Clinical effect of locally delivered gel containing green tea extract as an adjunct to non-surgical periodontal treatment

Rattanasuwan, Kanyawat; Rassameemasmaung, Supanee; Sangalungkarn, Vanida; Komoltri, Chulaluk

doi:10.1007/s10266-014-0190-1

Cited by 28 publications

(20 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The main idea behind these investigations is to reveal the further potential of the combined gel preparation to combat periodontal disease in closer than clinical situations. This was the outlook investigated in the studies published by [ 40 , 41 ]. The authors evaluated the efficiency of a green tea Catechin gel as an adjunct on human periodontal therapy.…”

Section: Resultsmentioning

confidence: 80%

“…In first work [ 40 ], the authors observed a significant reduction on pockets and inflammation during the 4 weeks of the clinical trial. In the second work [ 41 ], it was demonstrated that when used as an adjunct to periodontal treatment, green tea gel could provide benefit in reducing bleeding on probing and gingival inflammation at 1st and 3rd months of evaluation. What makes these studies even more relevant is the fact that the findings on complementary products for the treatment of human periodontitis still can be enhanced.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review

Oliveira

Pinto

Santana

et al. 2016

International Journal of Dentistry

View full text Add to dashboard Cite

Objective. The aim of this systematic review was to investigate the advances in the study of medicinal plants and their biologic effects on periodontitis in animal models. Study Design. A systematic search was conducted by three independent researchers, who screened articles published up to March/2016, to identify the studies that contained sufficient and clear information on the association of the medicinal plants and periodontitis in murine models. The searches were performed using PubMed, Cochrane, and Science Direct databases. Results. After a critical analysis of titles and abstracts, 30 studies were finally eligible for analysis. The studies presented a great diversity of the experiment designed regarding the methods of induced periodontitis and the evaluation of the medicinal plants efficacy. None of the studies described the possible toxic effects associated with the administration of the plant material to animals and whether they could prevent damage to organs caused by systemic effect of induced periodontitis. Gel-based formulations containing plant substances are seen as an interesting strategy to treat periodontitis. Conclusions. In this systematic review, the state-of-the-art knowledge on the medicinal plants and the induced periodontitis was critically evaluated and discussed from the experiment designed to the possible clinical application.

show abstract

Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review

Oliveira

Pinto

Santana

et al. 2016

International Journal of Dentistry

View full text Add to dashboard Cite

show abstract

“…To date, many studies have shown the potential treatment effects of catechins on periodontitis in vitro and in vivo . Recently, locally delivered green tea extract gel has been used as an adjunct to nonsurgical periodontal treatment . However, few studies have shown the potential effects of TFs in the control of periodontal disease, and these studies were limited to in vitro experiments .…”

Section: Introductionmentioning

confidence: 99%

“…28,29 Recently, locally delivered green tea extract gel has been used as an adjunct to nonsurgical periodontal treatment. 30 However, few studies have shown the potential effects of TFs in the control of periodontal disease, and these studies were limited to in vitro experiments. 27 Thus, both the in vivo effects of TFs on individual inflammatory responses and the possibility for clinical application are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats

Kuraji

Taya

et al. 2018

J of Periodontal Research

View full text Add to dashboard Cite

Background and ObjectiveTheaflavins (TFs), the major polyphenol in black tea, have the ability to reduce inflammation and bone resorption. The aim of this study was to evaluate the effects of TFs on experimental periodontitis in rats.Material and MethodsThirty rats were divided into five groups: Control (glycerol application without ligation), Ligature (glycerol application with ligation), TF1 (1 mg/mL TF application with ligation), TF10 (10 mg/mL TF application with ligation), and TF100 (100 mg/mL TF application with ligation). To induce experimental periodontitis, ligatures were placed around maxillary first molars bilaterally. After ligature placement, 100 μL glycerol or TFs were topically applied to the rats daily, and rats were euthanized 7 days after ligature placement. Micro‐computed tomography was used to measure bone resorption in the left side of the maxilla, and quantitative polymerase chain reaction was used to measure the expression of interleukin (IL)‐6, growth‐regulated gene product/cytokine‐induced neutrophil chemoattractant (Gro/Cinc‐1, rat equivalent of IL‐8), matrix metalloproteinase‐9 (Mmp‐9), receptor activator of nuclear factor‐kappa Β ligand (Rankl), osteoprotegerin (Opg), and the Rankl/Opg ratio in gingival tissue. With tissue from the right side of the maxilla, hematoxylin and eosin staining was used for histological analysis, immunohistochemical staining for leukocyte common antigen (CD45) was used to assess inflammation, and tartrate‐resistant acid phosphatase (TRAP) staining was used to observe the number of osteoclasts.ResultsThe TF10 and TF100 groups, but not the TF1 group, had significant inhibition of alveolar bone loss, reduction in inflammatory cell infiltration in the periodontium, and significantly reduced numbers of CD45‐positive cells and TRAP‐positive osteoclasts compared with the Ligature group. Correspondingly, the TF10 and TF100 groups had significantly downregulated gene expression of IL‐6, Gro/Cinc‐1(IL‐8), Mmp‐9, and Rankl, but not of Opg. Consequently, Rankl/Opg expression was significantly increased in the Ligation group but was attenuated in the TF10 and TF100 groups.ConclusionThe results of this study suggest that topical application of TFs may reduce inflammation and bone resorption in experimental periodontitis. Therefore, TFs have therapeutic potential in the treatment of periodontal disease.

show abstract

“…Outro estudo realizou a administração da EGCG via gavagem em camundongos após a indução experimental da doença periodontal e observou-se que houve uma inibição de TNF, IL-6 e diminuição do número e atividade dos osteoclastos reduzindo, assim, a perda óssea alveolar (Cho et al, 2013). Estudos clínicos em humanos foram realizados utilizando-se uma formulação de tiras do extrato do chá (Kudva et al, 2011;Gadagi et al, 2013) ou em formulações à base de gel (Rattanasuwan et al, 2014) colocadas subgengivalmente após o procedimento de raspagem e polimento radicular. Em todos esses estudos houve uma melhora significativa da condição óssea e periodontal em comparação ao grupo controle.…”

Section: Introductionunclassified

Formulação à base de Epigalocatequina-3-galato, derivada do chá verde, desenvolvida para uso endodôntico: estudo físico-químico e biológico

Ferreira¹

View full text Add to dashboard Cite

Clinical effect of locally delivered gel containing green tea extract as an adjunct to non-surgical periodontal treatment

Abstract: MU-IRB 2008/153.0511, ClinicalTrials.gov NCT00918060).

Cited by 28 publications

References 46 publications

Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review

Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review

Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats

Formulação à base de Epigalocatequina-3-galato, derivada do chá verde, desenvolvida para uso endodôntico: estudo físico-químico e biológico

Contact Info

Product

Resources

About