Clinical features of genital lichen sclerosus et atrophica in males and females

Гребенюк, В. Н.; Доля, О. В.; Соколова, А. А.; Grebenyuk, V. N.; Dolya, O. V.

doi:10.17116/klinderma2016151554-59

Cited by 4 publications

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References 4 publications

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“…В начальной стадии заболевания склероатрофический лихен может не проявляться клинически, и пациенты зачастую обращаются к урологу только при появлении симптомов затруднённого мочеиспускания. на этом этапе заболевания формируются фиброзно-склеротические изменения в слизистой оболочке уретры и на крайней плоти полового члена, приводящие к стриктуре уретры и / или рубцовому фимозу, вызывая нарушение адекватного мочеиспускания и снижение качества жизни [2,3]. известным является тот факт, что необрезанные мужчины более часто подвержены заболеванию генитальным lichen sclerosus, чем обрезанные [4].…”

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Urethral strictures caused by lichen sclerosus: evaluation of patient quality of life after buccal urethroplasty

et al. 2022

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Introduction. In modern medical practice, when conducting clinical trials to assess the effectiveness of the treatment, it has long been recognized that the quality of life of a patient is a highly informative indicator of the assessment of health status. Buccal urethroplasty is one of the most effective methods of surgical treatment of urethral stricture disease in men with scleroatrophic lichen.Materials and methods. Twenty-five patients with urethral stricture caused by scleroatrophic lichen aged 17 to 80 years were examined. All patients underwent surgical treatment in the form of buccal urethroplasty. Of these, 21 patients with extended urethral strictures, and 6 patients with recurrent strictures and urethral obliteration. The study of various aspects of the quality of life of patients after buccal urethroplasty included the study of IPSS, QoL, SF-36 and urodynamic parameters 1, 6, and 12 months after surgery, as well as satisfaction with the results of the operation by the patients themselves.Results. When comparing the results of the SF-36 questionnaire, they improved before surgery, the average result was 66.2 ± 0.5 points, 6 months after surgery 94.1 ± 0.6 points. When studying the QoL score scale before surgery, it was 5.5 ± 1.2 points, after 6 months 1.6±1.5 points, the total I-PSS score before surgery was 32.1± 3.4 points and after 6 months 7.3± 2.9 points. When assessing the indicators of the maximum urination rate before surgery was 15.8 ± 1.2 ml/s, and in the long term after 6 months in patients, the average Qmax was 23.7 ± 1.7 ml/s. Prior to surgical treatment, 84.0% of patients with urethral stricture with scleroatrophic lichen had pain during sexual intercourse, discomfort in the urethra in 64.0% of patients. After buccal urethroplasty after six months, the patient’s quality of life improved, pain during sexual intercourse decreased to 8.0%.Conclusion. Replacement of affected urethral tissues with scleroatrophic lichen with buccal flap helps restore adequate urination and improve patient quality of life.

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Section: Introductionunclassified

Urethral strictures caused by lichen sclerosus: evaluation of patient quality of life after buccal urethroplasty

et al. 2022

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Lichen Sclerosus of the Vulva in Patients With Limited Scleroderma

Татарчук¹,

Проценко

Dunaevskaya

2020

Clin. and prev. med.

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Modern literature information on the etiopathogenetic prevalence of lichen sclerosus has been presented by the authors; clinical manifestations and classification of the disease have been outlined; diagnosis and treatment issues have been discussed in the article. 3 clinical cases of genital lesions in the form of lichen sclerosus in patients with limited scleroderma have been described. In our opinion, lichen sclerosus is one of the forms of limited scleroderma. Purpose. To investigate the conditions for the diagnosis and treatment of genital lesions in the form of lichen sclerosus in patients with limited scleroderma. Methods. The first line of therapy for lichen sclerosus is the use of super-powerful topical glucocorticoids. Clobetasol propionate 0.05% is to be used for 3 months (1 month daily, then every other day for a month, then 2 times a week for a month). After 3 months of treatment, if a positive effect is declared, maintenance therapy is recommended once a week. Topical calcineurin inhibitors are recommended as a second-line therapy. Effective and safe excipients are emollients that moisturize the skin and mucous membranes, prevent transdermal fluid loss, and reduce subclinical inflammation. The possibility of using triamcinolone (1-2 mg) onto pathologically altered tissue in women with lichen sclerosus where there are hyperkeratotic sites resistant to GCS can be considered after exclusion of intraepithelial neoplasia or malignant transformation. The effectiveness of physiotherapeutic methods, such as low-intensity helium-neon laser radiation in the red or infrared range, treatment with sunlight and radiation generated by medical equipment, photodynamic therapy has been described. Results. One of the important measures is the elimination of irritating factors, as well as careful care of the vulva and the treatment of secondary infection. It consists in adherence to a diet (exclusion of spicy, salty, sweet foods, caffeine-containing products, alcohol) and intimate hygiene rules (limitation / exclusion of soap-containing products, deodorants, synthetic underwear, pads, tampons). The underwear should not be very tight. In addition, patients should exclude mechanical irritation of the affected area, including shaving. With extreme manifestation of itching, it is recommended to prescribe desensitizing therapy and sedatives. Conclusions. Clinical cases of practical interest in connection with the clinical manifestations of limited scleroderma on the skin and genitals have been considered. Frequent lesions of the genital organs in the form of a typical clinic of lichen sclerosus in women suffering from limited scleroderma, the similarity of their clinic, histological picture and pathogenesis have been noted. All this gives a reason to consider lichen sclerosus as a manifestation of limited scleroderma.

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Anogenital localization of localized scleroderma in older women: complexity of diagnosis and clinical features

Снарская

Семенчак

2019

Medicinskij alfavit

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According to the criteria of the world health organization, the geriatric population is people who have reached the age of 60 years. Biological aging is accompanied by a progressive decrease in the functional and reserve capabilities of all structural elements of the skin, is a complex process and the result of the influence of both non-modifiable (chronological aging, ethnicity and natural anatomical changes) and modifiable factors (hypoestrogenation, exposure to ultraviolet rays, stress, etc.) Dermatoses occurring with the defeat of the anogenital region in the geriatric group of patients are a big problem not only for diagnosis and treatment, but also significantly worsen the quality of life of patients. Extensive lesions of the anogenital zone are one of the characteristic clinical signs of limited scleroderma, in particular one of its clinical variants — scleroatrophic lichen. (Lichen sclerosis and atroficus). Scleroatrophic lichen (SL) is a chronic autoimmune dermatosis, occurring with a predominant lesion of anogenital tissues, in 85–93 % of cases in women and men.

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Clinical features of genital lichen sclerosus et atrophica in males and females

Cited by 4 publications

References 4 publications

Urethral strictures caused by lichen sclerosus: evaluation of patient quality of life after buccal urethroplasty

Urethral strictures caused by lichen sclerosus: evaluation of patient quality of life after buccal urethroplasty

Lichen Sclerosus of the Vulva in Patients With Limited Scleroderma

Anogenital localization of localized scleroderma in older women: complexity of diagnosis and clinical features

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