Clinical Benefits of Circadian-based Antioxidant Protection and Repair

Draelos, Zoe Diana; Makino, Elizabeth T; Kadoya, Kuniko; Nguyen, Audrey; Jiang, Lily I.; Mehta, Rahul

doi:10.36849/jdd.2020.5355

Cited by 5 publications

(18 citation statements)

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“…While the results presented here are intriguing, there are some limitations to the data. In previously controlled studies for each product, LVS showed improvements in skin radiance and skin tone evenness, and LYT2 demonstrated comparable pigmentation control to the standard 4% HQ 15,17,18 …”

Section: Discussionmentioning

confidence: 88%

“…Combining multiple active ingredients into a single regimen may provide more comprehensive protection from the environment. The LVS product was formulated with a blend of protective antioxidants and therapeutic peptides to support skin homeostasis and combat the barrage of stressors that exacerbate hyperpigmentation, among other signs of premature skin aging 17,18 …”

Section: Discussionmentioning

confidence: 99%

“…The key ingredients for LVS and LYT2 have been detailed previously. 15,18 Patients were instructed to apply each of the LVS day and night serums once daily, along with LYT2 applied twice daily. Patients additionally had to adhere to a basic skincare routine consisting of a facial cleanser, moisturizer, and a broad-spectrum SPF 35 sunscreen (SkinMedica, Allergan Aesthetics, an AbbVie Company).…”

Section: Methodsmentioning

confidence: 99%

“…Patients were provided all study products and instructions for use. The key ingredients for LVS and LYT2 have been detailed previously 15,18 …”

Section: Methodsmentioning

confidence: 99%

“…In previously controlled studies for each product, LVS showed improvements in skin radiance and skin tone evenness, and LYT2 demonstrated comparable pigmentation control to the standard 4% HQ. 15,17,18 However, this longitudinal study only evaluated the combination of LYT2 and LVS without separate groups for the single agents. Thus, potential additive effects or synergies cannot be definitively extrapolated from this dataset.…”

Section: Re Sultsmentioning

confidence: 99%

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Clinical assessment of a circadian‐based antioxidant system combined with a comprehensive brightening serum in diverse subjects with moderate‐to‐severe facial hyperpigmentation

Shah¹,

Manry

Makino

et al. 2022

J of Cosmetic Dermatology

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Background Hyperpigmentation conditions can affect all skin types but occur more frequently in darker skin. Because many factors have been implicated in the etiologies of these disorders, multi‐targeted approaches may be required to achieve a better overall outcome in a diverse patient population. Aims The purpose of this study was to investigate the safety and efficacy of a combination regimen of a comprehensive cosmetic brightening agent (LYT2) with a broad blend of antioxidants (LVS) to reduce hyperpigmentation and improve overall skin appearance. Methods The combination of LYT2 and LVS, in addition to a basic skincare routine, was evaluated in subjects of either Caucasian or Asian (a majority of whom were Indian) descent, presenting with moderate‐to‐severe hyperpigmentation. Efficacy evaluations consisted of investigator clinical grading of overall hyperpigmentation, skin tone evenness, and radiance, as well as subject self‐assessment questionnaires. Results Immediate and progressive improvement was noted by the investigators for all assessed parameters. At the end of the 12‐week study, investigators observed a 45% mean decrease from baseline for overall hyperpigmentation. In addition, a 50% improvement in skin tone evenness and a 58% increase in radiance was observed. These investigator assessments were matched by good patient scores for self‐perceived efficacy parameters and high overall satisfaction. One patient (7%) showed a treatment‐related adverse event. Conclusion A combination skincare regimen that combines the pigmentation control of LYT2 with the broad antioxidant defense of LVS is a well‐tolerated and effective treatment option to improve the appearance of facial hyperpigmentation and make skin more radiant.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Patients were provided all study products and instructions for use. The key ingredients for LVS and LYT2 have been detailed previously 15,18 …”

