Clinical effects of purified air administered to the breathing zone in allergic asthma: A double-blind randomized cross-over trial

Pedroletti, Christophe; Millinger, Eva; Dahlén, Barbro; Söderman, P.; Zetterström, Olle

doi:10.1016/j.rmed.2009.03.020

Cited by 43 publications

(44 citation statements)

References 15 publications

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“…This study was designed to evaluate the effect of TLA on self-reported quality of life, and the small numbers of patients with acute asthma exacerbations during the study limited our power to evaluate whether TLA treatment reduces exacerbation rates. The effects of TLA on quality of life and FENO are consistent with previous pilot work using TLA 20. The clinical effects of nocturnal TLA treatment appear to be applicable to a broad patient group, because our study population included a wide age range of patients sensitised to a variety of perennial allergens, recruited in six countries.…”

Section: Discussionsupporting

confidence: 77%

Nocturnal temperature controlled laminar airflow for treating atopic asthma: a randomised controlled trial

Boyle

Pedroletti

Wickman

et al. 2011

Thorax

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ObjectiveTo determine whether environmental control using nocturnal temperature controlled laminar airflow (TLA) treatment could improve the quality of life of patients with persistent atopic asthma.DesignRandomised, double-blind, placebo-controlled, parallel-group trial.SettingNineteen European asthma clinics.Participants312 patients aged 7–70 with inadequately controlled persistent atopic asthma.Main outcome measureProportion of patients with an increase of ≥0.5 points in asthma quality of life score after 1 year of treatment.ResultsTLA devices were successfully installed in the bedrooms of 282 (90%) patients included in the primary efficacy analysis. There was a difference in treatment response rate between active (143 of 189, 76%) and placebo (56 of 92, 61%) groups, difference 14.8% (95% CI 3.1 to 26.5, p=0.02).3 In patients aged ≥12, on whom the study was powered, the difference in response rate was similar-active 106 of 143 (74%), placebo 42 of 70 (60%), difference 14.1% (0.6 to 27.7, p=0.059). There was a difference between groups in fractional exhaled nitric oxide change of −7.1 ppb (−13.6 to −0.7, p=0.03). Active treatment was associated with less increase in cat-specific IgE than placebo. There was no difference in adverse event rates between treatment groups.ConclusionInhalant exposure reduction with TLA improves quality of life, airway inflammation and systemic allergy in patients with persistent atopic asthma. TLA may be a treatment option for patients with inadequately controlled persistent atopic asthma.Trial registration numberClinical Trials NCT00986323.

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Section: Discussionsupporting

confidence: 77%

Nocturnal temperature controlled laminar airflow for treating atopic asthma: a randomised controlled trial

Boyle

Pedroletti

Wickman

et al. 2011

Thorax

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“…Three studies, one by Morris et al [34] and more recent ones by Pedroletti et al [35] and Stillerman et al [36•], looked at various HEPA SBZ filtration systems. Morris et al [34] studied the use of a laminar flow HEPA unit that could be positioned over the SBZ.…”

Section: Studies Of Portable Room and Sleep Breathing Zone Air Cleanersmentioning

confidence: 99%

Effectiveness of Air Filters and Air Cleaners in Allergic Respiratory Diseases: A Review of the Recent Literature

Sublett

2011

Curr Allergy Asthma Rep

107

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Air filtration is frequently recommended as a component of environmental control measures for patients with allergic respiratory disease. Residential air filtration can be provided by whole house filtration via the home’s heating, ventilation, or air conditioning system, by portable room air cleaners, or a combination of the two. Appliances to filter the sleep breathing zone also have been developed. High-efficiency whole house filtration, high-efficiency particulate air sleep zone air filtration, and high-efficiency particulate air room air cleaners all appear to provide various degrees of benefit. Recent studies of various types of filtration, used alone or as part of more comprehensive environmental control measures, are reviewed.

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“…The aim is to minimize the exposure to inhaled allergens and hence reduce the allergy-induced inflammation and improve disease control in atopic patients [100]. Two randomized double-blinded control studies on adults and children (from 7 years) with allergic asthma have shown improvement in disease-related quality of life and reduction in airways inflammation [101,102]. Subgroup analysis has showed the largest effect on patients with the most severe disease.…”

Section: Temperature-controlled Laminar Airflowmentioning

confidence: 99%

Update on the current methods for the diagnosis and treatment of severe childhood asthma

Konradsen

Osvald

Hedlin

2015

Expert Review of Respiratory Medicine

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The level of asthma control is the key outcome towards which asthma management is evaluated. The majority of children with asthma can obtain adequate control of symptoms through avoidance of triggering factors and/or with the help of low to moderate doses of current available medications. However, there is still a group of children with poor symptom control despite intensive treatment. The current review will provide an overview of a standardized approach to characterize this heterogeneous group of severely sick children. Factors that attenuate the effect of the prescribed treatment and make asthma difficult to treat are discussed. In addition, the usefulness of current methods of assessing asthma severity, pulmonary function, allergy and airway inflammation is also described. Finally, an overview of therapeutic options for children with severe asthma is provided.

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Clinical effects of purified air administered to the breathing zone in allergic asthma: A double-blind randomized cross-over trial

Abstract: Clean air, administered directly to the breathing zone during sleep, can have a positive effect on bronchial inflammation and quality of life in patients with perennial allergic asthma.

Cited by 43 publications

References 15 publications

Nocturnal temperature controlled laminar airflow for treating atopic asthma: a randomised controlled trial

Nocturnal temperature controlled laminar airflow for treating atopic asthma: a randomised controlled trial

Effectiveness of Air Filters and Air Cleaners in Allergic Respiratory Diseases: A Review of the Recent Literature

Update on the current methods for the diagnosis and treatment of severe childhood asthma

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