Clinical Epidemiology of Reduced Kidney Function among Elderly Male Fishing and Agricultural Population in Taipei, Taiwan

Kuo, Chi-Mei; Chien, Wu-Hsiung; Shen, Hsiu-Nien; Hu, Yichun; Chen, Yu-Fen; Tung, Tao‐Hsin

doi:10.1155/2013/214128

Cited by 7 publications

(9 citation statements)

References 33 publications

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“…Renal functional decline is an important cause of hyperuricemia due to reduced uric acid clearance. 12 We found that the indicators of decreased renal function including eGFR, serum homocysteine, serum urea and Scr were significantly different between the hyperuricemia group and the normouricemia group. In addition, a low eGFR and a high serum urea level were independent risk factors for hyperuricemia.…”

Section: Discussionmentioning

confidence: 69%

<p>Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians</p>

Han¹,

Zhang²,

Zhao³

et al. 2019

CIA

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Hyperuricemia is an important potential pathogenic factor for hypertension, cardiovascular disease and stroke. The current study aimed to investigate the prevalence of hyperuricemia and its relationship to lifestyle characteristics and dietary habits in centenarians and near-centenarians. Patients and methods: In total, 966 centenarians and 788 near-centenarians were included. Community-based surveys were conducted to collect information about lifestyle. Blood examinations were performed using enzymatic assays. T-tests and χ2 tests were used to investigate significant indicators of hyperuricemia, and multivariate logistic regression was used to analyze the related risk factors. A comprehensive analysis of nineteen modifiable factors, including lifestyle characteristics, dietary habits, general characteristics and blood test indexes, was conducted. Results: The prevalence of hyperuricemia was 29.02%. The percentage of men, waist circumference (WC), waist-hip ratio, estimated glomerular filtration rate (eGFR), levels of total protein (TP), alanine aminotransferase, aspartate aminotransferase, triglycerides, highdensity lipoprotein cholesterol, serum homocysteine, serum uric acid, serum urea and serum creatinine, passive smoking, alcohol consumption, snoring, preference for fried flavors, and meat, seafood and vegetable consumption were significantly different between the hyperuricemia group and the normouricemia group (p<0.05). Multivariate logistic regression analysis showed that WC (OR=1.020), eGFR (OR=0.960), TP level (OR=1.038), serum urea level (OR=1.154), passive smoking (OR=2.589), snoring (OR=2.003), meat consumption (OR=2.506), seafood consumption (OR=1.422) and vegetable consumption (OR=0.521) were significantly associated with the risk of hyperuricemia (p<0.05). Conclusion: Low eGFR and vegetable consumption, high WC, TP, and serum urea levels, passive smoking, snoring, and high meat and seafood consumption were independent risk factors for hyperuricemia. It is recommended that people at high risk for hyperuricemia should actively limit their intake of fried food, alcohol and purine-rich food, increase their intake of fresh vegetables, actively treat sleep apnea syndrome, avoid passive smoking, maintain a healthy WC and seek to improve their kidney and liver function.

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Section: Discussionmentioning

confidence: 69%

<p>Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians</p>

Han¹,

Zhang²,

Zhao³

et al. 2019

CIA

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“…Prevalence of CKD also increases in age [28]. Hyperuricemia may be one of the strongest risk factors related to CKD in elderly population [29]. The elderly population has a higher level of SUA and a high risk of developing CKD [12].…”

Section: Discussionmentioning

confidence: 99%

Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China

Yang

Zhou²,

Wang

et al. 2019

Renal Failure

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Objective : To evaluate the association between serum uric acid (SUA) levels with CKD in elderly health checkup population and explore the gender difference. Methods: A total of 4242 subjects were included in the cross-sectional study. All of the subjects participated in the annual checkup between June 2016 and June 2017. Chronic kidney disease (CKD) was defined by estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m 2 . We examined the association between SUA levels and CKD. Multivariate binary logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) by comparing association between the SUA level and CKD. The models were adjusted for age, gender, body mass index (BMI), hypertension, diabetes, triglyceride and high-density lipoprotein cholesterol (HDL-C). Result: The prevalence of hyperuricemia was 22.2%, and it was significantly higher in male than in female (25.2% vs. 17%, p < .001). The prevalence of hyperuricemia increased with age, especially in the female. The prevalence of CKD was 27.8% in male and 20.2% in female ( p < .001). Compared with the SUA first quartile, the multivariate-adjusted odds for CKD of fourth quartiles were 6.05 (95%CI: 4.32–8.49) in male and 8.21(95%CI: 5.37–12.54) in female. Conclusion: Our finding showed gender-specific differences in the association between high SUA and an increased risk of CKD in the elderly population. The association of SUA and CKD was independent of other potential confounding factors including age, glucose, hypertension, HDL, TG and BMI.

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“…Blood pressure was measured twice for each subject in the sitting position, with an interval of 15 minutes between measurements, using a standard sphygmomanometer of appropriate width after a rest period for 30 minutes. Those taking antihypertensive therapy were considered to have known hypertension 8. Fasting blood samples were drawn via venipuncture by clinical nurses.…”

Section: Methodsmentioning

confidence: 99%

“…Those taking antihypertensive therapy were considered to have known hypertension. 8 Fasting blood samples were drawn via venipuncture by clinical nurses. Overnight fasting serum and plasma samples (from whole blood preserved with ethylenediamine tetraacetic acid and sodium fluoride) were kept frozen at −20°C until ready for analysis.…”

Section: Methodsmentioning

confidence: 99%

Relationship between obesity, metabolic syndrome, and nonalcoholic fatty liver disease in the elderly agricultural and fishing population of Taiwan

Shen¹,

Zhao²,

Hu³

et al. 2014

CIA

Self Cite

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BackgroundThe purpose of this study was to explore the relationship between obesity, the metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD) in the elderly agricultural and fishing population of Taipei, Taiwan.MethodsThe study participants comprised 6,511 (3,971 male and 2,540 female) healthy elderly subjects voluntarily attending a teaching hospital for a physical check-up in 2010. Blood samples and real-time ultrasound-proven fatty liver sonography results were collected.ResultsThe prevalence of NAFLD in this elderly population was 27.2%, including mild NAFLD (16.0%), moderate NAFLD (10.3%), and severe NAFLD (0.9%). The prevalence of moderate or severe NAFLD for metabolic syndrome proved to be substantially greater (P<0.0001, χ2 test) for one or two metabolic factors. Using multinomial logistic regression analysis, age, sex, metabolic syndrome, and higher body mass index had a statistically significant association with mild NAFLD. Age, sex, metabolic syndrome, higher body mass index, and higher alanine aminotransferase were significantly related to moderate NAFLD. In addition, higher body mass index, higher uric acid, and higher alanine aminotransferase levels were significantly related to severe NAFLD. The sensitivity and specificity of body mass index and waist circumference as markers of NAFLD were estimated to be 81% and 84%, respectively, and 77% and 69%, respectively.ConclusionThe prevalence of mild or moderate NAFLD was related to obesity and metabolic syndrome. Higher body mass index was also related to severe NAFLD but not to metabolic syndrome. Targeting this population for control of obesity and improved metabolic function is important.

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Clinical Epidemiology of Reduced Kidney Function among Elderly Male Fishing and Agricultural Population in Taipei, Taiwan

Cited by 7 publications

References 33 publications

<p>Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians</p>

<p>Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians</p>

Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China

Relationship between obesity, metabolic syndrome, and nonalcoholic fatty liver disease in the elderly agricultural and fishing population of Taiwan

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