Section: Methodsmentioning

confidence: 99%

Section: Re Sultsmentioning

confidence: 99%

See 3 more Smart Citations

Clinical assessment of a circadian‐based antioxidant system combined with a comprehensive brightening serum in diverse subjects with moderate‐to‐severe facial hyperpigmentation

Shah¹,

Manry

Makino

et al. 2022

J of Cosmetic Dermatology

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Melasma hyperpigmentation: An overview of current topical therapeutics

AlSalem

Alexis

2022

Dermatological Reviews

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Background Melasma is a common disorder of hyperpigmentation that affects populations globally and can adversely affect quality of life. Topical therapies—including hydroquinone and nonhydroquinone‐containing formulations—play a central role in the management of melasma. Methods A literature review was conducted using PubMed and Google Scholar. Search keywords included a combination of the following: “melasma,” “chloasma,” and “topical treatment.” We identified and included seminal and high‐quality peer‐reviewed publications, systematic reviews, randomized controlled trials, case series, case reports, consensus statements, and expert opinions. Results Topical therapies are widely used for the treatment of melasma. Triple combination cream containing hydroquinone, fluocinolone, and tretinoin is the most studied formulation with the strongest evidence among treatment options. Numerous other prescription‐based and nonprescription topical agents, including a growing list of cosmeceuticals, have been used in the treatment of melasma, albeit in smaller studies. Conclusion A growing range of topical agents is available for the treatment of melasma. While larger, more robust studies are warranted, nonhydroquinone cosmeceuticals may be useful adjuncts or alternatives to the gold standard of triple‐combination hydroquinone cream.

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Protective effects of a day/night dual‐antioxidant serum on skin: A randomized, regimen‐controlled study in Chinese women exposed to air pollution

Liu

Jie

Liú

et al. 2022

J of Cosmetic Dermatology

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Background Chronic exposure to air pollution can negatively affect skin health. Aims To assess the efficacy of the LUMIVIVE® System (LVS), a skincare system consisting of individual day and night serums, in Chinese women exposed to air pollution. Patients/Methods In this single‐center, vehicle‐controlled study, eligible females (mean age, 49.02 years) were randomized 1:1 to treatment group (LVS plus basic moisturizer) or control group (basic moisturizer). Skin color, sebum content, barrier function, elasticity, and texture were measured at baseline and at each follow‐up visit (days 28, 56, and 84). Air pollution parameters were collected throughout the study. Results Air pollution levels, including PM2.5 and NO2, were consistently high during the study. The treatment group showed significantly higher skin color L* (p ≤ 0.0001) and lower a* values (p ≤ 0.05) at all follow‐up visits compared with the control group, indicating lower skin pigmentation and redness, respectively. Skin color L* and a* values remained unchanged over time for the control group but were significantly different at all follow‐up visits compared to baseline (p ≤ 0.0001 and p ≤ 0.05, respectively) for the treatment group. There was an increasing trend for sebum content in the control group, which was not observed in the treatment group. Both groups showed improvements over time in other skin physiology parameters. Conclusions The current analysis demonstrates the efficacy of LVS plus basic moisturizer compared with basic moisturizer alone to reduce skin pigmentation and redness, as well as to mitigate sebum production, in Chinese women exposed to air pollution.

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Clinical Benefits of Circadian-based Antioxidant Protection and Repair

Cited by 5 publications

References 0 publications

Clinical assessment of a circadian‐based antioxidant system combined with a comprehensive brightening serum in diverse subjects with moderate‐to‐severe facial hyperpigmentation

Clinical assessment of a circadian‐based antioxidant system combined with a comprehensive brightening serum in diverse subjects with moderate‐to‐severe facial hyperpigmentation

Melasma hyperpigmentation: An overview of current topical therapeutics

Protective effects of a day/night dual‐antioxidant serum on skin: A randomized, regimen‐controlled study in Chinese women exposed to air pollution

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