Clinical Characteristics of Korean Type 2 Diabetic Patients According to Insulin Secretion and Insulin Resistance

Song, Kyoung Eun; Kim, Dae Jung; Park, Ji Won; Cho, Hong Keun; Lee, Kwan Woo; Huh, Kap Bum

doi:10.4093/jkda.2007.31.2.123

Cited by 10 publications

(7 citation statements)

References 5 publications

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“…It has been known that several causes, mainly obesity, environmental factors and inherited metabolic disease, are engaged in type 2 diabetes [ 10 ]. Among diverse metabolic disorders, increased IR and IIS are considered the most critical pathogenetic factors in the development type 2 diabetes [ 6 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients

et al. 2018

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BackgroundGenetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.MethodsOverall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.ResultsAmong calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.ConclusionVariations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.

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Section: Discussionmentioning

confidence: 99%

“…There are several studies that demonstrated the association between genetic variations in the genes coding adiponectin and IR, metabolic syndrome as well as the risk of type 2 diabetes in Korean population [ 10 11 ]. However, not much is known about the CAPN10 genetic polymorphism and metabolic derangements in Koreans.…”

Section: Introductionmentioning

confidence: 99%

Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients

et al. 2018

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“…In Korea, the proportions of patient with diabetes who are not obese was approximately 71.3% in the early 1980s [ 28 ], 68.5% in the early 1990s [ 29 , 30 ], and 57.5% in the mid-2000s [ 31 ]. These changes represent a decreased proportion of nonobese patients and an increased proportion of obese patients among subjects with diabetes, as well as the westernization of the T2DM phenotype.…”

Section: Discussionmentioning

confidence: 99%

The Insulin Resistance but Not the Insulin Secretion Parameters Have Changed in the Korean Population during the Last Decade

et al. 2015

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BackgroundThis study aimed to compare the patterns of insulin secretion and resistance between Korean subjects in the 1990s and 2000s.MethodsInsulin secretion and resistance indices were calculated from subjects who underwent 75-g oral glucose tolerance tests in the year 1997 to 1999 and 2007 to 2011 at the Seoul St. Mary's Hospital, Korea.ResultsA total of 578 subjects from the 1990s (mean age, 48.5 years) and 504 subjects from the 2000s (mean age, 50.2 years) were enrolled. Compared with the subjects from the 1990s, those from the 2000s exhibited increased insulin resistance (increased homeostatic model assessment for insulin resistance), and reduced insulin sensitivity (reduced Matsuda index and quantitative insulin sensitivity check index), regardless of their glucose tolerance status. However, insulinogenic index did not reveal significant differences between the 2 decades in subjects with or without diabetes. A distinct relationship was confirmed between Matsuda index and total area under the curve (insulin/glucose) in each glucose tolerance group. The mean product of the Matsuda index and the total area under the curve (insulin/glucose) as well as the oral disposition index, was lower in subjects with normal glucose tolerance from the 2000s than in those from the 1990s.ConclusionAfter rapid economic growth and changes in lifestyle patterns, insulin resistance has worsened across the glucose tolerance status; however, the insulin secretory function remained unchanged, which resulted in an increase in the susceptibility to the development of type 2 diabetes mellitus among Korean subjects without diabetes. We could not rule out the potential selection bias and therefore, further studies in general Korean population are needed.

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“…The incidence of diabetes over 30 years old has increased from 6.6% in 1998 to 8.1% in 2005 ( Ministry of Health and Welfare, 1999 ; Ministry of Health and Welfare, 2006 ), and many diabetic experts are predicting that the incidence of diabetes would increase steadily ( Rhee, 2003 ). Most of the Koreans have type 2, non-insulin dependent diabetes mellitus ( Song et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic effect of Chlorella vulgaris intake in type 2 diabetic Goto-Kakizaki and normal Wistar rats

2009

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The aim of this study was to examine the hypoglycemic effect of chlorella in 6 week-old type 2 diabetic Goto-Kakizaki (GK, n=30) rats and 6 week-old normal Wistar (n=30) rats. Animals were randomly assigned to 3 groups respectively, and were fed three different experimental diets containing 0%, 3% or 5% (w/w) chlorella for 8 weeks. In diabetic GK rats, the insulinogenic-indices were not significantly different among the groups. The concentrations of fasting plasma glucagon and hepatic triglyceride, and the insulin/glucagon ratios of the GK-3% chlorella and GK-5% chlorella groups were significantly lower than those of the GK-control group. The HOMA-index and the concentrations of fasting blood glucose and plasma insulin of the GK-3% chlorella and GK-5% chlorella groups were slightly lower than those of the GK-control group. In normal Wistar rats, the insulinogenic-indices were not significantly different among the normal groups, but that of the Wistar-5% chlorella group was slightly higher than the other groups. The concentrations of fasting blood glucose and plasma insulin, and the HOMA-index of the Wistar-5% chlorella group were a little higher, and the fasting plasma glucagon concentration and the insulin/glucagon ratio of the Wistar-5% chlorella group were significantly higher than those of the Wistar-control and Wistar-3% chlorella groups. In conclusion, this study shows that the glucose-stimulated insulin secretion was not affected by the intake of chlorella, which could be beneficial, however, in improving insulin sensitivity in type 2 diabetic GK and normal Wistar rats.

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Clinical Characteristics of Korean Type 2 Diabetic Patients According to Insulin Secretion and Insulin Resistance

Cited by 10 publications

References 5 publications

Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients

Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients

The Insulin Resistance but Not the Insulin Secretion Parameters Have Changed in the Korean Population during the Last Decade

Hypoglycemic effect of Chlorella vulgaris intake in type 2 diabetic Goto-Kakizaki and normal Wistar rats

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