsA retrospective 11-year study was conducted with Brazilian vertically HIV-infected children and adolescents using patients’ charts. Medical records, death certificates and the Ministry of Health’s mortality database were verified for mortality and cause of death. Diagnoses were made according to the CDC Revised Classification System for HIV infection.ResultsOf 177 patients included, 97 were female (54.8%). Median age at admission was 30 months (IQR: 5–72 months). Median follow-up was 5 years (IQR: 2–8 years). After 11 years, 132 (74,6%) patients continued in follow-up, 11 (6.2%) had been transferred and 8 (4.5%) were lost to follow-up. Twenty-six deaths occurred (14,7%), the majority (16/26; 61.5%) in children <3 years of age. Death cases decreased over time and the distribution of deaths was homogenous over the years of evaluation. In 17/26 (65.4%) of the children who died, diagnosis had been made as the result of their becoming ill. Beginning antiretroviral therapy before 6 months of age was associated with being alive (OR = 2.86; 95% CI: 1.12–7.25; p = 0.027). The principal causes of death were severe bacterial infections (57%) and opportunistic infections (33.3%).ConclusionsIn most of the HIV-infected children, diagnosis was late, increasing the risk of progression to AIDS and death due to delayed treatment. The mortality trend was constant, decreasing in the final two years of the study. Bacterial infections remain as the major cause of death. Improvements in prenatal care and pediatric monitoring are mandatory.

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Section: Discussionsupporting

confidence: 59%

Mortality in children and adolescents vertically infected by HIV receiving care at a referral hospital in Vitoria, Brazil

2015

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“…Matida et al (2011) reported that 51.7% of girls were affected with pediatric AIDS (12). However, a study conducted by Soeiro et al (2011) in Amazon, Brazil found a higher percentage of boys (58%) than girls among children with AIDS (13). Therefore, vertical transmission of HIV infection does not seem to be related to gender.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Epidemiological Profile and Survival of Children with AIDS in Santa Catarina, Brazil, 1988 - 2013

Schuelter-Trevisol

Crocetta

Magajewski

et al. 2016

Arch Pediatr Infect Dis

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Clinical aspects of pediatric AIDS cases notified in the state of Amazonas, 1991-2009

Cited by 2 publications

References 6 publications

Mortality in children and adolescents vertically infected by HIV receiving care at a referral hospital in Vitoria, Brazil

Mortality in children and adolescents vertically infected by HIV receiving care at a referral hospital in Vitoria, Brazil

Characterization of the Epidemiological Profile and Survival of Children with AIDS in Santa Catarina, Brazil, 1988 - 2013

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