<p>Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians</p>

Abstract

Hyperuricemia is an important potential pathogenic factor for hypertension, cardiovascular disease and stroke. The current study aimed to investigate the prevalence of hyperuricemia and its relationship to lifestyle characteristics and dietary habits in centenarians and near-centenarians. Patients and methods: In total, 966 centenarians and 788 near-centenarians were included. Community-based surveys were conducted to collect information about lifestyle. Blood examinations were performed using enzymatic assays. T-tests and χ2 tests were used to investigate significant indicators of hyperuricemia, and multivariate logistic regression was used to analyze the related risk factors. A comprehensive analysis of nineteen modifiable factors, including lifestyle characteristics, dietary habits, general characteristics and blood test indexes, was conducted. Results: The prevalence of hyperuricemia was 29.02%. The percentage of men, waist circumference (WC), waist-hip ratio, estimated glomerular filtration rate (eGFR), levels of total protein (TP), alanine aminotransferase, aspartate aminotransferase, triglycerides, highdensity lipoprotein cholesterol, serum homocysteine, serum uric acid, serum urea and serum creatinine, passive smoking, alcohol consumption, snoring, preference for fried flavors, and meat, seafood and vegetable consumption were significantly different between the hyperuricemia group and the normouricemia group (p<0.05). Multivariate logistic regression analysis showed that WC (OR=1.020), eGFR (OR=0.960), TP level (OR=1.038), serum urea level (OR=1.154), passive smoking (OR=2.589), snoring (OR=2.003), meat consumption (OR=2.506), seafood consumption (OR=1.422) and vegetable consumption (OR=0.521) were significantly associated with the risk of hyperuricemia (p<0.05). Conclusion: Low eGFR and vegetable consumption, high WC, TP, and serum urea levels, passive smoking, snoring, and high meat and seafood consumption were independent risk factors for hyperuricemia. It is recommended that people at high risk for hyperuricemia should actively limit their intake of fried food, alcohol and purine-rich food, increase their intake of fresh vegetables, actively treat sleep apnea syndrome, avoid passive smoking, maintain a healthy WC and seek to improve their kidney and liver function.

Dietary Inflammatory Index and the Risk of Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents

“…Meanwhile, in the DII calculation, there was no differentiation between plant-sourced proteins and animal-sourced proteins. A higher intake of protein and fat may also suggest a higher intake of animal food, which is thought to be associated with hyperuricemia [30]. We also found that alcohol intake in the hyperuricemia group was higher than the nonhyperuricemia group, which was consistent with other studies.…”

Neck Circumference Is Associated With Hyperuricemia in Women With Polycystic Ovary Syndrome

“…In contrast, measuring anthropometric indices such as body mass index (BMI), neck circumference (NC), waist circumference (WC) and hip circumference (HC) using tape or a scale is relatively easy (11). It has been confirmed that BMI (12)(13)(14), waist circumference (15)(16)(17) and hip circumference are positively correlated with the risk of hyperuricemia in different populations. However, it is not always feasible and accurate to measure WC, HC and BMI in the winter with heavy clothes or postprandially.…”

Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort Study

“…An effective strategy is urgently needed to decrease the levels of serum urate for patients with hyperuricemia. Dietary factors and lifestyle were attached to an important concern in related studies owing to the characteristics of changeability (11)(12)(13)(14).…”