Clinical efficacy of two vaccination strategies against Mycoplasma hyopneumoniae in a pig herd suffering from respiratory disease

Cvjetković, Vojislav; Sipos, Sabine; Szabó, Imre; Sipos, Wolfgang

doi:10.1186/s40813-018-0092-7

Cited by 15 publications

(15 citation statements)

References 22 publications

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“…Vaccination schemes frequently used in the European region are traditional two-shot formulations, one-shot formulations, and bivalent one-shot formulations containing both M. hyopneumoniae and porcine circovirus type 2 (PCV2) antigens. In general, vaccination reduces the occurrence of clinical signs and lung lesions and improves performance, but on the other hand does not prevent colonisation of the respiratory tract epithelia by mycoplasma organisms (Cvjetković et al 2018 ).…”

Section: Vaccinationmentioning

confidence: 99%

Prevention Is Better Than Cure

Pokludová

2020

Antimicrobials in Livestock 1: Regulation, Science, Practice

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Preventive measures and health programmes should help significantly to keep animals healthy. If animal welfare principles and good animal husbandry practices are also followed, minimal or no use of antimicrobials can be, with high probability, achieved. Setting priorities in biosecurity, which fits exact conditions of farm/husbandry is vital. Thorough mechanic cleaning, rational use of disinfection, disinsection and deratisation, proper ventilation and keeping the proper temperature and humidity contribute to keep good environment both in old stables and hi-tech husbandries. Health programmes, including vaccination tailored for local conditions, animal species and technologies used in the respective husbandry should be defined by educated veterinarians, specialised not only on treatment, but also on preventive medicine, use of alternatives to antimicrobials and management. Close cooperation of vets, farmers and people taking immediate care of animals and facilities is the basic prerequisite of the effectivity of such system. Therefore, tools for motivation and socio-economical aspects also belong among the key elements for effective preventive measures, which finally can help to minimise or skip the use of antimicrobials and help to combat antimicrobial resistance.

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Section: Vaccinationmentioning

confidence: 99%

Prevention Is Better Than Cure

Pokludová

2020

Antimicrobials in Livestock 1: Regulation, Science, Practice

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“…У щеплених тварин стійкий імунітет формується через 14 днів після вакцинації і триває протягом 6 місяців. Для підтримання імунітету рекомендується ревакцинація одноразовим щепленням що півроку (Cvjetkovic, Sipos, Szabo, & Sipos, 2018).…”

Section: актуальність темиunclassified

“…Автори робіт (Tao, Shu, Chen, Wu, & He, 2019) вважають, що схеми вакцинації повинні залежати від типу господарства, системи виробництва та від характеристики інфекції у стаді. Хоча захист від клінічної пневмонії часто неповний, а вакцини не попереджають колонізацію, деякі дослідники (Cvjetkovic, Sipos, Szabo, & Sipos, 2018)…”

Section: результати та їх обговоренняunclassified

Etiology of porcine enzootic pneumonia and control strategies on the farms of Zaporizhzhya and Poltava regions

Golovko¹,

Severyn²,

Ivanchenko³

et al. 2019

VTTP

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Porcine enzootic pneumonia is a multifactorial disease, it leads to large and significant economic losses in pig farms and it remains a relevant veterinary problem. The involvement of new etiological agents in the association of pathogens and the constantly changing conditions on the farms lead to the fact that previously developed control schemes and methods of disease lost their effectiveness. Therefore, the identification of all the infectious agents that make up the association, as well as the concomitant factors that led to the occurrence of the disease in each case is the only correct way to control measures.When we studied the situation in pig farms in the south and in the central region of Ukraine, we found that mycoplasmas were the main etiological agent for Porcine enzootic pneumonia. We noted that mycoplasmosis as a monoinfection was recorded only in 9-12 % of cases. In most outbreaks Mycoplasmas were only members of associations along with Porcine reproductive and respiratory syndrome infection (6%), Type 2 Circovirus infection (6%), enterbacterias (19%) and pasterellas (59%).The course of the disease was also aggravated by the stress of early weaning of piglets and violations of the conditions of feeding and animal welfare.The most difficult enzootic pneumonia occurred in those farms where mycoplasmosis and pasteurellosis were exacerbated by the presence of pathogens of actinobacillus pleuropneumonia. In such farms the average daily weight gain decreased in piglets by a third and feed consumption increased to 28 %.Piglets on affected farms were ill with obvious respiratory clinical signs. And 82% of dead or killed piglets had signs of fibrinous pleuropneumonia or catarrhal pneumonia.In those farms where we recorded associated respiratory infections, we also found reproductive-neonatal infections of pigs.In such farms treatment and prophylactic measures using traditional antimicrobial special remedies and monovaccines, did not give the expected effect.We proposed the use of autovaccines for associated enzootic pneumonia.

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“…Enzootic pneumonia (EP), caused by Mycoplasma hyopneumoniae, is one of the most common and significant economically infectious diseases in pig husbandry worldwide [1]. As a chronic respiratory disease, it is characterized by high morbidity, low mortality with dry and non-productive cough, causing a reduced average daily weight gain and poor feed conversion efficiency [2,3]. M.…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of an indirect ELISA for the detection of Mycoplasma hyopneumoniae natural infection but not inactivated bacterin vaccination

Ding

Wen

et al. 2020

Preprint

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Background: Mycoplasma hyopneumoniae is the primary pathogen of enzootic pneumonia (EP). Vaccination with inactivated bacterin is the most popular and practical measure to control EP. However, these commercial vaccines have a limited effect on the transmission of microorganism and cannot prevent colonization. Therefore, after immunization with inactivated bacterin, M. hyopneumoniae colonized on the respiratory tract and lungs stimulates the humoral immune responses and produce IgG and IgA antibodies. ELISA is a widely used serological method to detect M. hyopneumoniae antibodies. However, commercial IgG ELISA kit cannot distinguish between inactivated bacterin-induced hyperimmune sera and convalescent sera stimulated by natural infection. SIgA ELISA method is laborious for nasal swab collection, and the amount of each swab sample obtained from the nasal cavity is less compared to the serum sample. Establishment of a discriminative ELISA detecting humoral IgG from convalescent sera but not hyperimmune sera facilitates to evaluate the natural infection of M. hyopneumoniae after inactivated bacterin vaccination. Result: We expressed and purified a recombinant protein named Mhp366-N which contains an epitope recognized by the convalescent sera but not hyperimmune sera. The developed discriminative IgG-ELISA could discriminate between inactivated bacterin-induced hyperimmune sera and convalescent sera, and was reproducible, sensitive, and specific to M. hyopneumoniae antibody produced by natural infection. Compared to sIgA-ELISA method, discriminative IgG-ELISA was more convenient to detect IgG antibody from sera than IgA from nasal swabs, although it has limited sensitivity in the early stages of infection. Additionally, to some extent, it has a potential to avoid the interference of maternally derived IgG antibodies. Conclusions: The established discriminative IgG-ELISA was efficient to judge the serological IgG antibodies induced from natural infection or inactivated vaccine stimulation and provided a useful method to investigate and evaluate the live organism infection after the application of inactivated bacterin.

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Clinical efficacy of two vaccination strategies against Mycoplasma hyopneumoniae in a pig herd suffering from respiratory disease

Cited by 15 publications

References 22 publications

Prevention Is Better Than Cure

Prevention Is Better Than Cure

Etiology of porcine enzootic pneumonia and control strategies on the farms of Zaporizhzhya and Poltava regions

Development and evaluation of an indirect ELISA for the detection of Mycoplasma hyopneumoniae natural infection but not inactivated bacterin vaccination

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